Resveratrol Pretreatment Ameliorates TNBS Colitis in Rats

Yıldız, Gülserap; Yildiz, Yuksel; Ulutaş, Pınar Alkım; Yaylali, Aslı; Ural, Mürüvvet

doi:10.2174/1872214809666150806105737

Cited by 50 publications

(29 citation statements)

References 40 publications

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“…In another mouse colitis model using IL-10 −/− mice which develop spontaneous chronic colitis within 18 weeks, resveratrol was able to induce immunosuppressive CD11b + Gr-1 + MDSCs in the colon and suggests an as-yet-unidentified mode of anti-inflammatory action of this plant polyphenol [19]. Similar positive outcomes of resveratrol treatment were demonstrated in various rat colitis and Crohn's disease models including 2,4,6-trinitrobenzene sulfonic acid (TNBS), oxazolone, and peptidoglycan-polysaccharide [20–23]. Furthermore, Samsami-Kor et al performed a pilot study on patients with ulcerative colitis showing that 6 weeks of resveratrol supplementation was able to improve quality of life in patients with active colitis at least partially through inflammation reduction.…”

Section: Introductionmentioning

confidence: 92%

Sex Differences in the Effect of Resveratrol on DSS-Induced Colitis in Mice

Wagnerová

Bábíčková

Lipták

et al. 2017

Gastroenterology Research and Practice

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Resveratrol is a natural polyphenol studied for its possible protective properties in inflammatory bowel diseases. Moreover, it has been shown to interact with estrogen receptors. In the present study, we aimed to investigate possible diverse effects of resveratrol on female and male mice in DSS-induced colitis. Thirty-seven C57BL/6 mice (21 female and 16 male) were divided into three groups for each sex. The first group received pure water (CTRL). The other two groups received 1.5% dextran sulfate sodium (DSS) to induce colitis from which one group was treated with resveratrol (DSS + RSV). Intake of 1.5% DSS caused weight loss in all DSS groups compared to control mice. Weight loss, stool consistency, and discomfort did not show any protective effect of resveratrol in males and showed even adverse effects in females. In females, the activity of myeloperoxidase was lower compared to that in males. However, colon length and spleen weight showed no sex differences, which can indicate the induction of only mild colitis in mice. Resveratrol did not have any effect on TNF-alpha levels. Taken together, these results for the first time propose possible diverse effects of resveratrol in DSS-induced colitis model depending on the sex of the animal. However, this conclusion must be confirmed by further analyses.

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Section: Introductionmentioning

confidence: 92%

Sex Differences in the Effect of Resveratrol on DSS-Induced Colitis in Mice

Wagnerová

Bábíčková

Lipták

et al. 2017

Gastroenterology Research and Practice

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“…In animal models of IBD, RES administration was very effective in reducing mucosal inflammation via inhibition of malondialdehyde and increase of glutathione peroxidase activities, respectively [239][240][241][242][243][244]. Furthermore, in the above models, decrease in neutrophil infiltration and proinflammatory cytokine release and increase in number of Bifidobacteria and Lactobacilli with reduction of intestinal wall fibrosis have been observed [239][240][241][242][243][244].…”

Section: Allergy and Autoimmune Diseasesmentioning

confidence: 90%

Recent Advances on the Anti-Inflammatory and Antioxidant Properties of Red Grape Polyphenols: In Vitro and In Vivo Studies

Magrone

Russo

et al. 2019

Antioxidants

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In this review, special emphasis will be placed on red grape polyphenols for their antioxidant and anti-inflammatory activities. Therefore, their capacity to inhibit major pathways responsible for activation of oxidative systems and expression and release of proinflammatory cytokines and chemokines will be discussed. Furthermore, regulation of immune cells by polyphenols will be illustrated with special reference to the activation of T regulatory cells which support a tolerogenic pathway at intestinal level. Additionally, the effects of red grape polyphenols will be analyzed in obesity, as a low-grade systemic inflammation. Also, possible modifications of inflammatory bowel disease biomarkers and clinical course have been studied upon polyphenol administration, either in animal models or in clinical trials. Moreover, the ability of polyphenols to cross the blood–brain barrier has been exploited to investigate their neuroprotective properties. In cancer, polyphenols seem to exert several beneficial effects, even if conflicting data are reported about their influence on T regulatory cells. Finally, the effects of polyphenols have been evaluated in experimental models of allergy and autoimmune diseases. Conclusively, red grape polyphenols are endowed with a great antioxidant and anti-inflammatory potential but some issues, such as polyphenol bioavailability, activity of metabolites, and interaction with microbiota, deserve deeper studies.

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“…In animal models of IBD, RES administration was very effective in reducing mucosal inflammation, inhibiting malondialdehyde and increasing glutathione peroxidase activity; decreasing neutrophil infiltration and pro-inflammatory cytokine release and augmenting number Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 3 December 2019 doi:10.20944/preprints201912.0030.v1 of bifidobacteria and lactobacilli; diminishing expression of COX-2, PGD2, PGE synthase-1 and lowering TGF-1 and fibrosis of the intestinal wall [235][236][237][238][239][240]. RES has been experimented either in vitro or in vivo in rheumatoid arthritis.…”

Section: Allergy and Autoimmune Diseasesmentioning

confidence: 99%

Recent Advances on the Anti-inflammatory and Anti-oxidant properties of Red Grape Polyphenols: In Vitro and in Vivo Studies

Magrone¹,

Magrone²,

Russo³

et al. 2019

Preprint

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In this review, special emphasis will be placed on red grape polyphenols for their anti-oxidant and anti-inflammatory activities. Therefore, their capacity to inhibit major pathways responsible for activation of oxidative systems and expression and release of pro-inflammatory cytokines and chemokines will be discussed. Furthermore, regulation of immune cells by polyphenols will be illustrated with special reference to the activation of T regulatory cells which support a tolerogenic pathway at intestinal level. Furthermore, the effects of red grape polyphenols will be analyzed in obesity, as a low grade systemic inflammation. Also, possible modifications of inflammatory bowel disease biomarkers and clinical course have been studied upon polyphenol administration, either in animal models or in clinical trials. Moreover, the ability of polyphenols to cross the blood-brain barrier has been exploited to investigate their neuroprotective properties. In cancer, polyphenols seem to exert several beneficial effects, even if conflicting data are reported about their influence on T regulatory cells. Finally, the effects of polyphenols have been evaluated in experimental models of allergy and autoimmune diseases. Conclusively, red grape polyphenols are endowed with a great anti-oxidant and anti-inflammatory potential but some issues, such as polyphenol bioavailability, activity of metabolites and interaction with microbiota, deserve deeper studies.

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Resveratrol Pretreatment Ameliorates TNBS Colitis in Rats

Cited by 50 publications

References 40 publications

Sex Differences in the Effect of Resveratrol on DSS-Induced Colitis in Mice

Sex Differences in the Effect of Resveratrol on DSS-Induced Colitis in Mice

Recent Advances on the Anti-Inflammatory and Antioxidant Properties of Red Grape Polyphenols: In Vitro and In Vivo Studies

Recent Advances on the Anti-inflammatory and Anti-oxidant properties of Red Grape Polyphenols: In Vitro and in Vivo Studies

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