A B S T R A C TA computational study is conducted to determine the influence of microstructure attributes and properties on driving forces for fatigue crack formation and microstructurally small crack growth in a polycrystalline Ni-base superalloy, IN100, a turbine disk alloy. A principal objective is to obtain quantitative estimates of the effect of variability of microstructure features on scatter in fatigue life or fatigue strength for a given life. Understanding is sought regarding sensitivity of driving forces to various microstructure attributes that may guide selection of the process route to tailor microstructure to achieve fatigue resistance. A microstructure-sensitive crystal plasticity model is used to explicitly model individual grains and polycrystals, which is then used to explore effects of: (a) grain size distribution and (b) secondary and tertiary coherent γ precipitate size distributions and volume fractions on the cyclic inelastic strain distribution. Multiple statistical volume elements (SVEs) are subjected to random periodic boundary conditions to build up statistically significant measures of distributions of cyclic microplasticity. Multiaxial fatigue criteria with critical plane approaches are used to estimate the crack initiation life. Methods are developed for assessing crack formation and microstructurally small crack growth as a function of microstructure attributes. = Plastic rate of deformation tensors in intermediate and current configurations, respectively d 2 , d 3 = Secondary and tertiary γ precipitate sizes, respectively d gr = Mean grain size F, F e , F p = Total, elastic and plastic deformation gradient tensors, respectively FIP = Fatigue indicator parameter (e.g. P FS , P mps , P cyc ) FIP ,av = Average value of the FIP over all elements in the grain (e.g. P FS,av ) FIP ,max = Maximum value of the FIP over all elements in the grain (e.g. P FS,max ) f p2 , f p3 = Secondary and tertiary γ precipitate volume fractions, respectivelŷ L p = Plastic velocity gradient tensor in the intermediate configuration M = Taylor factor (3.06 for fcc polycrystals with random texture) max FIP ,max = Maximum value of the FIP ,max over all grains in the SVE m α o = Unit normal vector in the reference configuration on slip system α N f = Number of cycles for specimen failure N inc = Crack incubation life N I = Crack initiation life, defined as the number of cycles for a crack to incubate and grow to 3d gr