We study the fundamental bounds on precision measurements of parameters contained in a timedependent nonlinear optomechanical Hamiltonian, which includes the nonlinear light-matter coupling, a mechanical displacement term, and a single-mode mechanical squeezing term. By using a recently developed method to solve the dynamics of this system, we derive a general expression for the quantum Fisher information and demonstrate its applicability through three concrete examples: estimation of the strength of a nonlinear light-matter coupling, the strength of a time-modulated mechanical displacement, and a single-mode mechanical squeezing parameter, all of which are modulated at resonance. Our results can be used to compute the sensitivity of a nonlinear optomechanical system to a number of external and internal effects, such as forces acting on the system or modulations of the light-matter coupling.arXiv:1910.04485v1 [quant-ph]