Probing chiral amino acids at sub-picomolar level based on bovine serum albumin enantioselective films coupled with silver-enhanced gold nanoparticles

Yin, Xiuli; Shi, Mianhong; Li, Wei; Zhang, Lei; Kong, Jilie

doi:10.1016/j.talanta.2005.12.060

Cited by 61 publications

(35 citation statements)

References 22 publications

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“…The signal was monitored by differential potential voltammetry with a glassy carbon electrode modified with bovine serum albumin, which is a chiral modifier, and amplified by silver atoms anchored on the AuNPs. [118] Similarly, Rotello et al have clearly demonstrated by calorimetric studies that NPs bearing enantiomeric and diastereoisomeric end groups have distinctly different binding affinities towards protein targets. [82] They further demonstrated that trimethylammonium-funtionalized AuNPs protected with mixed monolayers can stabilize peptides in water through favorable interactions on templation of the NPs to the peptide surface.…”

Section: Chiral Discriminationmentioning

confidence: 93%

Chiral Gold Nanoparticles

2009

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Monolayer-protected gold nanoparticles have many appealing physical and chemical properties such as quantum size effects, surface plasmon resonance, and catalytic activity. These hybrid organic-inorganic nanomaterials have promising potential applications as building blocks for nanotechnology, as catalysts, and as sensors. Recently, the chirality of these materials has attracted attention, and application to chiral technologies is an interesting perspective. This minireview deals with the preparation of chiral gold nanoparticles and their chiroptical properties. On the basis of the latter, together with predictions from quantum chemical calculations, we discuss different models that were put forward in the past to rationalize the observed optical activity in metal-based electronic transitions. We furthermore critically discuss these models in view of recent results on the structure determination of some gold clusters as well as ligand-exchange experiments examined by circular dichroism spectroscopy. It is also demonstrated that vibrational circular dichroism can be used to determine the structure of a chiral adsorbate and the way it interacts with the metal. Finally, possible applications of these new chiral materials are discussed.

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Section: Chiral Discriminationmentioning

confidence: 93%

Chiral Gold Nanoparticles

2009

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“…A key step in sensing chiral molecules is to build a chiral surface that can identify the minute differences between the enantiomers [9][10][11][12][13]. A variety of methods such as coating, covalent bonding and self-assembly have been applied to prepare the chiral surface or directly utilize gold chiral surfaces [14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Recognition of Chiral Molecules with Poly(4‐bromoaniline) Modified Gold Electrode

Wang

2013

Electroanalysis

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A poly(4-bromoaniline) (PBA) film is electrochemically synthesized on a gold electrode for the recognition of amino acids enantiomers. Scanning electron microscopy measurements show that the porous PBA films are made up of nano-ribbons. At the PBA modified Au electrode differential pulse voltammograms of l-and d-glutamic acids not only have very different current densities, but also produce different waveforms, providing an intuitive way to differentiate the two chiral molecules. Similar results are obtained in analyzing l-and d-aspartic acids. Control experiments suggest that the observed sensing behavior arises from synergistic interactions between Au and the PBA film, where polymerization at the meta-position creates a steric structure needed for differentiating chiral molecules.

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“…Therefore, developing effective methods for chiral analysis is an attractive work and a research focus. There are many techniques developed for chiral analysis, including high-performance liquid chromatography [5][6][7], capillary electrophoresis [8,9], quartz crystal microbalance [10,11], fluorescence detection [12,13], nuclear magnetic resonance protocols [14], and electrochemical methods [15,16]. Among these approaches, electrochemical methods, an important and powerful analytical tool, have attracted considerable attention [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

A new chiral electrochemical sensor for the enantioselective recognition of penicillamine enantiomers

Qiao

Zhou

Han

et al. 2012

J Solid State Electrochem

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A new chiral electrochemical sensor has been successfully prepared through chemical linking L-methotrexate (L-Mtx) onto the gold electrode surface. Cyclic voltammetry and electrochemical impedance spectroscopy were used to investigate the enantioselective interaction between L-Mtx and Pen enantiomers. The results showed that the L-Mtx-modified gold electrode can selectively recognize penicillamine (Pen) enantiomers using Zn(II) as central ion, and larger response signal was observed from D-Pen owing to the selective formation of Zn complexes. The interaction time between the modified electrode and Pen enantiomers containing Zn(II) was considered. And the electrochemical response of the modified electrode to a series of different concentration of Pen in the presence of Zn(II) was also monitored. In addition, the enantiomeric composition of D-and L-Pen enantiomer mixtures was monitored by measuring the current responses of the sample.

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Probing chiral amino acids at sub-picomolar level based on bovine serum albumin enantioselective films coupled with silver-enhanced gold nanoparticles

Cited by 61 publications

References 22 publications

Chiral Gold Nanoparticles

Chiral Gold Nanoparticles

Electrochemical Recognition of Chiral Molecules with Poly(4‐bromoaniline) Modified Gold Electrode

A new chiral electrochemical sensor for the enantioselective recognition of penicillamine enantiomers

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