Probing mesoporous Zr-MOF as drug delivery system for carboxylate functionalized molecules

Pander, Marzena; Żelichowska, Anna; Bury, Wojciech

doi:10.1016/j.poly.2018.09.006

Cited by 37 publications

(23 citation statements)

References 24 publications

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“…294 The natural crystalline porosity of MOFs has attracted the attention for the development of new and efficient drug delivery systems. 296 Drug delivery systems are devices that enable a therapeutic substance to selectively reach its site of action without reaching the non-target cell, organs, or tissues. Such devices should accomplish a controlled and sustained release of the medicine, to minimize side effects and ensure the efficacy of the pharmaceutical upon reaching the desired target.…”

Section: Bio-medical Applicationsmentioning

confidence: 99%

Pyrene-based metal organic frameworks: from synthesis to applications

et al. 2021

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Section: Bio-medical Applicationsmentioning

confidence: 99%

Pyrene-based metal organic frameworks: from synthesis to applications

et al. 2021

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“…It should be mentioned that the diameter of the hollow space is approximately 4 nm and has been proven to load small-molecule medicines, such as doxorubicin, to deliver drugs. 41,42 To confirm that the FA molecules were conjugated with Hf 6, fHMNM, FA and the supernatant of the last wash from the reaction between FA and Hf-Mn-NMOF were subjected to UV-Vis analysis. As shown in Figure 2D, fHMNM shows a combined absorption spectrum with NMOF at 420 nm and 490 nm and with FA at 280 nm and 350 nm.…”

Section: Characterization Of Fa-hf-mn-nmofmentioning

confidence: 99%

<p>Multifunctional Hf/Mn-TCPP Metal-Organic Framework Nanoparticles for Triple-Modality Imaging-Guided PTT/RT Synergistic Cancer Therapy</p>

Bao¹,

Zu²,

Wang³

et al. 2020

IJN

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Background: Recent studies have validated and confirmed the great potential of nanoscale metal-organic framework (NMOF) in the biomedical field, especially in improving the efficiency of cancer diagnosis and therapy. However, most previous studies only utilized either the metal cluster or the organic ligand of the NMOF for cancer treatments and merely reported limited theranostic functions, which may not be optimized. As a highly designable and easily functionalized material, prospective rational design offers a powerful way to extract the maximum benefit from NMOF for cancer theranostic applications. Materials and Methods: A NMOF based on hafnium (Hf) cluster and Mn(III)-porphyrin ligand was rational designed and synthesized as a high-performance multifunctional theranostic agent. The folic acid (FA) was modified on the NMOF surface to enhance the cancer targeting efficacy. The proposed "all-in-one" FA-Hf-Mn-NMOF (fHMNM) was characterized and identified using various analytical techniques. Then, in vitro and in vivo studies were performed to further explore the effects of fHMNM both as the magnetic resonance imaging (MRI)/computed tomography (CT)/photoacoustic imaging (PAI) contrast agent and as the photothermal therapy (PTT)/radiotherapy (RT) agent. Results: A tumour targeting multifunctional fHMNM was successfully synthesized with high performance for MRI/CT/PAI enhancements and image-guided PTT/RT synergistic therapy properties. Compared with the current clinical CT and MR contrast agents, the X-ray attenuation and T 1 relaxation rate of this integrated nanosystem increased 1.7-fold and 3-5-fold, respectively. More importantly, the catalase-like Mn(III)-porphyrin ligand can decompose H 2 O 2 into O 2 in tumour microenvironments to improve the synergistic treatment efficiency of PTT and RT. Significant tumour growth inhibition was achieved in mouse cancer models without obvious damage to the other organs. Conclusion: This work highlights the potential of fHMNM as an easily designable material for biomedical applications, could be an effective tool for in vivo detection and subsequent treatment of tumour.

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“…The terminal hydroxyl groups in Zr 6 nodes can facilitate the loading of carboxyl-containing drugs. 26 However, the effect of functional groups with different properties and sizes on the delivery behaviour of MOFs has not been systematically studied.…”

Section: Introductionmentioning

confidence: 99%