Abstract:26Glutamate delta (GluD) receptors belong to the ionotropic glutamate receptor family, 27 yet whether they actually form functional and physiologically-relevant ion channels in 28 neurons remains a debated question. Here we used a chemo-genetic approach to 29 engineer specific and photo-reversible pharmacology in the orphan GluD2 receptor. 30We incorporated a cysteine mutation in the cavity located above the putative ion 31 channel pore, for site-specific conjugation with a photoswitchable ligand. We first 32 … Show more
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