Probing the structural features of a plasma-treated chitosan-acrylic acid hydrogel

Taaca, Kathrina Lois M.; Leon, Mark Jeffry D. De; Thumanu, Kanjana; Nakajima, Hideki; Chanlek, Narong; Prieto, Eloise I.; Vasquez, Magdaleno R.

doi:10.1016/j.colsurfa.2021.128233

Cited by 11 publications

(4 citation statements)

References 47 publications

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“…With plasma treatment, another linkage may have been established through the C-O bridge. A multivariate analysis approach further confirmed that the change observed along the C=O bond and C-O linkage of the hydrogel is significant at higher chitosan concentration (2.5 wt%) than lower chitosan concentration [153]. The viability of APP treatment as a precrosslinking step was also observed with a poly(ethylene oxide) (PEO) model.…”

Section: Plasma-induced Crosslinkingmentioning

confidence: 64%

Current Trends in Biomedical Hydrogels: From Traditional Crosslinking to Plasma-Assisted Synthesis

2022

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The use of materials to restore or replace the functions of damaged body parts has been proven historically. Any material can be considered as a biomaterial as long as it performs its biological function and does not cause adverse effects to the host. With the increasing demands for biofunctionality, biomaterials nowadays may not only encompass inertness but also specialized utility towards the target biological application. A hydrogel is a biomaterial with a 3D network made of hydrophilic polymers. It is regarded as one of the earliest biomaterials developed for human use. The preparation of hydrogel is often attributed to the polymerization of monomers or crosslinking of hydrophilic polymers to achieve the desired ability to hold large amounts of aqueous solvents and biological fluids. The generation of hydrogels, however, is shifting towards developing hydrogels through the aid of enabling technologies. This review provides the evolution of hydrogels and the different approaches considered for hydrogel preparation. Further, this review presents the plasma process as an enabling technology for tailoring hydrogel properties. The mechanism of plasma-assisted treatment during hydrogel synthesis and the current use of the plasma-treated hydrogels are also discussed.

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Section: Plasma-induced Crosslinkingmentioning

confidence: 64%

Current Trends in Biomedical Hydrogels: From Traditional Crosslinking to Plasma-Assisted Synthesis

2022

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“…Hydrophilicity of the hydrogel surface is improved due to the increases in hydrophilic chemical groups (-COOH and -NH 2 ) by the treatment [ 157 ]. This plasma treatment is used not only for surface functionalization but also facilitating the crosslinking of chitosan and acrylic acid [ 146 ]. Besides the acrylic acid that promoted protonated amine formation, there is an increase in the protonated amines by using N 2 as a working gas, especially at high chitosan concentrations [ 146 ].…”

Section: Gelation Techniques Of Chitosan-based Hydrogelsmentioning

confidence: 99%

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Taokaew

Kaewkong

Kriangkrai

2023

Gels

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Chitosan is a promising naturally derived polysaccharide to be used in hydrogel forms for pharmaceutical and biomedical applications. The multifunctional chitosan-based hydrogels have attractive properties such as the ability to encapsulate, carry, and release the drug, biocompatibility, biodegradability, and non-immunogenicity. In this review, the advanced functions of the chitosan-based hydrogels are summarized, with emphasis on fabrications and resultant properties reported in literature from the recent decade. The recent progress in the applications of drug delivery, tissue engineering, disease treatments, and biosensors are reviewed. Current challenges and future development direction of the chitosan-based hydrogels for pharmaceutical and biomedical applications are prospected.

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“…The treatment by plasma jet also establishes another connection via C-O bridges, for example, when a high concentration of chitosan (2.5 wt%) is treated by plasma, the changes of C=O and C-O bonds are more pronounced than those at low chitosan concentrations, thereby establishing partial covalent crosslinks and the aggregation of micelles in the hydrogel network, leading to an increase in molar mass and viscosity. Ultimately, plasma treatment doubled the elasticity of the hydrogel [46,47].…”

Section: Fabrication Mechanism Of Functional Pahmentioning

confidence: 99%

Plasma-activated hydrogel: fabrication, functionalization, and effective biological model

Lan

Nie

et al. 2023

Plasma Sci. Technol.

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Hydrogels are biomaterials with 3D networks of hydrophilic polymers. The generation of hydrogels is turning to the development of hydrogels with the help of enabling technologies. Plasma can tailor the hydrogels’ properties through simultaneous physical and chemical actions, resulting in an emerging technology of plasma-activated hydrogels (PAH). PAH can be divided into functional PAH and biological tissue model PAH. This review systematically introduces the plasma sources, plasma etching polymer surface, and plasma cross-linking involved in the fabrication of PAH. The “diffusion-drift-reaction model” is used to study the microscopic physicochemical interaction between plasma and biological tissue PAH models. Finally, the main achievements of PAH, including wound treatment, sterilization, 3D tumor model, etc., and their development trends are discussed.

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Probing the structural features of a plasma-treated chitosan-acrylic acid hydrogel

Cited by 11 publications

References 47 publications

Current Trends in Biomedical Hydrogels: From Traditional Crosslinking to Plasma-Assisted Synthesis

Current Trends in Biomedical Hydrogels: From Traditional Crosslinking to Plasma-Assisted Synthesis

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Plasma-activated hydrogel: fabrication, functionalization, and effective biological model

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