Probiotic Bacteria as Live Oral Vaccines Lactobacillus as the Versatile Delivery Vehicle

Boersma, W.J.A.; Shaw, M.; Claassen, Eric

doi:10.1007/978-94-017-2768-6_10

Cited by 8 publications

(5 citation statements)

References 68 publications

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“…Hence, in order to efficiently prevent respiratory infections, the activation of the mucosal immune system is essential. 43 Since numerous studies have demonstrated that the nasal administration of an antigen is the most efficient route to elicit optimal protective immunity in both the mucosal and the systemic immune compartments, nasal immunization is commonly used to induce immunity along the respiratory tract. 44 The nasopharyngeal associated lymphoid tissue (NALT) contains all the lymphoid cells required for the induction and regulation of the mucosal immune response to antigens delivered into the nasal cavity.…”

Section: Lactococcus Lactis Nasally Administered As An Adjuvant and Dmentioning

confidence: 99%

Lactococcus lactisas an adjuvant and delivery vehicle of antigens against pneumococcal respiratory infections

et al. 2010

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Section: Lactococcus Lactis Nasally Administered As An Adjuvant and Dmentioning

confidence: 99%

Lactococcus lactisas an adjuvant and delivery vehicle of antigens against pneumococcal respiratory infections

et al. 2010

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“…These microorganisms are called probiotic (Fuller, 1989) and their beneficial effects, within others, include enhancement of the non-specific and specific immune responses, control of intestinal infections, and anticarcinogenic activity (De Simone et al, 1993, LinkAmster et al, 1994Majamaa et al, 1995). The fact that they are non-pathogenic and safe for human consumption makes LAB attractive as mucosal adjuvant or live vectors for oral vaccines (Mercenier et al, 1995;Boersma et al, 2000). Since the bacterial properties required for the different applications are clearly distinct, strain selection is very important for a more rational use of these microorganisms.…”

Section: Introductionmentioning

confidence: 99%

Interaction of lactic acid bacteria with the gut immune system

et al. 2002

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Health claims of lactic acid bacteria (LAB) used in functional foods and pharmaceutical preparations are based on the capacity of these microorganisms to stimulate the host immune system. In this study, the antigenic effect of LAB (Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus delbrueckii ssp. bulgaricus and Streptococcus thermophilus) on the gut immune system of BALB=c mice was evaluated. A dose-dependent increase of the Bcl2 protein was observed with all LAB assayed. Furthermore, the analysis of cytokine-producing cells in the lamina propria of gut showed that TNFa and INFg values, determined in macrophages cultured from Peyer patches, were enhanced for all the LAB assayed. An important increase of interleukins IL-10 and IL-4 was observed mainly in mice fed with Lactobacillus delbrueckii ssp. bulgaricus or Lactobacillus casei, while a significant induction of IL-2 and IL-12 was only observed with L. acidophilus (P < 0.01). These effects were dose dependent. The role of produced cytokines in the balance Th1=Th2 was determined by a systemic antibody response against parenterally injected ovoalbumin. L. casei, L. delbrueckii ssp. bulgaricus and L. acidophilus enhanced the IgG1 response favouring Th2 balance, while L. acidophilus also increased the IgG2a response inducing Th1 balance. S. thermophilus did not influence the balance Th1=Th2. Our studies showed that lactic acid bacteria induce distinct mucosal cytokine profiles showing different adjuvant capacity among them. Thus, selection of probiotic strain with immunological properties must be well defined to influence cytokine expression that favour the claimed immune response.

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“…or s.c.) mainly lead to systemic immunization. However, as most pathogens enter the body via the mucosa of the gastrointestinal, respiratory or urogenital tracts, protection of individuals against invasion of infectious agents via the mucosa should preferably include activation of the mucosal immune system (11).…”

mentioning

confidence: 99%

Nasal administration of Lactococcus lactis improves local and systemic immune responses against Streptococcus pneumoniae

Medina

Villena

Salva

et al. 2008

Microbiology and Immunology

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Lactococcus lactis NZ9000 is a non-pathogenic non-invasive bacterium extensively used for the delivery of antigens and cytokines at the mucosal level. However, there are no reports concerning the per se immunomodulatory capacity of this strain. The aim of the present study was to investigate the intrinsic immunostimulating properties of the nasal administration of L. lactis NZ9000 in a pneumococcal infection model. Mice were preventively treated with L. lactis Key words adjuvant, Lactococcus lactis, nasal administration, pneumococcal infection.Bacterial respiratory diseases remain a major cause of morbidity and mortality in both developed and developing communities. In Argentina, Streptococcus pneumoniae is one of the most important respiratory pathogens (1). This bacterium can migrate to mucosal areas that are normally sterile and lead to a variety of mucosal infections such as otitis media or pneumonia. In addition, pneumococci can induce invasive cases of septicemia and meningitis. The high morbidity associated with this microorganism remains a leading cause of mortality in the young and the elderly (2). The deaths caused by S. pneumoniae are concentrated in developing countries, where the rates are

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Probiotic Bacteria as Live Oral Vaccines Lactobacillus as the Versatile Delivery Vehicle

Cited by 8 publications

References 68 publications

Lactococcus lactisas an adjuvant and delivery vehicle of antigens against pneumococcal respiratory infections

Lactococcus lactisas an adjuvant and delivery vehicle of antigens against pneumococcal respiratory infections

Interaction of lactic acid bacteria with the gut immune system

Nasal administration of Lactococcus lactis improves local and systemic immune responses against Streptococcus pneumoniae

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