Probiotic bacteria down‐regulate the milk‐induced inflammatory response in milk‐hypersensitive subjects but have an immunostimulatory effect in healthy subjects

Pelto, Leea; Isolauri, Erika; Lilius, Esa‐Matti; Nuutila, Jari; Salminen, Seppo

doi:10.1046/j.1365-2222.1998.00449.x

Cited by 238 publications

(130 citation statements)

References 35 publications

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“…This shows that the probiotic diet increases respiratory burst activity and complement activity in common carp. It has been shown that certain probiotic bacteria and triherbal extracts are able to stimulate phagocytic activity (Arunachalam et al 2000, Schiffrin et al 1997, Harikrishnan et al 2009) as well as complement receptor expression (Pelto et al 1998). Respiratory burst activity correlates well with phagocytosis of bacteria in fish (Hardie et al 1996, Neumann et al 2001 as well as in humans (Loimaranta et al 1999).…”

Section: Discussionmentioning

confidence: 99%

Potential use of probiotic- and triherbal extract-enriched diets to control Aeromonas hydrophila infection in carp

Harikrishnan

Balasundaram²,

Heo

2010

Dis. Aquat. Org.

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This study reports the effect of probiotic-and triherbal extract-enriched diet on Cyprinus carpio (52 ± 2 g, n = 250) inoculated intramuscularly (50 µl) with Aeromonas hydrophila (1.8 × 10 6 CFU ml -1). On Day 6 post-infection, the fish were divided into 4 groups and fed with the basal diet (IU) or with diets supplemented with triherbal extract (H), Sporolac (S) or Lactobacillus (L). A fifth group of non-infected fish fed with the basal diet was used as a control. Haematology and immunology parameters were measured in Weeks 1, 2 and 4. In the H, S, and L groups, white blood cell levels were significantly increased (p < 0.05) throughout the experimental period. In the H and S groups, red blood cell and haemoglobin levels decreased significantly (p < 0.05) in Weeks 1, 2 and 4. In all the diet groups, the haematocrit and mean corpuscular volume did not differ significantly (p > 0.05) in Week 1, and these values remained near those of the control in Week 2. The S and L groups did not exhibit significant changes (p > 0.05) in glucose, and cholesterol levels in Weeks 2 and 4 compared to controls, and the L group also showed no change in total protein. Respiratory burst activity was significantly increased in Weeks 1 to 4 in the H, S and L groups. Serum-mediated killing of Escherichia coli was significantly increased in the L group in Weeks 1 to 4. Mortalities after A. hydrophila challenge were higher in the IU (85%) and H (50%) groups than in the S (45%) and L (35%) groups. Our results show that formulated probiotic-enriched diets can speed up the recovery of ulcerative dermatitis induced by A. hydrophila in carp. KEY WORDS: Aeromonas hydrophila · Cyprinus carpio · Haematology · Triherbal extract · ProbioticsResale or republication not permitted without written consent of the publisher

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Section: Discussionmentioning

confidence: 99%

Potential use of probiotic- and triherbal extract-enriched diets to control Aeromonas hydrophila infection in carp

Harikrishnan

Balasundaram²,

Heo

2010

Dis. Aquat. Org.

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“…In this process, it needs to be taken into account that the response to probiotic supplementation depends on the immunological status of the host, as demonstrated by in vitro 98,199 and in vivo experiments. 168,200 What ultimately counts in the search for functional foods to modulate the immune response is that well-tolerated and effective nutrients are needed, and probiotics are currently among the best candidates to play this critical role in future epidemics of metabolic and infl ammatory conditions.…”

Section: Final Comments and Thoughtsmentioning

confidence: 99%

Probiotics and immunity

et al. 2009

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Probiotics are defi ned as live microorganisms that, when administered in adequate amounts, confer a health benefi t on the host, including the gastrointestinal tract. While this benefi cial effect was originally thought to stem from improvements in the intestinal microbial balance, there is now substantial evidence that probiotics can also provide benefi ts by modulating immune functions. In animal models, probiotic supplementation is able to provide protection from spontaneous and chemically induced colitis by downregulating infl ammatory cytokines or inducing regulatory mechanisms in a strain-specifi c manner. In animal models of allergen sensitization and murine models of asthma and allergic rhinitis, orally administered probiotics can straindependently decrease allergen-specifi c IgE production, in part by modulating systemic cytokine production. Certain probiotics have been shown to decrease airway hyperresponsiveness and infl ammation by inducing regulatory mechanisms. Promising results have been obtained with probiotics in the treatment of human infl ammatory diseases of the intestine and in the prevention and treatment of atopic eczema in neonates and infants. However, the fi ndings are too variable to allow fi rm conclusions as to the effectiveness of specifi c probiotics in these conditions.

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“…19 In addition, it has been suggested that Lactobacillus exerts an anti-inflammatory effect in milk-hypersensitive children as a result of downregulation of the immunoinflammatory response. 20 The second aim of this pilot study was to test the hypothesis that the administration of probiotics reduces intestinal inflammation in CF.…”

Section: Introductionmentioning

confidence: 99%

Intestinal inflammation is a frequent feature of cystic fibrosis and is reduced by probiotic administration

Bruzzese

Raia

Gaudiello

et al. 2004

Aliment Pharmacol Ther

166

124

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Summary Aims : To assess the incidence of intestinal inflammation in children with cystic fibrosis and to investigate whether probiotics decrease it. Study design : In this two‐phase, controlled, prospective study, faecal calprotectin was measured by enzyme‐linked immunosorbent assay in 30 children with cystic fibrosis, 30 healthy controls and 15 children with active inflammatory bowel disease. Ten children with cystic fibrosis received Lactobacillus GG, and faecal calprotectin was re‐measured 4 weeks later. Rectal nitric oxide production was measured with the rectal dialysis bag technique in 20 children with cystic fibrosis, 20 healthy controls and 15 children with inflammatory bowel disease. Five children with cystic fibrosis received Lactobacillus GG and nitric oxide was re‐measured 4 weeks later. Results : Mean faecal calprotectin was significantly higher in the two groups of patients than in controls. Abnormal values were detected in 27 of 30 cystic fibrosis and in 15 of 15 inflammatory bowel disease children. Also mean nitric oxide production was increased in both group of patients, and abnormal values were detected in 19 of 20 cystic fibrosis and in 15 of 15 inflammatory bowel disease children. Calprotectin and nitric oxide concentrations were reduced after probiotics administration. Conclusions : Intestinal inflammation is a major feature of cystic fibrosis and is reduced by probiotics. The latter finding suggests that intestinal microflora play a major role in intestinal inflammation in cystic fibrosis children.

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Probiotic bacteria down‐regulate the milk‐induced inflammatory response in milk‐hypersensitive subjects but have an immunostimulatory effect in healthy subjects

Abstract: Probiotic bacteria appear to modulate the nonspecific immune response differently in healthy and hypersensitive subjects. This is seen as an immunostimulatory effect in healthy subjects, and as a down-regulation of immunoinflammatory response in milk-hypersensitive subjects.

Cited by 238 publications

References 35 publications

Potential use of probiotic- and triherbal extract-enriched diets to control Aeromonas hydrophila infection in carp

Potential use of probiotic- and triherbal extract-enriched diets to control Aeromonas hydrophila infection in carp

Probiotics and immunity

Intestinal inflammation is a frequent feature of cystic fibrosis and is reduced by probiotic administration

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