Probiotic characteristics of Lactobacillus plantarum AR113 and its molecular mechanism of antioxidant

Lin, Xiangna; Xia, Yongjun; Yang, Yijin; Wang, Guangqiang; Zhou, Wei; Ai, Lianzhong

doi:10.1016/j.lwt.2020.109278

Cited by 37 publications

(28 citation statements)

References 39 publications

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“…Therefore, Lactobacillus play an important role in nutritional status, physiological functions, immune responses, tumorigenesis, and anti-aging processes (33,47,48). The L. plantarum bacterium has good antioxidant capacity (49). In this study, LP-HFY01 was selected from fermented yak yogurt in the early laboratory stage, and it had good gastrointestinal tolerance and antioxidant properties in vitro.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Effect of Soymilk Fermented by Lactobacillus plantarum HFY01 on D-Galactose-Induced Premature Aging Mouse Model

Fan

et al. 2021

Front. Nutr.

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The antioxidant effect of soymilk fermented by Lactobacillus plantarum HFY01 (screened from yak yogurt) was investigated on mice with premature aging induced by D-galactose. In vitro antioxidant results showed that L. plantarum HFY01-fermented soymilk (LP-HFY01-DR) had better ability to scavenge the free radicals 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2′-azino-bis (3-ethylbenzthiazoline-6-sulphonic acid) diammonium salt (ABTS) than unfermented soymilk and Lactobacillus bulgaricus-fermented soymilk. Histopathological observation showed that LP-HFY01-DR could protect the skin, spleen and liver, reduce oxidative damage and inflammation. Biochemical results showed that LP-HFY01-DR could effectively upregulate glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) levels and decrease malondialdehyde (MDA) content in the liver, brain, and serum. Real-time quantitative reverse transcription polymerase chain reaction further showed that LP-HFY01-DR could promote the relative expression levels of the genes encoding for cuprozinc superoxide dismutase (Cu/Zn-SOD, SOD1), manganese superoxide dismutase (Mn-SOD, SOD2), CAT, GSH, and GSH-Px in the liver, spleen, and skin. High-performance liquid chromatography results revealed daidzin, glycitin, genistin, daidzein, glycitein, and genistein in LP-HFY01-DR. In conclusion, LP-HFY01-DR could improve the antioxidant capacity in mice with premature aging induced by D-galactose.

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Section: Discussionmentioning

confidence: 99%

Antioxidant Effect of Soymilk Fermented by Lactobacillus plantarum HFY01 on D-Galactose-Induced Premature Aging Mouse Model

Fan

et al. 2021

Front. Nutr.

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“…Despite the inability to synthesize GSH, lactobacilli possess enzymes of glutathione metabolism: glutathione peroxidase reduces hydrogen peroxide with the participation of glutathione, glutathione reductase restores the disulfide bond of oxidized glutathione, and glutathione transferase performs glutathione attack on cellular toxic compounds, along with detoxification and xenobiotic degradation [122]. Upon H 2 O 2 -induced OS, the transcriptional activity of glutathione reductase gene increased by more than six times in L. plantarum, and the transcription of glutathione peroxidase also increased [123]. Killisaar et al were the first to report that L. fermentum ME-3 possesses a fully functional GSH system comprising both a GSH peroxidase and a GSH reductase [124].…”

Section: Non-enzymatic Antioxidantsmentioning

confidence: 99%

Biomarkers and Utility of the Antioxidant Potential of Probiotic Lactobacilli and Bifidobacteria as Representatives of the Human Gut Microbiota

et al. 2021

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Lactobacilli and bifidobacteria are an important part of human gut microbiota. Among numerous benefits, their antioxidant properties are attracting more and more attention. Multiple in vivo and in vitro studies have demonstrated that lactobacilli and bifidobacteria, along with their cellular components, possess excellent antioxidant capacity, which provides a certain degree of protection to the human body against diseases associated with oxidative stress. Recently, lactobacilli and bifidobacteria have begun to be considered as a new source of natural antioxidants. This review summarizes the current state of research on various antioxidant properties of lactobacilli and bifidobacteria. Special emphasis is given to the mechanisms of antioxidant activity of these bacteria in the human gut microbiota, which involve bacterial cell components and metabolites. This review is also dedicated to the genes involved in the antioxidant properties of lactobacilli and bifidobacteria strains as indicators of their antioxidant potential in human gut microbiota. Identification of the antioxidant biomarkers of the gut microbiota is of great importance both for creating diagnostic systems for assessing oxidative stress and for choosing strategies aimed at restoring the normal functioning of the microbiota and, through it, restoring human health. In this review, the practical application of probiotic strains with proven antioxidant properties to prevent oxidative stress is also considered.

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“…L. plantarum is a facultative hetero-fermentative LAB, which usually ferments carbohydrates through the phosphoketolase pathway [ 18 ]. Different strains of L. plantarum have shown strong acid resistance and bile resistance [ 19 ] and can be found in a variety of environmental niches such as dairy, vegetables, and mammal gastrointestinal tracts, as well as being used in human food, aquaculture, and livestock feed as probiotics [ 20 , 21 , 22 ]. A previous study also indicates that L. plantarum has a beneficial effect on pigs [ 23 , 24 , 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Dietary Probiotic (Lactobacillus plantarum BG0001) Supplementation on the Growth Performance, Nutrient Digestibility, Blood Profile, Fecal Gas Emission, and Fecal Microbiota in Weaning Pigs

Wang

Kim

2021

Animals

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A total of 180, 4-week-old crossbred weaning piglets ((Yorkshire × Landrace) × Duroc; 6.67 ± 1.40 kg) were used in a 42 day experiment to evaluate the effect of dietary probiotics (Lactobacillus plantarum BG0001) on growth performance, nutrient digestibility, blood profile, fecal microbiota, and noxious gas emission. All pigs were randomly allotted to one of four treatment diets in a completely randomized block design. Each treatment had nine replicates with five pigs/pen (mixed sex) Designated dietary treatments were as: (1) basal diet (NC), (2) NC + 0.2% antibiotics (chlortetracycline) (PC), (3) NC + 0.1% L. plantarum BG0001 (Lactobacillus plantarum BG0001) (NC1), (4) NC + 0.2% L. plantarum BG0001 (NC2). On d 42, BW and G:F were lower (p < 0.05) in pigs fed NC diet compared with PC diet and probiotic diets. Throughout this experiment, the average daily gain increased (p < 0.05) in pigs when fed with PC and probiotic diets than the NC diet. The average daily feed intake was higher (p < 0.05) in pigs fed PC diet during day 0–7 and 22–42, and probiotic diets during day 0–7 compared with NC diet, respectively. The Lactobacillus count was increased and Escherichia coli count was decreased (p < 0.05) in the fecal microbiota of pigs fed probiotic diets, and E. coli were decreased (p < 0.05) when fed a PC diet compared with the NC diet on day 21. Moreover, the apparent total tract nutrient digestibility, blood profile, and the concentration of noxious gas emission had no negative effects by the probiotic treatments. In conclusion, dietary supplementation with L. plantarum BG0001 significantly improved the growth performance, increased fecal Lactobacillus, and decreased E. coli counts in weaning pigs.

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Probiotic characteristics of Lactobacillus plantarum AR113 and its molecular mechanism of antioxidant

Cited by 37 publications

References 39 publications

Antioxidant Effect of Soymilk Fermented by Lactobacillus plantarum HFY01 on D-Galactose-Induced Premature Aging Mouse Model

Antioxidant Effect of Soymilk Fermented by Lactobacillus plantarum HFY01 on D-Galactose-Induced Premature Aging Mouse Model

Biomarkers and Utility of the Antioxidant Potential of Probiotic Lactobacilli and Bifidobacteria as Representatives of the Human Gut Microbiota

Evaluation of Dietary Probiotic (Lactobacillus plantarum BG0001) Supplementation on the Growth Performance, Nutrient Digestibility, Blood Profile, Fecal Gas Emission, and Fecal Microbiota in Weaning Pigs

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