Probiotic: effectiveness nutrition in cancer treatment and prevention

Kich, Débora Mara; Vincenzi, Angélica; Majolo, Fernanda; Souza, Cláucia Fernanda Volken de; Goettert, Márcia Inês

doi:10.20960/nh.806

Cited by 19 publications

(19 citation statements)

References 96 publications

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“…Over the past three decades, probiotic potential of some bacteria has been well-recognized. The beneficial effects of probiotic bacteria are mainly associated with the maintenance of a healthy gut microbiota, an improvement of gut resilience, the modulation of lactose intolerance, bowel function, and gastrointestinal (GI) comfort, and diarrhea prevention and symptom alleviation (Licciardi et al, 2010 ; Waitzberg et al, 2015 ; Wright et al, 2015 ; Kich et al, 2016 ; Mokoena et al, 2016 ). Probiotic food products, including probiotic powders and probiotic fermented food, account for a significant part of the functional foods in market (60–70% of the total functional food in market; García-Ruiz et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Overexpression of luxS Promotes Stress Resistance and Biofilm Formation of Lactobacillus paraplantarum L-ZS9 by Regulating the Expression of Multiple Genes

Liu

Zhang

et al. 2018

Front. Microbiol.

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Probiotics have evoked great interest in the past years for their beneficial effects. The aim of this study was to investigate whether luxS overexpression promotes the stress resistance of Lactobacillus paraplantarum L-ZS9. Here we show that overexpression of luxS gene increased the production of autoinducer-2 (AI-2, quorum sensing signal molecule) by L. paraplantarum L-ZS9. At the same time, overexpression of luxS promoted heat-, bile salt-resistance and biofilm formation of the strain. RNAseq results indicated that multiple genes encoding transporters, membrane proteins, and transcriptional regulator were regulated by luxS. These results reveal a new role for LuxS in promoting stress resistance and biofilm formation of probiotic starter.

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Section: Introductionmentioning

confidence: 99%

Overexpression of luxS Promotes Stress Resistance and Biofilm Formation of Lactobacillus paraplantarum L-ZS9 by Regulating the Expression of Multiple Genes

Liu

Zhang

et al. 2018

Front. Microbiol.

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“…The results indicated the ability of living cells of mutant S.boulardii (MSb) to promot the level of IL-10 more than commercial (CSb) and local (LSb) S.boulardii. Some factors derived from S.boulardii cells walls have contributed to the enhancement and increase of the host's immune response and the balance between Th2/ Th1, which has promoted increased IL-10 production (24,25). Besides βglucan, which is derived from the walls of the dead cells of S.boulardii yeast in intestinal tract, has a strong effect in stimulating and increasing the immune response by binding to special receptors, especially in the gastrointestinal tract such as (TLR-2), Tall Like Receptor, Dectin-1 receptor and other receptors, stimulating immune cells to produce antiinflammatory cytokines IL-10 (26).…”

Section: -Effect the Sboulardii In The Levels Of Il-10 And Ifn-ɣmentioning

confidence: 99%

Effect of add exogenous fibrolytic enzymes to the ration in some characteristics of blood biochemicals of Awassi lactating ewes

Al-Rubaie

Ajeel

Khalaf

2018

AJVS

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The experiment was conducted in the field of animal production of the research ruminants- Office of Research- Ministry of Agriculture in the region of Akrokov 25 km northwest of Baghdad for the period from 16/3/2016 to 4/6/2016, and the objective of the experiment was the effect of addition of different levels of fibrolytic enzymes. The concentrate diet on some characteristics biochemical blood lactating Ewes Awassi, In the first experiment, 26 pregnant sheep were used In the late stage and before birth and at the age of 3-5 years, With a weight of 67 kg, The first experiment lasted 42 days preceded by 10 days introductory period The ewes were divided into four groups, each with 6 ewes, of which 15 were born, Treatment control 3 ewes, first treatment 5 ewes, second treatment 4 ewes, third treatment 3 ewes, The trial period was divided into three successive periods from birth every 14 days, The first period of 0-14 days and the second period of 15-28 days and the third period of 29 to 42 days of the milk cycle began, Control group without enzyme and treatment of the first, second and third enzyme concentration 1,3,5 kg/t respectively. The preliminary period is 10 days ahead, The results showed that: The addition of fibrolytic enzymes to the cencenterate diet of the fodder resulted in Significant increase (P<0.01) was observed at the general rate of concentration of urea, The concentration of urea was significantly increased only in T3, while cholesterol was significantly higher in all treatments compared to the control treatment. And significantly increased triglycerides in T2 compared to all other treatments. Very high-density lipoprotein was increased in T1 treatment with control treatment C, as well as significant increase (P≤0.05) high-density lipoprotein in treatment T1 compared to treatment control C and the recording of high-density lipoprotein (HDL) significantly higher in T2 compared to all treatments triglyceride, and very high-density lipoprotein, (P<0.05) for high density lipoprotein (LDL) and low-density lipoprotein. LDL was significantly increased in T3 compared to T1. The serum AST (T3) was significantly increased in T3 compared to T2, T1 in the serum of lactating ewes.

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“…Epidemiological studies have shown that the composition of CRC patients microbiota is different to the one present in healthy population [ 76 ]. Taking into account the effectiveness of probiotics in modulating microbiome composition, the design of microbiota-targeting therapies is now considered as a feasible strategy in the clinic, both as a preventive and a therapeutic approach [ 77 ].…”

Section: Lipid Metabolism Diet and Colorectal Cancermentioning

confidence: 99%

Precision Nutrition for Targeting Lipid Metabolism in Colorectal Cancer

2017

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Cancer is a multistage and multifactorial condition with genetic and environmental factors modulating tumorogenesis and disease progression. Nevertheless, cancer is preventable, as one third of cancer deaths could be avoided by modifying key risk factors. Nutrients can directly affect fundamental cellular processes and are considered among the most important risk factors in colorectal cancer (CRC). Red and processed meat, poultry consumption, fiber, and folate are the best-known diet components that interact with colorectal cancer susceptibility. In addition, the direct association of an unhealthy diet with obesity and dysbiosis opens new routes in the understanding of how daily diet nutrients could influence cancer prognosis. In the “omics” era, traditional nutrition has been naturally evolved to precision nutrition where technical developments have contributed to a more accurate discipline. In this sense, genomic and transcriptomic studies have been extensively used in precision nutrition approaches. However, the relation between CRC carcinogenesis and nutrition factors is more complex than originally expected. Together with classical diet-nutrition-related genes, nowadays, lipid-metabolism-related genes have acquired relevant interest in precision nutrition studies. Lipids regulate very diverse cellular processes from ATP synthesis and the activation of essential cell-signaling pathways to membrane organization and plasticity. Therefore, a wide range of tumorogenic steps can be influenced by lipid metabolism, both in primary tumours and distal metastasis. The extent to which genetic variants, together with the intake of specific dietary components, affect the risk of CRC is currently under investigation, and new therapeutic or preventive applications must be explored in CRC models. In this review, we will go in depth into the study of co-occurring events, which orchestrate CRC tumorogenesis and are essential for the evolution of precision nutrition paradigms. Likewise, we will discuss the application of precision nutrition approaches to target lipid metabolism in CRC.

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Probiotic: effectiveness nutrition in cancer treatment and prevention

Cited by 19 publications

References 96 publications

Overexpression of luxS Promotes Stress Resistance and Biofilm Formation of Lactobacillus paraplantarum L-ZS9 by Regulating the Expression of Multiple Genes

Overexpression of luxS Promotes Stress Resistance and Biofilm Formation of Lactobacillus paraplantarum L-ZS9 by Regulating the Expression of Multiple Genes

Effect of add exogenous fibrolytic enzymes to the ration in some characteristics of blood biochemicals of Awassi lactating ewes

Precision Nutrition for Targeting Lipid Metabolism in Colorectal Cancer

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