Probiotic Lactobacilli Enhance Immunogenicity of an Inactivated H9N2 Influenza Virus Vaccine in Chickens

Alqazlan, Nadiyah; Astill, Jake; Taha-Abdelaziz, Khaled; Nagy, Éva; Bridle, Byram W.; Sharif, Shayan

doi:10.1089/vim.2020.0209

Cited by 15 publications

(10 citation statements)

References 36 publications

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“…In a study, the probiotic function of Lactobacillus plantarum ( L. plantarum ) was assessed and the results showed that fecal secretory immunoglobulin A (sIgA) titer significantly increased in the probiotic group infants ( 100 ). Another study on chicken models showed that a mixture of probiotic Lactobacillus spp can enhance IFN-γ gene expression but does not influence antibody production after influenza vaccination ( 101 ). Consumption of probiotics containing Lactobacillus acidophilus; Lactobacillus plantarum; Pediococcus pentosaceus ; Saccharomyces cerevisiae ; Bacillus subtilis , and Bacillus licheniformis in broiler chickens resulted in the diminished adverse effect of live vaccine, reduced mortality rate, fecal shedding, and re-isolation of Salmonella Enteritidis (SE) from liver, spleen, heart, and cecum against SE vaccine ( 102 ).…”

Section: The Effects Of Probiotics On Vaccine Efficacymentioning

confidence: 99%

Probiotics and probiotic-based vaccines: A novel approach for improving vaccine efficacy

2022

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Vaccination is defined as the stimulation and development of the adaptive immune system by administering specific antigens. Vaccines' efficacy, in inducing immunity, varies in different societies due to economic, social, and biological conditions. One of the influential biological factors is gut microbiota. Cross-talks between gut bacteria and the host immune system are initiated at birth during microbial colonization and directly control the immune responses and protection against pathogen colonization. Imbalances in the gut microbiota composition, termed dysbiosis, can trigger several immune disorders through the activity of the adaptive immune system and impair the adequate response to the vaccination. The bacteria used in probiotics are often members of the gut microbiota, which have health benefits for the host. Probiotics are generally consumed as a component of fermented foods, affect both innate and acquired immune systems, and decrease infections. This review aimed to discuss the gut microbiota's role in regulating immune responses to vaccination and how probiotics can help induce immune responses against pathogens. Finally, probiotic-based oral vaccines and their efficacy have been discussed.

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Section: The Effects Of Probiotics On Vaccine Efficacymentioning

confidence: 99%

Probiotics and probiotic-based vaccines: A novel approach for improving vaccine efficacy

2022

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“…As a matter of fact, very recently, it has been shown that a range of probiotic bacteria increases the efficacy of vaccinations in chickens treated with a vaccine specific for Newcastle disease [ 26 ] or avian influenza H9N2 [ 27 , 28 ]. In this case, adjuvant effects have been detected by using either bacteria cells [ 9 ] or spores [ 27 ].…”

Section: Animal Vaccinationsmentioning

confidence: 99%

Probiotics as Adjuvants in Vaccine Strategy: Is There More Room for Improvement?

Peroni

Morelli

2021

Vaccines

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Background. It has been recognized that microbiota plays a key role in shaping immune system maturation and activity. Since probiotic administration influences the microbiota composition and acts as a biological response modifier, the efficacy of an adjuvant for boosting vaccine-specific immunity is investigated. Methods. A review of the literature was performed, starting from the mechanisms to laboratory and clinical evidence. Results. The mechanisms, and in vitro and animal models provide biological plausibility for microbiota use. Probiotics have been investigated as adjuvants in farm conditions and as models to understand their potential in human vaccinations with promising results. In human studies, although probiotics were effective in ameliorating seroconversion to vaccines for influenza, rotavirus and other micro-organisms, the results for clinical use are still controversial, especially in particular settings, such as during the last trimester of pregnancy. Conclusion. Although this topic remains controversial, the use of probiotics as adjuvant factors in vaccination represents a strategic key for different applications. The available data are deeply influenced by heterogeneity among studies in terms of strains, timing and duration of administration, and patients. Although these do not allow us to draw definitive conclusions, probiotics as adjuvants in vaccination should be considered in future studies, especially in the elderly and in children, where vaccine effectiveness and duration of immunization really matter.

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“…PolyI:C induces innate immune response similar to a live viral vaccine (10), interferon-alpha/beta (IFN-α/β) production, and a stable maturation of human MoDCs and CD8 + T cells immune response (11). AddaVax and PolyI:C have present promising results for influenza vaccine development (12)(13)(14)(15)(16). Mice firstly immunized with antigen emulsified in AddaVax adjuvant, and then boosted with antigen combined with AddaVax and TLR9 agonist CpG-DNA, showed a higher titer response (17) In addition, AddaVax shows antigen delivery effect (18), implying that AddaVax can be used as a carrier for other adjuvants.…”

Section: Introductionmentioning

confidence: 99%

AddaVax Formulated with PolyI:C as a Potential Adjuvant of MDCK-based Influenza Vaccine Enhances Local, Cellular, and Antibody Protective Immune Response in Mice

et al. 2021

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Poor immune responses to inactivated influenza vaccine can be improved by effective and safe adjuvants to increase antibody titers and cellular protective response. In our study, AddaVax and PolyI:C combined adjuvant (AP adjuvant) were used for influenza vaccine development. After immunizing BALB/c mice and Wistar rats intramuscularly, Split inactivated H3N2 vaccine adjuvanted with AP elicited higher serum hemagglutination-inhibition antibodies and IgG titers. We demonstrated that AP induced a transient innate immune cytokines production at the injection site, induced H3N2 uptake by DCs, increased recruitment of monocytes and DCs in LNs, and promoted H3N2 vaccine migration; AP facilitated vaccines to induce a vigorous adaptive immune response. Besides, AP showed good safety as shown by lymph nodes (LNs) size, spleens index of BALB/c mice, and weight changes and C-reaction protein level of BALB/c mice and Wistar rats after repeated administration of high-dose vaccine with or without adjuvant. These findings indicate that AP is a potential novel adjuvant and can be used as a safe and effective adjuvant for MDCK-based influenza inactivated vaccine to induce cellular and antibody protective response.

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Probiotic Lactobacilli Enhance Immunogenicity of an Inactivated H9N2 Influenza Virus Vaccine in Chickens

Cited by 15 publications

References 36 publications

Probiotics and probiotic-based vaccines: A novel approach for improving vaccine efficacy

Probiotics and probiotic-based vaccines: A novel approach for improving vaccine efficacy

Probiotics as Adjuvants in Vaccine Strategy: Is There More Room for Improvement?

AddaVax Formulated with PolyI:C as a Potential Adjuvant of MDCK-based Influenza Vaccine Enhances Local, Cellular, and Antibody Protective Immune Response in Mice

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