Probiotic Lactobacillus rhamnosus GG enhances gastric ulcer healing in rats

Lam, Emily Kai Yee; Yu, Li; Wong, Hai Ming; Wu, William Ka Kei; Shin, Vivian Y.; Tai, Emily Kin Ki; So, Wallace H.L.; Woo, Patrick C. Y.; Cho, C.H.

doi:10.1016/j.ejphar.2007.02.050

Cited by 86 publications

(78 citation statements)

References 37 publications

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“…In addition, this molecule also plays a role in angiogenesis (DeLisser et al, 1997), and therefore an upregulation could also mean an increase in perfusion of the surrounding tissue. A stimulation of angiogenesis in gastric ulcer healing by probiotic bacteria -targets of prebiotics -has been found previously (Lam et al, 2007) and may be related to the present finding.…”

Section: Discussionsupporting

confidence: 88%

Effects of the prebiotics inulin and lactulose on intestinal immunology and hematology of preruminant calves

Masanetz

Preißinger

Meyer

et al. 2011

Animal

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Prebiotics are suggested as an alternative to antibiotics in animal rearing. Fermentable substances such as inulin or lactulose have been proposed to stimulate the immune system and health by modulation of the intestinal flora and its fermentation products. In this study, effects of inulin and lactulose on the intestinal health and hematology of calves have been investigated. Both prebiotics significantly decreased thrombocyte counts in peripheral blood. Only inulin was able to increase hemoglobin concentration and hematocrit. Total leukocyte count was decreased by lactulose while both prebiotics tended to lower monocyte proportions. mRNA expression of inflammation-related markers in the intestine was also affected by both prebiotics hinting at a decreased inflammatory status. This may be due to a possible decrease in intestinal pathogen load that remains to be verified. Only mRNA amounts of interleukin 8 were increased by lactulose in mesenteric lymph nodes. In the ileum, expression of a proliferation marker was increased by inulin while an apoptosis-related gene was increased by both prebiotics. The results of this study show a clear effect of prebiotics on certain parameters associated with animal health and performance that remain to be studied in detail in future investigations.

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Section: Discussionsupporting

confidence: 88%

Effects of the prebiotics inulin and lactulose on intestinal immunology and hematology of preruminant calves

Masanetz

Preißinger

Meyer

et al. 2011

Animal

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“…Lam et al 73 showed that pre-treatment of rats with L. rhamnosus GG markedly reduced ethanol-induced mucosal lesion area and gastric cell apoptosis. Recent study demonstrated that Bifidobacterium bifidum administration reduced intestinal apoptosis in necrotizing enterocolitis (NEC) in vitro and in vivo.…”

Section: Experimental Groupsmentioning

confidence: 99%

Protective effects of probioticLactobacillus plantarumBJ0021 on liver and kidney oxidative stress and apoptosis induced by endosulfan in pregnant rats

et al. 2015

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Endosulfan (EDS) is one of the most widely organochlorine insecticide used in many parts of the world, although it is currently banned or severely restricted in use in some countries. EDS causes a variety of negative effects in non-target species including humans. Therefore, the aim of the present study was to investigate the possible protective effects of Lactobacillus plantarum BJ0021 on toxicity, oxidative stress, and apoptosis induced by EDS intoxication on liver and kidneys of pregnant rats. This pesticide induced a significant increase in total cholesterol, alanine-amino transferase (ALAT), aspartate-amino transferase (ASAT), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), urea and creatinine in serum, while urinary urea and creatinine were lower than those of the control group. In the liver and kidney, lipid peroxidation increased significantly, the antioxidant levels, such as superoxide dismutase (SOD) and catalase (CAT) were markedly depressed and TdT-mediated dUTP-biotin Nick End Labeling (TUNEL) revealed more apoptotic cells. In contrast, co-administration of L. plantarum BJ0021 to EDS-treated animals ameliorated most of these biochemical parameters, but the activity of antioxidant enzymes (SOD, CAT) did not modify and the number of apoptotic nuclei remained significantly raised in kidney compared to control. In conclusion, the administration of L. plantarum BJ0021 decreased apoptosis and might play a protective role in reducing toxicity of EDS in pregnant rats.

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“…Раніше нами був встановлений профілактичний вплив суміші пробіотичних штамів Bifidobacterium animalis VKL та Вifidobacterium animalis VKB на ерозивно-виразкові ураження в шлунку щурів, викликані стресом [5]. Проте є пові-домлення, що пробіотичні бактерії, особли-во роду Lactobacillus, швидко колонізують СОШ після утворення виразки [6,7]. Тому важливим є дослідження ефектів моноштам-них пробіотиків роду Lactobacillus, а також порівняння дії на стресіндуковані ураження моноштамних і комбінованих пробіотиків, що містять штами як Bifidobacterium, так і Вплив моно-, полі-та комбінованих пробіотиків на виразкоутворення Lactobacillus за умов різної тривалості профі-лактичного введення.…”

Section: вступunclassified

Еffects of Mono-, Poly- And Composite Probiotics on the Ulceration Caused by Restraint Stress

Virchenko¹,

Falalyeyeva²,

Tv³

et al. 2015

Fiziol Zh

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Probiotic Lactobacillus rhamnosus GG enhances gastric ulcer healing in rats

Cited by 86 publications

References 37 publications

Effects of the prebiotics inulin and lactulose on intestinal immunology and hematology of preruminant calves

Effects of the prebiotics inulin and lactulose on intestinal immunology and hematology of preruminant calves

Protective effects of probioticLactobacillus plantarumBJ0021 on liver and kidney oxidative stress and apoptosis induced by endosulfan in pregnant rats

Еffects of Mono-, Poly- And Composite Probiotics on the Ulceration Caused by Restraint Stress

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