Probiotic supplements alleviate gestational diabetes mellitus by restoring the diversity of gut microbiota: a study based on 16S rRNA sequencing

Zheng, Qing‐Xiang; Jiang, Xiu‐Min; Wang, Haiwei; Ge, Li; Lai, Yu-Ting; Jiang, Xin-Yong; Chen, Fan; Huang, Pingping

doi:10.1007/s12275-021-1094-8

Cited by 15 publications

(14 citation statements)

References 37 publications

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“…Zheng et al [ 201 ] showed that probiotic supplementation of Lactobacillus rhamnosus LGG and Bifidobacterium animalis subsp. lactis Bb12 alleviated GDM in pregnant rats and showed an improvement in fasting blood glucose levels due to restoration of the gut microbiota.…”

Section: Effect Of Probiotics On Glucose Metabolism and Homeostasismentioning

confidence: 99%

Probiotic Mechanisms Affecting Glucose Homeostasis: A Scoping Review

Pintarič

Langerholc

2022

Life

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The maintenance of a healthy status depends on the coexistence between the host organism and the microbiota. Early studies have already focused on the nutritional properties of probiotics, which may also contribute to the structural changes in the gut microbiota, thereby affecting host metabolism and homeostasis. Maintaining homeostasis in the body is therefore crucial and is reflected at all levels, including that of glucose, a simple sugar molecule that is an essential fuel for normal cellular function. Despite numerous clinical studies that have shown the effect of various probiotics on glucose and its homeostasis, knowledge about the exact function of their mechanism is still scarce. The aim of our review was to select in vivo and in vitro studies in English published in the last eleven years dealing with the effects of probiotics on glucose metabolism and its homeostasis. In this context, diverse probiotic effects at different organ levels were highlighted, summarizing their potential mechanisms to influence glucose metabolism and its homeostasis. Variations in results due to different methodological approaches were discussed, as well as limitations, especially in in vivo studies. Further studies on the interactions between probiotics, host microorganisms and their immunity are needed.

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Section: Effect Of Probiotics On Glucose Metabolism and Homeostasismentioning

confidence: 99%

Probiotic Mechanisms Affecting Glucose Homeostasis: A Scoping Review

Pintarič

Langerholc

2022

Life

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“…Probiotic therapy may be a promising approach to improve glucose control and insulin resistance among pregnant women (de Brito Alves et al, 2019;Pan et al, 2021). Previously, our results showed that Lactobacillus and Bifidobacterium probiotic supplements could reduce the fasting blood glucose level of GDM rats by restoring the diversity of gut microbiota (Zheng et al, 2021). However, the effects of probiotic supplements on gut metabolomics in GDM are unclear.…”

Section: Introductionmentioning

confidence: 81%

“…The procedures of GDM model construction and probiotics supplement can be accessed from our previous study (Zheng et al, 2021). Briefly, after adaptive feeding, 48-week-old female Sprague-Dawley rats were randomly divided into normal pregnant group that fed with ordinary feed and GDM model group that received high-fat and high-sugar feed for 6 weeks.…”

Section: Gestational Diabetes Mellitus Rats Mode and Probiotics Suppl...mentioning

confidence: 99%

Changes in the Gut Metabolic Profile of Gestational Diabetes Mellitus Rats Following Probiotic Supplementation

et al. 2022

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The roles of gut microbiota and metabolomics in women with gestational diabetes mellitus (GDM) are not well understood. This study investigated the gut metabolomic profiling of GDM rats and GDM rats treated with probiotic supplements. Associations between gut metabolites and microbiota were also studied in GDM rats. Liquid chromatography–mass spectrometry was used to detect gut metabolites in GDM rats and GDM rats treated with probiotic supplements of 0.5 g (low-dose group) or 1 g (high-dose group) for 15 days. Each gram of probiotic supplement contained 5 × 107 colony-forming units (CFU) of Lactobacillus rhamnosus LGG and 1 × 108 CFU of Bifidobacterium animalis subspecies lactis Bb12. The association between gut metabolites and microbiota in GDM rats was investigated using Spearman’s correlation. Finally, 10 rats in the normal pregnant group, eight rats in the GDM model group, eight GDM rats in the low-dose probiotics group, and nine GDM rats in the high-dose probiotics group were further studied. Serum parameters and pancreatic and colon histology were significantly changed in GDM rats, and these were restored using probiotic supplements. In total, 999 gut metabolites were detected in the feces, and GDM rats were distinguished from normal rats. The levels of 44 metabolites were increased in GDM rats, and they were alleviated using probiotic supplements. Changes in metabolites in GDM rats were associated with amino acids and bile acids metabolism signaling pathways. Furthermore, changes in metabolites after probiotic supplementation were associated with porphyrin and chlorophyll metabolism pathways. We found that the Allobaculum genus displayed strong positive correlations, whereas the Bryobacter and Gemmatimonas genera displayed strong negative correlations with metabolisms of amino acids and bile acids in GDM rats. The Lactobacillus and Bifidobacterium genera were positively correlated with gut metabolites. Overall, our results showed that metabolism signaling pathways of amino acids and bile acids are associated with the development of GDM. Probiotic supplements alleviate the pathology of GDM through the metabolism pathways of amino acids, bile acids, porphyrin, and chlorophyll.

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“…Consumption of probiotic yogurt or a multispecies probiotic mixture prevented increases in serum insulin levels and the development of insulin resistance, thereby improving glucose metabolism and glycemic control [122] , [123] . Studies have shown that probiotic supplementation can restore the diversity of the gut microbiota in rats with GDM, and the gut microbial composition was inclined to that of normal pregnant rats [124] , indicating that modulation of the gut microbiota via probiotic microorganisms could contribute to GDM prevention [125] . Furthermore, probiotic administration can also alleviate inflammation caused by insulin resistance, decreasing several inflammatory markers (such as IL-6, IL-10, TNF-α, and interferon-gamma, among others) in patients with GDM [121] .…”

Section: Female Reproductive Microbiomementioning

confidence: 99%

“… [111] L. gasseri OLL2809 Intestine Reduce pain associated with endometriosis [113] LactoFem® Intestine Reduce pain associated with endometriosis [114] L. gasseri OLL2809 Intestine Suppressed the development of ectopic endometriotic lesions [115] L. acidophilus LA5, Bifidobacterium animalis BB12 Intestine Maintained serum insulin levels and prevented developing insulin resistance in pregnant women [122] Probiotic Mixture (VSL#3) Intestine Maintained glycemic control in GDM women [123] L. rhamnosus , LGG, Bifidobacterium animalis subsp. lactis Bb12 Intestine Restored the gut microbiota of GDM rats [124] Note: HPO axis: hypothalamic-pituitary-ovarian axis; FSH: follicle-stimulating hormone; L. : Lactobacillus ; SCFAs: short-chain fatty acids; PCOS: polycystic ovary syndrome; BV: bacterial vaginosis; GDM: gestational diabetes mellitus. …”

Section: Female Reproductive Microbiomementioning

confidence: 99%