Probiotics in Children with Asthma

Allergic rhinitis (AR) is a widespread medical condition affecting up to 40% of the general population. Type 2 inflammation determines typical nasal symptoms. In addition, gut and respiratory dysbiosis are present in AR patients. Probiotics have several beneficial effects on immunity, inflammatory pathways, and anti-infective properties. Namely, probiotic supplementation could restore immune response, promote eubiosis, and switch off inflammation. Thus, probiotics have also been investigated in AR. In addition, there is accumulating evidence that some specific strains of probiotics may improve AR. Five meta-analyses on probiotics in AR management were consistently published in the first half of 2022. The conclusions, although not definitive, argue for the possible use of probiotics as part of an add-on strategy in managing patients with allergic rhinitis.

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“…Moreover, the outcomes reported in AR were substantially consistent with what has been reported in the asthma model [52][53][54].…”

Section: New Evidence In the Literaturesupporting

confidence: 83%

Probiotics in Allergic Rhinitis Management: Is There a Positioning for Them?

Ciprandi

Tosca

2022

Allergies

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“…95 Moreover, administration of Lactobacillus taiwanensis to mice inhibits the expression of immunity to H. polygyrus, by promoting a strong Treg response. 96 Thus, interactions between probiotic bacteria and the immune system seem to impair anti-helminth immunity in many models, which is perhaps consistent with the effects described for some probiotics in suppressing symptoms of allergy and asthma [97][98][99] . Moreover, these results may imply that prebiotic dietary components that stimulate the production of lactobacilli or related bacteria may also have a similar attenuating effect on the type-2 response, with clear implications for probiotic supplementation in areas of helminth endemicity.…”

Section: Probiotic Bacteria and Helminth Infectionsupporting

confidence: 71%

Diet‐microbiota crosstalk and immunity to helminth infection

Myhill

Williams

2023

Parasite Immunology

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Helminths are large multicellular parasites responsible for widespread chronic disease in humans and animals. Intestinal helminths live in close proximity with the host gut microbiota and mucosal immune network, resulting in reciprocal interactions that closely influence the course of infections. Diet composition may strongly regulate gut microbiota composition and intestinal immune function and therefore may play a key role in modulating anti‐helminth immune responses. Characterizing the multitude of interactions that exist between different dietary components (e.g., dietary fibres), immune cells, and the microbiota, may shed new light on regulation of helminth‐specific immunity. This review focuses on the current knowledge of how metabolism of dietary components shapes immune response during helminth infection, and how this information may be potentially harnessed to design new therapeutics to manage parasitic infections and associated diseases.

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“…Several studies have tried to investigate the possible role of probiotics in influencing the course of allergic pathologies such as AD, asthma, allergic rhinitis, and FAs [ 5 , 84 , 85 , 86 ]. Some studies have demonstrated the beneficial effect that probiotics have on AD; in particular, compared to a placebo, their administration caused a reduction of AD incidence and relieved AD symptoms, especially in children older than 1 year.…”

Section: Microbiotamentioning

confidence: 99%

Molecular Mechanism and Clinical Effects of Probiotics in the Management of Cow’s Milk Protein Allergy

Cela,

Brindisi,

Gravina

et al. 2023

IJMS

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Cow’s milk protein allergy (CMPA) is the most common food allergy (FA) in infancy, affecting approximately 2% of children under 4 years of age. According to recent studies, the increasing prevalence of FAs can be associated with changes in composition and function of gut microbiota or “dysbiosis”. Gut microbiota regulation, mediated by probiotics, may modulate the systemic inflammatory and immune responses, influencing the development of allergies, with possible clinical benefits. This narrative review collects the actual evidence of probiotics’ efficacy in the management of pediatric CMPA, with a specific focus on the molecular mechanisms of action. Most studies included in this review have shown a beneficial effect of probiotics in CMPA patients, especially in terms of achieving tolerance and improving symptoms.

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Probiotics in Children with Asthma

Cited by 11 publications

References 97 publications

Probiotics in Allergic Rhinitis Management: Is There a Positioning for Them?

Probiotics in Allergic Rhinitis Management: Is There a Positioning for Them?

Diet‐microbiota crosstalk and immunity to helminth infection

Molecular Mechanism and Clinical Effects of Probiotics in the Management of Cow’s Milk Protein Allergy

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