Probiotics Interactions and the Modulation of Major Signalling Pathways in Host Model Organism Caenorhabditis elegans

Mahesh, R.; Ilangovan, Prakash; Nongbri, Daniel; Suchiang, Kitlangki

doi:10.1007/s12088-021-00961-3

Cited by 7 publications

(5 citation statements)

References 87 publications

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“…50,51 The IIS pathway initiates the activation of downstream mediators and kinases and then inactivates daf-16 via phosphorylation. 52 The up-regulation of daf-2 can decrease the expression of daf-16, which is consistent with the results we observed in the wild-type KD group (Fig. 5b).…”

Section: Food and Function Papersupporting

confidence: 92%

Saccharomyces cerevisiae: a patulin degradation candidate bothin vitroandin vivo

et al. 2023

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Section: Food and Function Papersupporting

confidence: 92%

Saccharomyces cerevisiae: a patulin degradation candidate bothin vitroandin vivo

et al. 2023

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“…An abundance of genetic resources about C. elegans allows a detailed investigation of host–microbe interactions. Bacteria act as a dietary source for C. elegans , influencing its phenotype, including factors like lifespan and immune response [ 10 ]. Feeding bacteria directly to C. elegans makes it an ideal model for studying host–microbe interactions.…”

Section: Introductionmentioning

confidence: 99%

Metabolic Regulation of Longevity and Immune Response in Caenorhabditis elegans by Ingestion of Lacticaseibacillus rhamnosus IDCC 3201 Using Multi-Omics Analysis

Lee,

Eor,

Kwak

et al. 2024

J. Microbiol. Biotechnol.

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Probiotics, specifically Lacticaseibacillus rhamnosus , have garnered attention for their potential health benefits. This study focuses on evaluating the probiotic properties of candidate probiotics L. rhamnosus IDCC 3201 (3201) using the Caenorhabditis elegans surrogate animal model, a well-established in vivo system for studying host–bacteria interactions. The adhesive ability to the host’s gastrointestinal tract is a crucial criterion for selecting potential probiotic bacteria. Our findings demonstrated that 3201 exhibits significantly higher adhesive capabilities compared with Escherichia coli OP50 (OP50), a standard laboratory food source for C. elegans and is comparable with the widely recognized probiotic L. rhamnosus GG (LGG). In lifespan assay, 3201 significantly increased the longevity of C. elegans compared with OP50. In addition, preconditioning with 3201 enhanced C. elegans immune response against four different foodborne pathogenic bacteria. To uncover the molecular basis of these effects, transcriptome analysis elucidated that 3201 modulates specific gene expression related to the innate immune response in C. elegans . C-type lectin-related genes and lysozyme-related genes, crucial components of the immune system, showed significant upregulation after feeding 3201 compared with OP50. These results suggested that preconditioning with 3201 may enhance the immune response against pathogens. Metabolome analysis revealed increased levels of fumaric acid and succinic acid, metabolites of the citric acid cycle, in C. elegans fed with 3201 compared with OP50. Furthermore, there was an increase in the levels of lactic acid, a well-known antimicrobial compound. This rise in lactic acid levels may have contributed to the robust defense mechanisms against pathogens. In conclusion, this study demonstrated the probiotic properties of the candidate probiotic L. rhamnosus IDCC 3201 by using multi-omics analysis.

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“…It is imperative that probiotics are genetically unaltered and robust enough to endure travel through the GIT. Therefore, it might be possible for probiotics to alter the composition and equilibrium of the microbiota that live on the mucosal surfaces of the intestines, particularly the lumen, as probiotics have the ability to suppress the inflammation caused by gut microbes, it has already been demonstrated that probiotics can have a role in lowering inflammatory reactions in GIT, such as those caused by autoimmune illnesses (Mahesh et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Exploring the serotonin‐probiotics‐gut health axis: A review of current evidence and potential mechanisms

Akram,

Faisal,

Irfan

et al. 2023

Food Science & Nutrition

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Modulatory effects of serotonin (5‐Hydroxytryptamine [5‐HT]) have been seen in hepatic, neurological/psychiatric, and gastrointestinal (GI) disorders. Probiotics are live microorganisms that confer health benefits to their host. Recent research has suggested that probiotics can promote serotonin signaling, a crucial pathway in the regulation of mood, cognition, and other physiological processes. Reviewing the literature, we find that peripheral serotonin increases nutrient uptake and storage, regulates the composition of the gut microbiota, and is involved in mediating neuronal disorders. This review explores the mechanisms underlying the probiotic‐mediated increase in serotonin signaling, highlighting the role of gut microbiota in the regulation of serotonin production and the modulation of neurotransmitter receptors. Additionally, this review discusses the potential clinical implications of probiotics as a therapeutic strategy for disorders associated with altered serotonin signaling, such as GI and neurological disorders. Overall, this review demonstrates the potential of probiotics as a promising avenue for the treatment of serotonin‐related disorders and signaling of serotonin.

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Probiotics Interactions and the Modulation of Major Signalling Pathways in Host Model Organism Caenorhabditis elegans

Cited by 7 publications

References 87 publications

Saccharomyces cerevisiae: a patulin degradation candidate bothin vitroandin vivo

Saccharomyces cerevisiae: a patulin degradation candidate bothin vitroandin vivo

Metabolic Regulation of Longevity and Immune Response in Caenorhabditis elegans by Ingestion of Lacticaseibacillus rhamnosus IDCC 3201 Using Multi-Omics Analysis

Exploring the serotonin‐probiotics‐gut health axis: A review of current evidence and potential mechanisms

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