Probiotics promote rapid-turnover protein production by restoring gut flora in patients with alcoholic liver cirrhosis

Koga, Hironori; Tamiya, Yoshitaka; Mitsuyama, Keiichi; Ishibashi, Masahiko; Matsumoto, Satoshi; Imaoka, Akemi; Hara, Takeo; Nakano, Masanori; Ooeda, Kazutoshi; Y, Umezaki; Sata, Michio

doi:10.1007/s12072-012-9408-x

Cited by 29 publications

(38 citation statements)

References 37 publications

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“…Furthermore, the counts of Lactobacilli enriched in the stool samples of cirrhotic patients, including hydrogen peroxide-producing strains [ 96 ]. In patients with alcoholic liver cirrhosis, Enterobacteriaceae increased, while some obligate anerobic bacteria significantly decreased [ 97 ]. In addition, it was illustrated by a median 27 times more Enterobactericeae DNA was found in feces of alcoholic cirrhotic patients than healthy subjects, and Enterobactericeae was the most common bacteria translocating into the liver of the patients [ 98 ].…”

Section: Liver Fibrosis and Cirrhosismentioning

confidence: 99%

“…Probiotics and natural products have been demonstrated to promote gut flora restoring and benefit patients with cirrhosis ( Table 3 ). For example, the decreased levels of rapid-turnover proteins in the serum of patients with alcoholic liver cirrhosis were reverted by the treatment of Yakult 400, a probiotic beverage containing Lactobacillus casei strain Shirota [ 97 ]. Furthermore, a clinical trial of probiotic VSL#3 (daily for 6 months) was carried out in Indian patients with HE, and the result showed that probiotic VSL#3 reduced the severity of liver cirrhosis and hospitalization [ 103 ] In another study, VSL#3 was administrated to some Polish patients with liver cirrhosis in a short period (daily for 28 days) [ 104 ].…”

Section: Liver Fibrosis and Cirrhosismentioning

confidence: 99%

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Gut Microbiota’s Relationship with Liver Disease and Role in Hepatoprotection by Dietary Natural Products and Probiotics

Meng

et al. 2018

Nutrients

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A variety of dietary natural products have shown hepatoprotective effects. Increasing evidence has also demonstrated that gut microorganisms play an important role in the hepatoprotection contributed by natural products. Gut dysbiosis could increase permeability of the gut barrier, resulting in translocated bacteria and leaked gut-derived products, which can reach the liver through the portal vein and might lead to increased oxidative stress and inflammation, thereby threatening liver health. Targeting gut microbiota modulation represents a promising strategy for hepatoprotection. Many natural products could protect the liver from various injuries or mitigate hepatic disorders by reverting gut dysbiosis, improving intestinal permeability, altering the primary bile acid, and inhibiting hepatic fatty acid accumulation. The mechanisms underlying their beneficial effects also include reducing oxidative stress, suppressing inflammation, attenuating fibrosis, and decreasing apoptosis. This review discusses the hepatoprotective effects of dietary natural products via modulating the gut microbiota, mainly focusing on the mechanisms of action.

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Section: Liver Fibrosis and Cirrhosismentioning

confidence: 99%

Section: Liver Fibrosis and Cirrhosismentioning

confidence: 99%

Gut Microbiota’s Relationship with Liver Disease and Role in Hepatoprotection by Dietary Natural Products and Probiotics

Meng

et al. 2018

Nutrients

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“…Recently, Okubo et al demonstrated that LcS reduced the plasma levels of bacterial lipopolysaccharide and changed the composition of the gut microbiota in an animal model of hepatic steatosis [ 17 ]. On the other hand, LcS has been reported to exhibit beneficial effects via anti-inflammatory actions against inflammatory bowel disease [ 28 ], arthritis [ 29 ], and type 1 diabetes [ 30 ] in some animal models and alcoholic liver cirrhosis patients [ 31 ]. Thus, the reduction of intestinal permeability and the anti-inflammatory activity may influence pancreatic β cell function.…”

Section: Discussionmentioning

confidence: 99%

Effect of <i>Lactobacillus casei</i> strain Shirota-fermented milk on metabolic abnormalities in obese prediabetic Japanese men: a randomised, double-blind, placebo-controlled trial

Naito

Yoshida

Kunihiro

et al. 2018

Bioscience of Microbiota, Food and Health

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An obesity-related prediabetic state is characterised by metabolic abnormalities such as post-glucose load hyperglycaemia and dyslipidaemia and consequently increases the risk for type 2 diabetes and cardiovascular disease. This study aimed to investigate the effects of Lactobacillus casei strain Shirota (LcS) on metabolic abnormalities in obese prediabetic subjects in a randomised, double-blind, placebo-controlled trial. Herein, 100 obese subjects (body mass index ≥25), who had moderate post-load hyperglycaemia (1-hr post-load plasma glucose (PG) levels ≥180 mg/dl during the oral glucose tolerance test), consumed LcS-fermented milk or placebo milk daily for 8 weeks. The post-load PG and fasting blood markers were evaluated. Although post-load PG levels were not significantly different between the groups, 1-hr post-load PG, glycoalbumin, and HbA1c levels decreased at 8 weeks compared with the baseline levels only in the LcS group (p=0.036, p=0.002, and p=0.006, respectively). The reduction in glycoalbumin levels was statistically significantly greater in the LcS group than in the placebo group (p=0.030). Stratified analyses revealed significantly improved 1-hr post-load PG and glycoalbumin levels in the LcS group compared with the placebo group among subjects with severe glucose intolerance (2-hr post-load PG levels higher than the median at baseline; p=0.036 and p=0.034, respectively). In terms of lipidic outcomes, total, low-density lipoprotein, and non-high-density lipoprotein cholesterol levels were significantly lower in the LcS group than in the placebo group (p=0.023, p=0.022, and p=0.008, respectively). These findings suggest that LcS may favourably affect metabolic abnormalities in obese prediabetic subjects, though the effects on glycaemic control may be limited.

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“…One trial did show a change in beta-diversity (relative contributions of the various species)[78]; however, virtually all studies which have shown changes in fecal microbial composition during probiotic administration were done in babies, for example preterm infants[79,80]. One study that did show that a probiotic could alter the fecal microbiota focused on older children with cystic fibrosis[81] and another showed changes in adults with alcoholic cirrhosis[82]. Most of these trials used quantitative polymerase chain reaction (PCR), rather than 16S ribosomal RNA gene sequencing.…”

Section: Targeting the Gut Microbiome As A Potential Treatment For Chmentioning

confidence: 99%

Can probiotics benefit children with autism spectrum disorders?

Navarro¹,

Liu²,

Rhoads³

2016

WJG

135

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Children with autism are commonly affected by gastrointestinal problems such as abdominal pain, constipation and diarrhea. In recent years, there has been a growing interest in the use of probiotics in this population, as it hypothetically may help to improve bowel habits and the behavioral and social functioning of these individuals. The gut microbiome plays an important role in the pathophysiology of organic as well as functional gastrointestinal disorders. Microbial modification with the use of antibiotics, probiotics, and fecal transplantation have been effective in the treatment of conditions such as recurrent Clostridium difficile infection, pouchitis, and irritable bowel syndrome. The present review presents a number of reported clinical, immunological and microbiome-related changes seen in children with autism compared to normally developed children. It also discusses gut inflammation, permeability concerns, and absorption abnormalities that may contribute to these problems. Most importantly, it discusses evidence, from human and animal studies, of a potential role of probiotics in the treatment of gastrointestinal symptoms in children with autism.

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Probiotics promote rapid-turnover protein production by restoring gut flora in patients with alcoholic liver cirrhosis

Abstract: This is the first report describing the unique gut flora of ALC patients. Y400 treatment normalized the gut flora and improved liver function. These promising findings warrant further investigation in larger, multicenter studies.

Cited by 29 publications

References 37 publications

Gut Microbiota’s Relationship with Liver Disease and Role in Hepatoprotection by Dietary Natural Products and Probiotics

Gut Microbiota’s Relationship with Liver Disease and Role in Hepatoprotection by Dietary Natural Products and Probiotics

Effect of <i>Lactobacillus casei</i> strain Shirota-fermented milk on metabolic abnormalities in obese prediabetic Japanese men: a randomised, double-blind, placebo-controlled trial

Can probiotics benefit children with autism spectrum disorders?

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