Probiotics with ameliorating effects on the severity of skin inflammation in psoriasis: Evidence from experimental and clinical studies

Atabati, Hadi; Esmaeili, Seyed‐Alireza; Saburi, Ehsan; Akhlaghi, Maedeh; Raoofi, Amir; Rezaei, Nima; Momtazi‐Borojeni, Amir Abbas

doi:10.1002/jcp.29737

Cited by 31 publications

(21 citation statements)

References 117 publications

(168 reference statements)

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“…and Staphylococcus spp. are important components of the skin microbiome ( Grice et al., 2009 ; Mrázek et al., 2019 ), and some studies have confirmed their positive roles in regulating skin immune balance by generating active metabolites ( Mu et al., 2018 ; Atabati et al., 2020 ). Studies have reported that Lactobacillus and Staphylococcus modulate skin immunity by producing active metabolites such as lipoteichoic acid and prevent the adhesion and colonization of pathogens ( Cogen et al., 2008 ; Bodera and Chcialowski, 2009 ; Lai et al., 2009 ; Atabati et al., 2020 ).…”

Section: Discussionmentioning

confidence: 99%

“…Commensal microbiota on the skin are involved in both innate and adaptive immunity and maintain the integrity of the skin barrier against pathogens ( Cogen et al., 2008 ; Dréno et al., 2016 ; Zhai et al., 2018 ; Chaudhari et al., 2020 ; Flowers and Grice, 2020 ). For instance, Lactobacillus acidophilus secretes antibacterial agents on the skin and prevents the adhesion of pathogens, whereas Staphylococcal species can inhibit the Toll-like receptor-dependent pathway and modulate inflammation on the skin ( Coconnier et al., 2000 ; Lai et al., 2009 ; Atabati et al., 2020 ; Williams et al., 2020 ). Major technical and analytical breakthroughs have enabled scientists to investigate the microbiome at the genetic level, and studies have demonstrated that the influence of nonculturable microorganisms on the skin ecosystem is often underestimated ( Chen et al., 2018 ; Flowers and Grice, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

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Imbalanced Dermic Microbiome Aggravates Inflammation in Toenail Paronychia

Liu

Xue

et al. 2021

Front. Cell. Infect. Microbiol.

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The commensal microbiome influences skin immunity, but its function in toenail health remains unclear. Paronychia is one of the most common inflammatory toenail diseases, but antibiotic treatment is seldom effective in clinical cases. In this study, we performed 16S rRNA sequencing to investigate the characteristics of microbes associated with paronychia in order to identify the key microorganisms involved in inflammation. Seventy dermic samples were collected from patients with paronychia and the differences in dermic microbiota were analyzed in patients with different inflammation severities. Distinct clustering of dermal microbiota was observed in the dermis with different inflammation severities. A higher relative abundance of anaerobic microorganisms such as Parvimona, Prevotella, and Peptoniphilus was observed in severe paronychia, whereas Lactobacillus disappeared with disease progression. Co-occurring network analysis suggested that the disturbance of the dermic microbiome and attenuation of antagonism by Lactobacillus against anaerobic pathogens may aggravate inflammation in paronychia. Functional analysis showed that dermic microbiome disturbance may worsen microbial metabolism and tissue repair in the skin. In conclusion, we revealed that an increased abundance of anaerobic microorganisms and loss of Lactobacillus in the dermis may promote paronychia progression and microbiological imbalance may aggravate inflammation in patients with paronychia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Imbalanced Dermic Microbiome Aggravates Inflammation in Toenail Paronychia

Liu

Xue

et al. 2021

Front. Cell. Infect. Microbiol.

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“…It is reported that oral administration of Lactobacillus pentosus GMNL-77 could effectively treat skin inflammation due to imiquimod treatment in mice. The researchers further found that Lactobacillus pentosus GMNL-77 also ameliorated erythematous scaling lesions in psoriatic mice due to imiquimod treatment [ 104 ]. This experiment provided a theoretical basis for probiotic products to improve psoriasis.…”

Section: Probiotics Gut Microbiome Immunity and People’s Lifementioning

confidence: 99%

Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity

2021

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Probiotics are beneficial active microorganisms that colonize the human intestines and change the composition of the flora in particular parts of the host. Recently, the use of probiotics to regulate intestinal flora to improve host immunity has received widespread attention. Recent evidence has shown that probiotics play significant roles in gut microbiota composition, which can inhibit the colonization of pathogenic bacteria in the intestine, help the host build a healthy intestinal mucosa protective layer, and enhance the host immune system. Based on the close relationship between the gut microbiota and human immunity, it has become an extremely effective way to improve human immunity by regulating the gut microbiome with probiotics. In this review, we discussed the influence of probiotics on the gut microbiota and human immunity, and the relationship between immunity, probiotics, gut microbiota, and life quality. We further emphasized the regulation of gut microflora through probiotics, thereby enhancing human immunity and improving people’s lives.

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“…Probiotics are defined as live microorganisms with healthy beneficial to host if up taken in adequate amounts [ 10 , 11 ]. Recent advances have highlighted the beneficial outcome in the pathology of inflammatory disorders after using gastrointestinal bacteria therapeutically [ 12 ]. Much evidence suggests that probiotic uptake has beneficial effects on blood glucose through different mechanisms [ 13 – 16 ].…”

Section: Introductionmentioning

confidence: 99%

Gut micobiota alteration by Lactobacillus rhamnosus reduces pro-inflammatory cytokines and glucose level in the adult model of Zebrafish

et al. 2021

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Objective Type 2 diabetes mellitus (T2DM) is still a challenge for physicians to manage patient’s circumstances. It is assumed that alterations in the normal flora may be involved in the pathogenesis of T2DM through inducing chronic inflammation. To investigate the effect of Lactobacillus rhamnosus as a common probiotic on T2DM, we induced an experimental model of T2DM in adult male Zebrafish by gradient hyper-glucose accumulation methodology. Results In this trial 3-month old male adult Zebrafish were divided in to four groups including two control groups and T2DM induced groups with or without probiotic treatment. After 5 days of acclimation, T2DM was induced by a gradient hyper-glucose accumulation methodology. Diabetic fishes had statistically abnormal blood glucose and pro-inflammatory cytokine levels compared to control group (p = 0.0001). These results suggest that probiotic intervention decreased the blood glucose level in the T2DM-P group by decreasing pro-inflammatory cytokines responsible for signaling in T2DM therapeutic modalities.

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Probiotics with ameliorating effects on the severity of skin inflammation in psoriasis: Evidence from experimental and clinical studies

Cited by 31 publications

References 117 publications

Imbalanced Dermic Microbiome Aggravates Inflammation in Toenail Paronychia

Imbalanced Dermic Microbiome Aggravates Inflammation in Toenail Paronychia

Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity

Gut micobiota alteration by Lactobacillus rhamnosus reduces pro-inflammatory cytokines and glucose level in the adult model of Zebrafish

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