Some skills need to be developed in the 21st century, namely communication, collaboration, critical thinking and problem solving, and creativity. SETS is an approach in learning activities that consists of four components, namely science, technology, environment, and society. This approach is applied in learning activities in increasing critical thinking of students. The method of this research is qualitative-descriptive by reviewing 20 journals. The results of the study show that there are applications of the SETS approach integrated with other learning models and methods in learning. SETS approach link subject with daily life problems, use science to analyze the problem, use technology to design the problem solving, and consider the impacts on the environment and society. The integrations are proven can increase critical thinking of students. Further research should be more creative to apply SETS approach by designing and integrating it with other learning models, so it will be effective to develop critical thinking of students.