Problems Assessing Nonserious Adverse Drug Reactions: Antidepressant Drug Therapy and Sexual Dysfunction

Michels, Karin B.

doi:10.1592/phco.19.6.424.31048

Cited by 11 publications

(7 citation statements)

References 30 publications

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“…8,9 SD has also been attributed to other physical, clinical factors and psychological factors. 5,[10][11][12][13][14][15][16][17][18][19] Research on erectile dysfunction patients indicate that SD has significant adverse effects on both physical and mental health dimensions of quality of life (QOL). [20][21][22][23][24] Sexual dysfunction data for Asian populations are scant and primarily clinic-based.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of male and female sexual problems, perceptions related to sex and association with quality of life in a Chinese population: a population-based study

2005

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The prevalence of sexual problems (SP) and sexual satisfaction and their associations with sexrelated perceptions and quality of life (QOL) were investigated by interviewing 3257 and 1568 Chinese adults in Hong Kong by a specially designed computerized telephone-interviewing method. SP was prevalent among male (50.9%) and female (54%) respondents; approximately 50% were dissatisfied with their sexual life. Of respondents, 23.9% of men and 5.9% of women perceived sex as important and 52.5% for men and 33.8% of women reported adequate sexual knowledge. The prevalence of SP ranged from 3.4% (pain) to 29.7% (premature orgasm) for men and 6.9% (anxiety) to 24.7% (lack of interest) for women. Prevalence of erectile and lubrication problems were 9.6 and 23.6%, respectively. Sex-related knowledge, perceived importance of sex, perceived physical health status, sexual satisfaction were predictors of SP. Gender differences and strong cultural influences appear to exist. Moreover, SP and sexual satisfaction were associated with mental health and vitality QOL and overall life satisfaction. IntroductionRecent studies have showed that sexual dysfunctions are common in both sexes. [1][2][3][4] A study in the US estimated the prevalence of sexual dysfunction (SD) to be 43% among women and 31% among men. 5 An analysis of 22 general population surveys conducted in western countries summarized estimates of SD prevalence for men (inability to achieve orgasm: 5%, premature ejaculation: 35%, inhibited sexual excitement: 10-20% and inhibited sexual desire: 1-15%) and for women (inability to achieve orgasm: 5-30% and inhibited sexual desire: 1-35%). 6 Similarly, a large-scale international collaboration of multidisciplinary experts reported that 40-45% of adult women and 20-30% of adult men suffer from at least one SD. 7 It also reported the following prevalence rates among women: low levels of sexual interest at 17-55%, lubrication difficulties about 8-15%, orgasmic dysfunction at 25% and vaginismus at approximately 6%. The prevalence of erectile dysfunction was reported to be 1-9% among young males under 40 y old and rapidly increased with age to 20-40% among males between the ages of 60-69 y. 7 Age, lower education, socioeconomic status, perceived health, diabetes, heart disease and hypertension were found to be important determinants of erectile dysfunction in men. 8,9 SD has also been attributed to other physical, clinical factors and psychological factors. 5,[10][11][12][13][14][15][16][17][18][19] Research on erectile dysfunction patients indicate that SD has significant adverse effects on both physical and mental health dimensions of quality of life (QOL). [20][21][22][23][24] Sexual dysfunction data for Asian populations are scant and primarily clinic-based. [25][26][27][28][29][30] Moreover, little is known about the prevailing attitudes and perceptions of sexual problems (SP) or its effects on QOL in Asian populations. Few large-scale, population-based studies on SP have been reported in Chinese population study. The study i...

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Section: Introductionmentioning

confidence: 99%

Prevalence of male and female sexual problems, perceptions related to sex and association with quality of life in a Chinese population: a population-based study

2005

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“…6 These studies were primarily based on clinical samples. [7][8][9] Likewise, while it is known that factors including physical, [10][11][12] and mental health, 13 quality of life, 3 stress, 3 substance use, [14][15][16][17][18] frequency of exercising, 19 etc, were associated with SP in heterosexual populations, little is known about similar associations in the homosexual populations.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and factors of sexual problems in Chinese males and females having sex with the same-sex partner in Hong Kong: a population-based study

2005

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A cross-sectional, anonymous telephone survey was conducted to examine sexual problem (SP) among sexually active, Chinese homosexual adults in Hong Kong. Of the homosexual respondents, 49.1% of males and 75.6% of females reported at least one SP, of whom 36.0 and 65.7% of the males and females, respectively, felt very bothered by the SP. The prevalence of SP ranged from 3.6% (pain) to 21.8% (premature orgasm) for men and from 16.9% (anxiety) to 39.3% (lubrication problems) for females. Female homosexuals were less likely to be satisfied with their sex life and more bothered by an SP than heterosexual females and homosexual males. There were few significant differences between homosexual and heterosexual males. Female homosexuals were also more likely than male homosexuals to experience lack of orgasm and pain during intercourse. Being bothered by SP was associated with erectile dysfunction among homosexual men and lubrication problems and lack of pleasure among the homosexual women. As most of the available services related to sexual health have been directed towards heterosexuals, a service gap may exist for homosexuals. A population-based study estimated that about 4.6% of the Hong Kong male general population had had homosexual behaviors with another man in their lifetime (2.0% in the last six months).20 These estimates are comparable to those obtained in the US and UK. [21][22][23][24][25] Prevalence of homosexual behaviors among females has been reported in western countries but not in Chinese populations.The study investigated the prevalence of various types of SP and sexual satisfaction in the Chinese male and female homosexual populations in Hong Kong and compared these prevalence with those obtained from the heterosexual populations in Hong Kong. To the authors' knowledge, such comparative studies have not been reported. Factors predicting SP and sexual satisfaction were also identified; similar studies have not been reported in the Chinese population. MethodsA random telephone survey was conducted from January to April 2002. Almost 100% of the Hong Kong households have telephones. 26 All interviews were conducted between 1800 and 2230 to avoid undersampling of employed household members. Unanswered telephone calls were given at least three attempts before being classified as invalid. Initially, a total of 1571 men and 3257 women of age 18-59 years were interviewed (half of the male sample was used for an HIV study unrelated to this study); 1281 men and 2130 women were sexually active (had a sex partner in the last 12 months), out of which 55 and 95 sexually active men and women reported a same-sex partner in the last 12 months were identified and their data were analyzed in this study. We are using the term homosexual men and women in this paper to allow for easier reading, though some may argue that the adjective 'homosexual' may have other meanings. Data obtained from the heterosexual men and women were reported elsewhere. 27The interviewer first asked some nonsensitive questions (Part I) to facilita...

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“…Access to reliable data on prevalence of sexual dysfunction with the use of antidepressants can improve clinicians’ decision-making and patient care. [13] We found possible relation of antidepressants in causing sexual dysfunction, accounting for mild to moderate severity ADR. Although there was no way to prevent it, all the sexual dysfunctions found in our study were manageable with pharmacotherapy.…”

Section: Case Reportsmentioning

confidence: 98%

“…[12] As it is a nonserious adverse drug reaction (ADR), antidepressant-induced sexual dysfunction is less often studied and reported. However, it is an important problem for patients which affects their quality of life[13] and also the compliance to drug treatment – and hence, we wanted to study the prevalence of sexual dysfunction in the psychiatry unit of our tertiary care hospital and assess them for Causality, severity and preventability.…”

Section: Introductionmentioning

confidence: 99%

Sexual dysfunction with the use of antidepressants in a tertiary care mental health setting - a retrospective case series

Lahon

Shetty

Paramel

et al. 2011

Journal of Pharmacology and Pharmacotherapeutics

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Sexual dysfunction affects patients’ quality of life. It can occur secondary to physical or mental disorders, substance abuse and treatment with prescription drugs like antidepressants. We wanted to study the prevalence of sexual dysfunction associated with antidepressant use in the psychiatric unit of a tertiary care hospital and assess for causality, severity and preventability. We did a retrospective data collection from case records of patients on antidepressants from the Psychiatry outpatient clinic of a tertiary care teaching hospital during the period 1st January 2006 to 31st December 2006, excluding those with complaints of sexual dysfunction prior to treatment. Data are presented as a case series. Documented adverse events were subjected to analysis for causality, severity and preventability using Naranjo's, modified Hartwig and Siegel and modified Schumock and Thornton's Preventability scales respectively. Out of 169 patients, four patients developed sexual dysfunction (2.36%) associated with duloxetine, mirtazapine, trazodone and sertraline. We observed a possible causal relationship of mild to moderately severe ADR (sexual dysfunction) which was not preventable. Prevalence of antidepressant associated sexual dysfunction was lower than quoted in Western literature probably due to the retrospective nature of our study design. Active monitoring and intervention can greatly improve the quality of life and compliance to treatment.

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Problems Assessing Nonserious Adverse Drug Reactions: Antidepressant Drug Therapy and Sexual Dysfunction

Cited by 11 publications

References 30 publications

Prevalence of male and female sexual problems, perceptions related to sex and association with quality of life in a Chinese population: a population-based study

Prevalence of male and female sexual problems, perceptions related to sex and association with quality of life in a Chinese population: a population-based study

Prevalence and factors of sexual problems in Chinese males and females having sex with the same-sex partner in Hong Kong: a population-based study

Sexual dysfunction with the use of antidepressants in a tertiary care mental health setting - a retrospective case series

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