A significant crop failure in the last few years in the Stavropol Territory, the coronavirus pandemic, and political sanctions have a complex effect on industrial activity and the investment climate in the region and the country as a whole. Many representatives of the agro-industrial sector suffer significant losses in the territories, or completely stop their activities in agricultural production. The most difficult thing is for small and medium-sized agricultural enterprises, a significant part of which are not able to continue their activities without state support. The programs to strengthen agriculture being implemented at the federal and regional levels, as a rule, make life easier only for large agricultural enterprises. But as statistics show, representatives of small and medium-sized agribusiness in aggregate can bring up to half of the products produced in the country in certain segments of the agricultural market, which confirms the importance of providing comprehensive government assistance to such market participants. Such support for business, especially given the agricultural focus of the Stavropol Territory, will undoubtedly change the current socio-economic situation in the region in a positive direction. The financial, organizational and other problems identified in this article, as well as the ways to solve them, are based on the analysis of data from a wide range of representatives of both state bodies and public agricultural organizations. Over time, their implementation is designed to improve the socio-economic situation of the Stavropol Krai and significantly increase its agricultural position at the country level.