Procalcitonin and C-reactive protein kinetics in postoperative pediatric cardiac surgical patients

Perfil clínico da resposta inflamatória sistêmica após cirurgia cardíaca pediátrica com circulação extracorpórea

“…Despite the fact that cases of infection in the immediate postoperative period were retrospectively rejected, dosages of serum procalcitonin could be useful for these patients as a means of excluding infections 30,31 . These factors were minimized through a selection criterion, in which patients that underwent elective surgeries and that presented no preoperative factors that could unleash SIRS were chosen.…”

Granulocyte-colony stimulating factor suppresses early inflammatory response of striatum in a cardiopulmonary bypass-circulatory arrest model of ischemic brain injury in newborn piglets

“…The severity of these abnormalities can be influenced by many factors, including the type of congenital heart defect, duration of CPB and the degree of inflammatory responses resulting from the release of endotoxin and increased levels of cytokines during the CPB [4][5][6][7]. Several studies have shown that the inflammatory cytokines such as IL-6, CRP, IL-10, and IL-8 can significantly increase in infants and children after CPB [8][9][10][11] and that these increases can contribute to postoperative morbidity and mortality. It had been suggested that elevation of these proteins may be predicttive of subsequent cognitive dysfunction [12,13].…”

C-reactive protein in the diagnosis of postoperative infection in pediatric patients: a prospective observational study of 103 patients

“…Serum CRP concentration is greater than 0.08 mg/ dL in normal conditions with a half-life of approximately 19 hours [10]. During inflammatory conditions, such as trauma or infection, CRP levels begin to rise 4 to 6 hours after insult with a peak at 72 hours, after which its concentrations decline progressively if the stimulus abates [10][11][12][13][14][15][16][17]. Studies performed in critically ill medical patients use CRP values of greater than 8 to 10 mg/dL as an indicator of infection [11,12], establishing a sure diagnosis of sepsis when CRP levels greater than 50 mg/dL are detected [12].…”

“…Studies performed in critically ill medical patients use CRP values of greater than 8 to 10 mg/dL as an indicator of infection [11,12], establishing a sure diagnosis of sepsis when CRP levels greater than 50 mg/dL are detected [12]. However, the use of CRP as a marker of infection in patients undergoing surgery is controversial owing to the increase in CRP levels during the first days after surgery because of the inflammatory response secondary to the intervention [3,4,[11][12][13][14][15][16][17][18][19]. Furthermore, studies carried out in pediatric patients have obtained different results for CRP as a marker of infection [11,16,17,20].…”

“…However, the use of CRP as a marker of infection in patients undergoing surgery is controversial owing to the increase in CRP levels during the first days after surgery because of the inflammatory response secondary to the intervention [3,4,[11][12][13][14][15][16][17][18][19]. Furthermore, studies carried out in pediatric patients have obtained different results for CRP as a marker of infection [11,16,17,20]. On these grounds, we have described the kinetics of CRP in pediatric patients after major surgery to analyze the usefulness of CRP as a marker of infection in these patients compared with other markers of infection used in daily clinical practice.…”