Procalcitonin as a Diagnostic and Prognostic Marker of Sepsis in Critically Ill Patients in Intensive Care Unit

Abstract

Background: Sepsis is a leading cause of mortality in critically ill patients. However, differentiating sepsis from non-infectious triggers of the systemic inflammatory response syndrome (SIRS) is difficult. Procalcitonin is useful biomarker of systemic inflammatory response to infection. Its level rises in response to a proinflammatory stimulus, especially of bacterial origin and not rise significantly with viral or non infectious inflammation. Objectives: The aim of this study was to determine the relation of procalcitonin (PCT) level with the development of organ failure and mortality in critically ill septic ICU patients Patients and Methods: The current study was conducted on 60critically ill adult septic patients aged between 18-60 years old of both sex with anticipated stay of >48 hours. All patients were assessed clinically with haemodynamic and full laboratory monitoring, CRP, a PCT level and SOFA score were calculated in the1 st and the 4 th day of admission.Results: There was significant increase in PCT level between three groups and no significant difference between groups as regard CRP. According to SOFA score there was significant difference between three groups. There was a positive correlation between PCT level and SOFA Score (r = 0.924, P = 0.001) while there was no correlation between CRP and SOFA score (r =-0.233, P = 0.091). Conclusion: PCT is a good diagnostic and prognostic marker of sepsis. PCT shows a closer correlation than that of CRP with the severity of infection and organ dysfunction.

Clinical significance of the detection of procalcitonin and C-reactive protein in the intensive care unit

“…Univariate Cox regression analysis also manifested that PCT and CRP might be risk factors for the poor prognosis of patients with sepsis. Studies of Savva et al ( 19 ), and Ashour et al ( 20 ) proved that soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) and PCT have very good effects in assessing the severity of sepsis. Currently, there is little research on the value of CRP in assessing the severity of sepsis.…”

Higher accuracy of concurrent use of corrected QT interval and procalcitonin serum level to predict sepsis related mortality in ICU patients

“…Depending on the previous study George et al, 2015 [19] who found that frequency of adverse outcome was (58/174, 33.3%), while the frequency of prolonged QTc among cases with favorable prognosis (25/116, 46.6%) and cases with adverse prognosis (27/58, 21.6%). Moreover, depending on Ashour et al, 2017 [20] who found that frequency of mortality (18/42, 42.9%), while procalcitonin among non-survivors and survivors 8.20 ± 2.17 and 4.54 ± 1.91 respectively. Assuming the power = 0.80 and α = 0.05, and by using PASS 11 th release the minimal sample size for s single group cohort is 120 cases [21].…”