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Background Cigarette smoking is an important modifiable risk factor in kidney disease progression. Although long-term smoking has been associated with chronic kidney disease (CKD), its effect on kidney function in early stages has not been clarified. Objective To detect the early effects of smoking either active or passive on kidney functions. Methodology The current study was comparative cross sectional study conducted on 280 participants, 140 were non‑smokers and 140 were smokers (70 passive smokers and 70 active smokers). The two groups were comparable in terms of all parameters. We investigated the possible effects of smoking on kidney functions using both serum kidney function tests especially; serum urea, serum creatinine, serum cotinine levels and detection of albumin in urine. Smoking history, full Laboratory investigations, Ventilatory function test including (FEV1/FVC, FEV1, FEF 25–75%, VC and FVC) were done. Results Serum urea, serum creatinine, serum cotinine levels and urinary albumin were statistically significant higher in smokers group in comparison to nonsmokers, also the serum cotinine levels and urinary albumin were statistically significant in active smokers in comparison to passive smokers. There were positive correlations between the level of urinary albumin and pack/year (r = 0.9, p<0.05), smoking index (r = 0.9, p<0.05), smoking duration (r = 0.4, p<0.05), and serum cotinine (r = 0.6, p<0.050) with good statistical significance. The most significant predictive risk factors of microalbuminuria among smokers group in descending orders were active smoking, passive smoking, age and serum cotinine level. Conclusion Both active and passive smoking, especially among heavy smokers, is a significant risk factor for microalbuminuria. This finding increase the importance of early cessation of smoking in order to minimize early renal affection among healthy smokers that may not be discovered by routine renal function tests.

Background: Sepsis is a leading cause of mortality in critically ill patients. However, differentiating sepsis from non-infectious triggers of the systemic inflammatory response syndrome (SIRS) is difficult. Procalcitonin is useful biomarker of systemic inflammatory response to infection. Its level rises in response to a proinflammatory stimulus, especially of bacterial origin and not rise significantly with viral or non infectious inflammation. Objectives: The aim of this study was to determine the relation of procalcitonin (PCT) level with the development of organ failure and mortality in critically ill septic ICU patients Patients and Methods: The current study was conducted on 60critically ill adult septic patients aged between 18-60 years old of both sex with anticipated stay of >48 hours. All patients were assessed clinically with haemodynamic and full laboratory monitoring, CRP, a PCT level and SOFA score were calculated in the1 st and the 4 th day of admission.Results: There was significant increase in PCT level between three groups and no significant difference between groups as regard CRP. According to SOFA score there was significant difference between three groups. There was a positive correlation between PCT level and SOFA Score (r = 0.924, P = 0.001) while there was no correlation between CRP and SOFA score (r =-0.233, P = 0.091). Conclusion: PCT is a good diagnostic and prognostic marker of sepsis. PCT shows a closer correlation than that of CRP with the severity of infection and organ dysfunction.

A novel photodetector, based on Cu2ZnSnS4, CZTS, is deposited on Cu/CuFeO2 for wavelength and light power intensity detection. The preparation of CuFeO2 is carried out by the direct combustion of Cu foil wetted with Fe(NO3)2 solution. The preparation of CZTS is carried out using the hydrothermal method, then it is dropped on CuFeO2 using the drop casting method at 70 °C. Various analyses are used to look at the chemical, morphological, and optical aspects of the Cu/CuFeO2/CZTS, such as UV–vis, SEM, TEM, selected-area electron diffraction, and XRD, in which all characteristic peaks are confirmed for the prepared materials. The Cu/CuFeO2/CZTS thin film’s SEM image has a homogeneous morphology, with particles that are around 350 nm in size, demonstrating a significant improvement in morphology over Cu/CuFeO2/CZTS thin film. The TEM analysis verified the nanostructured morphology of Cu/CuFeO2/CZTS. From XRD analysis of Cu/CuFeO2/CZTS, the high intensity of the generated peaks indexed to hexagonal (2H) CuFeO2 and kesterite CZTS crystal structures revealed a compact highly crystal material. From optical analysis, CZTS, Cu/CuFeO2, and Cu/CuFeO2/CZTS thin films recoded band gaps of 1.49, 1.75, and 1.23 eV, respectively. According to the band gap measurements, the optical absorption of the Cu/CuFeO2/CZTS photodetector has clearly increased. The Cu/CuFeO2/CZTS as photodetector has a detectivity (D) and responsivity (R) of 1.7 × 1010 Jones and 127 mAW−1, respectively. Moreover, the external quantum efficiency (EQE) is 41.5% at 25 mW·cm−2 and 390 nm. Hence, the prepared Cu/CuFeO2/CZTS photodetector has a very high photoelectrical response, making it very promising as a broadband photodetector.

Background Toll-like receptors (TLRs) play an important role in activation of innate and adaptive immune responses. Aim We aimed to detect the association between TLR2 rs5743708 G>A and TLR9 rs5743836 C>T variants and COVID-19 disease susceptibility, severity, and thrombosis by using neutrophil extracellular traps (NETs). Subjects and Methods We included 100 adult COVID-19 patients as well as 100 age- and gender-matched normal controls. Participants were genotyped for TLR2 rs5743708 and TLR9 rs5743836. Citrullinated Histone (H3) was detected as an indicator of NETs. Results The mutant (G/A and C/C) genotypes and (A and C) alleles of TLR2 rs5743708 and TLR9 rs5743836, respectively, have been significantly related to a higher risk of COVID-19 infection, representing a significant risk factor for the severity of COVID-19. There was no significant association between the two variants and citrullinated histone (H3). Conclusion TLR2 rs5743708 and TLR9 rs5743836 variants have been significantly related to a higher risk and severity of COVID-19 infection but had no effect on thrombus formation.