Procalcitonin in cervicovaginal secretion in pregnancies complicated by preterm labor—a preliminary report

Value of maternal procalcitonin levels for predicting subclinical intra‐amniotic infection in preterm premature rupture of membranes

“…in the cervicovaginal secretions of preterm delivery patients. However, a relationship between cervicovaginal ProCT concentrations, and the beginning of active delivery and signs of infection was not identified . A subsequent study found higher maternal plasma ProCT levels in preterm delivery patients than in healthy control pregnant women …”

Are vaginal fluid procalcitonin levels useful for the prediction of subclinial infection in patients with preterm premature rupture of membranes?

“…In our own recent study PCT in cervicovaginal secretion of pregnant women with preterm labor and intact membranes was found. 12 However, no association was observed either between PCT concentration at the onset of preterm labor and laboratory signs of infection or between PCT concentration and time between admission to hospital and delivery.…”

“…Procalcitonin (PCT), a prohormone consisting of 116 amino acids, is recognized as a specific marker of generalized bacterial infections 8,9 . Although there is an increasing awareness of the usefulness of assessing PCT levels in clinical practice, there are only a few published data about PCT being evaluated during term and preterm parturition 10–12 . The source of PCT synthesis in the course of different diseases is not well understood.…”

“…8,9 Although there is an increasing awareness of the usefulness of assessing PCT levels in clinical practice, there are only a few published data about PCT being evaluated during term and preterm parturition. [10][11][12] The source of PCT synthesis in the course of different diseases is not well understood. However, it is known that parafolicular cells of the thyroid are not responsible for the production of PCT in disease states because the concentration of this prohormone also increases in patients after thyroid gland removal.…”

Maternal Plasma Procalcitonin Concentrations in Pregnancy Complicated by Preterm Premature Rupture of Membranes

“…In serum of healthy individuals, it is present at less than 0.5 ng/mL; but in conditions leading to systemic inflammatory response syndrome or sepsis, it rapidly increases to high levels [8–10]. Although PCT continues to be found increasingly useful in modern clinical practice, there are only a few published data on PCT in pregnancy [11–13]. In our own recent study, higher plasma PCT concentrations were found in preterm labor when compared to healthy pregnants [12].…”