Procalcitonina en sangre de cordón en la valoración del riesgo de sepsis neonatal precoz

Salguero, O. Oria de Rueda; Mosquera, José Beceiro; González, Marta Barrionuevo; M, Crespo; Soria, C

doi:10.1016/j.anpedi.2016.09.003

Cited by 3 publications

(3 citation statements)

References 33 publications

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“…Another study reported that serum PCT levels were negative in 88.23% and positive in 11.77% of patients. 12 In our study, higher results of positive sepsis screen are due to the higher proportion of preterm participants (35.22%), the higher percentage of high-risk PSS (>2) participants (37.66%), and various maternal factors such as poor nutrition, anemia, low maternal education, and low socioeconomic status. Other studies 7,13 report low positive sepsis screen, but these studies were done in developed countries having better socioeconomic status of families.…”

Section: Discussionmentioning

confidence: 48%

“…Serum PCT in group 2 participants concerning blood culture was also reported by other workers. [12][13][14][15] The higher value of PCTpositive newborns in positive PSS patients in our study is most probably due to the high number of preterm and low birth weight. Another study reported that serum PCT levels were negative in 88.23% and positive in 11.77% of patients.…”

Section: Discussionmentioning

confidence: 51%

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Diagnostic Accuracy of Cord and Venous Blood Procalcitonin in Relation to Neonatal Sepsis Screen

Meena

Sharma

Bagri

et al. 2022

Journal of Neonatology

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Background: Neonatal sepsis is an important cause of neonatal deaths globally. Diagnosis of neonatal sepsis is established based on the clinical status of the newborn and microbiological tests of sepsis screen. Mid-phase markers of inflammation such as C-reactive protein (CRP) and serum procalcitonin (PCT) are considered useful and sensitive for early diagnosis. Most of the studies evaluating serum cord blood PCT as a diagnostic marker for neonatal septicemia have been carried out in peripheral venous blood with smaller sample sizes with the inclusion of neonates without considering perinatal sepsis scores (PSSs). Objective: To compare the diagnostic accuracy of cord blood PCT with venous blood PCT, alone and as part of sepsis screening parameters. Study Design: This hospital-based, prospective diagnostic accuracy study aimed to evaluate the diagnostic accuracy of serum PCT alone and in combination with other diagnostic modalities for the detection of early-onset neonatal sepsis in cord blood and to compare the diagnostic utility of PCT with neonatal sepsis screening parameters in venous blood and was conducted at a tertiary care center. Categorical/nominal variables were expressed as numbers and percentages and were analyzed using the chi-square test. The receiver–operating characteristic curve was drawn to determine the area under the curve (with a 95% confidence interval) for various parameters for the diagnosis of sepsis. Sensitivity, specificity, positive-predictive value (PPV), negative-predictive value (NPV), and diagnostic accuracy were calculated by using a 2 × 2 contingency table. All statistical analyses were done using SPSS trial version 20. Participants: A total of 247 newborns delivered with positive PSSs were enrolled. Intervention: In neonates with a positive PSS, cord blood serum PCT, sepsis screen, and blood culture were sent at the time of birth. They were observed for 72 hours for signs and symptoms suggestive of sepsis. Results: Statistical analysis of cord blood serum PCT for detecting blood culture-positive patients showed that PCT has a sensitivity of 44.4%, specificity of 86.4%, PPV of 33.3%, and NPV of 91.1%. Overall diagnostic accuracy is 80.9% indicating that cord blood PCT is a good test for identifying these patients ( p <.05). However, venous blood PCT failed to demonstrate similar results. Conclusion: Umbilical blood sampling protects neonates from the pain of venipunctures. Statistical comparison of cord blood PCT in relation to sepsis screen and/or blood culture and comparisons with the venous blood parameters in the same domains suggests better sensitivity and specificity than venous blood PCT. This early serological biomarker is valuable for early diagnosis and management while awaiting blood culture reports and helps in reducing the separation of neonates with suspected sepsis from their mother and thus helping in developmental supportive care.

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Section: Discussionmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 51%

Diagnostic Accuracy of Cord and Venous Blood Procalcitonin in Relation to Neonatal Sepsis Screen

Meena

Sharma

Bagri

et al. 2022

Journal of Neonatology

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“…In the same time, use for more specific biomarkers is studied, as PCT dosed on cord blood [24,25]. Those complementary strategies might be additional tolls in the future, to enhance the clinical exam sensibility.…”

Section: Discussionmentioning

confidence: 99%

Term newborns at risk for early-onset neonatal sepsis: Clinical surveillance versus systematic paraclinical test

Schmitt¹,

Novy²,

Hascoët

2021

Archives de Pédiatrie

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IntroductionEarly onset neonatal sepsis is a rare but potentially lethal affection which is very often suspected. Previous national guidelines recommended the use of systematic paraclinic tests for healthy newborns with suspected infection. These guidelines have been updated in 2017 by the French Haute Autorité de Santé, and promote initial clinical monitoring taking into account the infectious risk level for term and near term born infants.Objectives: To assess the impact of the new recommendations on antibiotic therapy prescription and on the outcomes of infants born from 36 weeks gestation. Materials and methodsThis study compared the management and the outcome of neonates born from 36 weeks gestation in the level III University Hospital of Nancy, according to their infectious risk level during two periods, before and after the update of national recommendations: from July 1 st to December 31 st 2017, versus July 1 st to December 31 st 2018. Data were retrospectively first period, there were 18 newborns (1.4%) hospitalized for suspicion of infection versus 9 (0.8%) in the second (p = 0.13). The duration of hospitalization was 5.7+/-1.7 days in the first period versus 5.2 +/-3 days in the second (p = 0.33). ConclusionThe application of the new guidelines enables a reduction of antibiotic exposure without additional risk.

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Procalcitonin levels in maternal serum and cord blood as marker for diagnosis of early onset neonatal sepsis

Yadav

Agarwal

Rani

et al. 2023

European Journal of Obstetrics & Gynecology and Reproductiv

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Procalcitonina en sangre de cordón en la valoración del riesgo de sepsis neonatal precoz

Cited by 3 publications

References 33 publications

Diagnostic Accuracy of Cord and Venous Blood Procalcitonin in Relation to Neonatal Sepsis Screen

Diagnostic Accuracy of Cord and Venous Blood Procalcitonin in Relation to Neonatal Sepsis Screen

Term newborns at risk for early-onset neonatal sepsis: Clinical surveillance versus systematic paraclinical test

Procalcitonin levels in maternal serum and cord blood as marker for diagnosis of early onset neonatal sepsis

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