Procamine and other basic peptides in the venom of the honeybee (Apis mellifera)

Peck, M. Larry; O’Connor, Rod

doi:10.1021/jf60191a002

Cited by 22 publications

(3 citation statements)

References 16 publications

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“…At last, other peptides have been reported on BV. Procamines are small peptides of 5 aa residues; principally, there are procamine A and procamine B, both characterized by the presence of histamine in its C-terminal [101]. Minimine is a peptide of 48-52 aa residues and a molecular weight of 6000 Da, the biological activity of which is still unknown [102].…”

Section: Minor Peptidesmentioning

confidence: 99%

Bee Venom: An Updating Review of Its Bioactive Molecules and Its Health Applications

2020

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Bee venom (BV) is usually associated with pain since, when humans are stung by bees, local inflammation and even an allergic reaction can be produced. BV has been traditionally used in ancient medicine and in acupuncture. It consists of a mixture of substances, principally of proteins and peptides, including enzymes as well as other types of molecules in a very low concentration. Melittin and phospholipase A2 (PLA2) are the most abundant and studied compounds of BV. Literature of the main biological activities exerted by BV shows that most studies focuses on the comprehension and test of anti-inflammatory effects and its mechanisms of action. Other properties such as antioxidant, antimicrobial, neuroprotective or antitumor effects have also been assessed, both in vitro and in vivo. Moreover, human trials are necessary to confirm those clinical applications. However, notwithstanding the therapeutic potential of BV, there are certain problems regarding its safety and the possible appearance of adverse effects. On this perspective, new approaches have been developed to avoid these complications. This manuscript is aimed at reviewing the actual knowledge on BV components and its associated biological activities as well as the latest advances on this subject.

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Section: Minor Peptidesmentioning

confidence: 99%

Bee Venom: An Updating Review of Its Bioactive Molecules and Its Health Applications

2020

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“…Special emergency first aid kits (available by prescription) should be kept available (3). Sadly enough, the wives of many beekeepers seem unusually susceptible to venom allergy, possibly by the development of an inhalant sensitivity to the particulates adhering to the husband's working clothes (4).…”

Section: Physiological Activitiesmentioning

confidence: 99%

“…The experimental evidence is, however, generally considered sufficient to warrant even more intensive investigation of this possible "natural curative," Additional interest in potential therapeutic uses of bee venom has been stimulated by reports of venom components and synthetic analogs (5) that protect test animals against the affects of exposure to high energy radiation. One of the more promising uses of the pure venom is in the treatment of persons allergic to bee sting (4).…”

Section: Physiological Activitiesmentioning

confidence: 99%