“…This holistic and sustainable model contributes to the theory of implementation of Industry 4.0, presenting that (i) it is possible to migrate from any stage to Industry 4.0, but to reduce risk exposure and investments it is advisable that companies have at least adopted Automation and Information Technologies; (ii) Cleaner production should be considered a strategic factor to base the implementation process, not as a result of this process, bringing environmental and economic gains, furthermore increasing efficiency and reducing risks to environment and people [5,[8][9][10][11]; (iii) Government, unions, banks, academic institutions, other organizations and institutions, as well as private companies, should join efforts by collaborating with this implementation process [18,47,72], helping to develop sustainable processes, infrastructure and technologies to increase sustainable transformation of these companies towards Industry 4.0; (iv) Due to the risks, complexity and volume of investments, the implementation process must be led by top executives supported by technicians [82,84]; (v) Needs and goals must be defined from the beginning to guide investments and the course of actions [84]; (vi) The peculiarities of each company must be considered before establishing an implementation process; (vii) The model directly contributes to the Sustainable Development Goals 9-Industry, innovation and infrastructure, 12-Responsible consumption and production, and 15-Life on land and, indirectly, to some others.…”