Proceedings of the 11th Alcohol Hangover Research Group Meeting, in Nadi, Fiji

Palmer, Emily; Arnoldy, Lizanne; Ayre, Elizabeth; Benson, Sarah; Balikji, Stephanie; Bruce, Gillian; Fu, Chen; Pabst, Albertine van Lawick van E; Loo, Aurora J. A. E. van de; Rossum, C.J.I. Van; O’Neill, Sean; Scholey, Andrew; Terpstra, Chantal; Wijk, Michelle van; Verster, Joris C.

doi:10.3390/proceedings2020043001

Cited by 6 publications

(6 citation statements)

References 34 publications

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“…While GGT is a reliable biomarker of liver damage caused by chronic heavy drinking [ 65 , 66 , 67 ], previous research has indicated that GGT levels are not associated with AH susceptibility [ 49 ] and, consistent with the findings of this study, are not necessarily elevated during AH [ 39 ]. Although it was not demonstrated in the current study, compelling evidence indicates an impairing effect of AH on immune functioning, and more reliable markers of this may include, but are not limited to, interleukin (IL)-6, IL-10, IL-12 and tumor necrosis factor (TNF)-α [ 37 , 68 , 69 ].…”

Section: Discussionmentioning

confidence: 83%

Effects of Rapid Recovery on Alcohol Hangover Severity: A Double-Blind, Placebo-Controlled, Randomized, Balanced Crossover Trial

Scholey

Ayre

Stock

et al. 2020

JCM

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The aim of this study was to evaluate the efficacy of putative hangover treatment, Rapid Recovery, in mitigating alcohol hangover (AH) symptom severity. Using a double-blind, randomized, placebo-controlled, balanced crossover design, 20 participants attended the laboratory for two evenings of alcohol consumption, each followed by morning assessments of AH severity. Participants were administered Rapid Recovery and placebo on separate visits. In the first testing visit, participants self-administered alcoholic beverages of their choice, to a maximum of 1.3 g/kg alcohol. Drinking patterns were recorded and replicated in the second evening testing visit. In the morning visits, AH severity was assessed using questionnaires measuring AH symptom severity and sleep quality, computerized assessments of cognitive functioning as well as levels of blood biomarkers of liver function (gamma-glutamyl transferase (GGT)) and inflammation (high-sensitive C-reactive protein (hs-CRP)). There were no differences in the blood alcohol concentrations (BAC) obtained in the Rapid Recovery (mean = 0.096%) and placebo (mean = 0.097%) conditions. Participants reported significantly greater sleep problems in the Rapid Recovery compared to placebo condition, although this difference was no longer significant following Bonferroni’s correction. There were no other significant differences between Rapid Recovery and placebo. These data suggest that Rapid Recovery has no significant effect on alcohol hangover nor on associated biomarkers.

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Section: Discussionmentioning

confidence: 83%

Effects of Rapid Recovery on Alcohol Hangover Severity: A Double-Blind, Placebo-Controlled, Randomized, Balanced Crossover Trial

Scholey

Ayre

Stock

et al. 2020

JCM

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“…Van Wijk et al [20] examined hangover severity of n = 22 students who were on a skiing holiday in Italy. The students experienced multiple hangovers during this period.…”

Section: Day To Day Variability In the Presence And Severity Of Hangomentioning

confidence: 99%

The Assessment of Overall Hangover Severity

Verster

Loo

Benson

et al. 2020

JCM

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The aim of this study was to critically evaluate and compare the different methods to assess overall hangover severity. Currently, there are three multi-item hangover scales that are commonly used for this purpose. All of them comprise a number of hangover symptoms for which an average score is calculated. These scales were compared to a single, 1-item scale assessing overall hangover severity. The results showed that the hangover symptom scales significantly underestimate (subjective) hangover severity, as assessed with a 1-item overall hangover severity scale. A possible reason for this could be that overall hangover severity varies, depending on the frequency of occurrence of individual symptoms included in the respective scale. In contrast, it can be assumed that, when completing a 1-item overall hangover scale, the rating includes all possible hangover symptoms and their impact on cognitive and physical functioning and mood, thus better reflecting the actually experienced hangover severity. On the other hand, solely relying on hangover symptom scales may yield false positives in subjects who report not having a hangover. When the average symptom score is greater than zero, this may lead to non-hungover subjects being categorized as having a hangover, as many of the somatic and psychological hangover symptoms may also be experienced without consuming alcohol (e.g., having a headache). Taken together, the current analyses suggest that a 1-item overall hangover score is superior to hangover symptom scales in accurately assessing overall hangover severity. We therefore recommend using a 1-item overall hangover rating as primary endpoint in future hangover studies that aim to assess overall hangover severity. and naturalistic studies, in intervention studies examining treatment efficacy, and in survey research. Generally, they may be filled in by any drinker of all (adult) ages and in any drinking-related (research) context. There is, however, ongoing debate about which measure of hangover severity is most suitable. In this paper, we compare the three most widely used hangover symptom scales with a 1-item overall hangover severity rating, and discusses why the latter is a more reliable and useful measure to be included in future hangover research.

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“…Alcohol hangover is a complex phenomenon affecting biochemical, inflammatory and neurochemical mechanisms (Palmer et al 2019(Palmer et al , 2020. Generally, alcohol is considered to be the agent for causing hangover and related symptoms.…”

Section: Introductionmentioning

confidence: 99%

L-Cysteine Containing Vitamin Supplement Which Prevents or Alleviates Alcohol-related Hangover Symptoms: Nausea, Headache, Stress and Anxiety

Eriksson

Metsälä

Möykkynen

et al. 2020

Alcohol and Alcoholism

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Aims Alcohol-related hangover symptoms: nausea, headache, stress and anxiety cause globally considerable amount of health problems and economic losses. Many of these harmful effects are produced by alcohol and its metabolite, acetaldehyde, which also is a common ingredient in alcohol beverages. The aim of the present study is to investigate the effect of the amino acid L-cysteine on the alcohol/acetaldehyde related aftereffects. Methods Voluntary healthy participants were recruited through advertisements. Volunteers had to have experience of hangover and/or headache. The hangover study was randomized, double-blind and placebo-controlled. Nineteen males randomly swallowed placebo and L-cysteine tablets. The alcohol dose was 1.5 g/kg, which was consumed during 3 h. Results The primary results based on correlational analysis showed that L-cysteine prevents or alleviates hangover, nausea, headache, stress and anxiety. For hangover, nausea and headache the results were apparent with the L-cysteine dose of 1200 mg and for stress and anxiety already with the dose of 600 mg. Conclusions L-cysteine would reduce the need of drinking the next day with no or less hangover symptoms: nausea, headache, stress and anxiety. Altogether, these effects of L-cysteine are unique and seem to have a future in preventing or alleviating these harmful symptoms as well as reducing the risk of alcohol addiction.

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Proceedings of the 11th Alcohol Hangover Research Group Meeting, in Nadi, Fiji

Cited by 6 publications

References 34 publications

Effects of Rapid Recovery on Alcohol Hangover Severity: A Double-Blind, Placebo-Controlled, Randomized, Balanced Crossover Trial

Effects of Rapid Recovery on Alcohol Hangover Severity: A Double-Blind, Placebo-Controlled, Randomized, Balanced Crossover Trial

The Assessment of Overall Hangover Severity

L-Cysteine Containing Vitamin Supplement Which Prevents or Alleviates Alcohol-related Hangover Symptoms: Nausea, Headache, Stress and Anxiety

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