Proceedings of the Physiological Society, 21‐22 February 1986, Royal Free Meeting: Communications

doi:10.1113/jphysiol.1986.sp016171

The Journal of Physiology

1986

DOI: 10.1113/jphysiol.1986.sp016171

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Proceedings of the Physiological Society, 21‐22 February 1986, Royal Free Meeting: Communications

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Ionic dependence of amino-acid transport in the exocrine pancreatic epithelium: Calcium dependence of insulin action

Norman

Mann

1987

J. Membrain Biol.

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Rapid unidirectional transport (15 sec) of L-serine and 2-methylaminoisobutyric acid (MeAIB) was studied in the isolated perfused rat pancreas using a dual-tracer dilution technique. Time-course experiments in the presence of normal cation gradients revealed a time-dependent transstimulation of L-serine influx and transinhibition of MeAIB influx. Transport of the model nonmetabolized System A analog MeAIB was Na+ dependent and significantly inhibited during perfusion with 1 mM ouabain. Although transport of L-serine was largely Na+ independent, ouabain caused a time-dependent inhibition of transport. Influx of both amino acids appeared to be inhibited by the ionophore monensin but unaffected by a lowered extracellular potassium concentration. Removal of extracellular calcium had no effect on influx of the natural substrate L-serine, whereas stimulation of transport by exogenous insulin (100 microU/ml) was entirely dependent upon extracellular calcium and unaffected by ouabain. Paradoxically, exogenous insulin had no effect on the time-course of MeAIB influx. The characteristics of L-serine influx described in earlier studies together with our present findings suggest that insulin may modulate the activity of System asc in the exocrine pancreatic epithelium by a calcium-dependent mechanism.

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Ionic dependence of amino-acid transport in the exocrine pancreatic epithelium: Calcium dependence of insulin action

Norman

Mann

1987

J. Membrain Biol.

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Fasting and refeeding modulate neutral amino acid transport activity in the basolateral membrane of the rat exocrine pancreatic epithelium: fasting-induced insulin insensitivity

Mann

Muñoz²,

Peran³

1986

Biochimica et Biophysica Acta (BBA) - Biomembranes

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Proceedings of the Physiological Society, 21‐22 February 1986, Royal Free Meeting: Communications

Cited by 2 publications

References 18 publications

Ionic dependence of amino-acid transport in the exocrine pancreatic epithelium: Calcium dependence of insulin action

Ionic dependence of amino-acid transport in the exocrine pancreatic epithelium: Calcium dependence of insulin action

Fasting and refeeding modulate neutral amino acid transport activity in the basolateral membrane of the rat exocrine pancreatic epithelium: fasting-induced insulin insensitivity

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