Proceedings of the Second Annual Deep Brain Stimulation Think Tank: What's in the Pipeline

Gündüz, Ayşegül; Morita, Hokuto; Rossi, P. Justin; Allen, William; Alterman, Ron L.; Brontë‐Stewart, Helen; Butson, Christopher R.; Charles, David; Deckers, Sjaak; Hemptinne, Coralie de; Delong, Mahlon; Dougherty, Darin D.; Ellrich, Jens; Foote, Kelly D.; Giordano, James; Goodman, Wayne K.; Greenberg, Benjamin D.; Greene, David; Gross, Robert E.; Judy, Jack W.; Karst, Edward; Kent, Alexander R.; Kopell, Brian H.; Lang, Anthony E.; Lozano, Andrés M.; Lungu, Codrin; Lyons, Kelly E.; Machado, André G.; Martens, H.C.F.; Min, Hoon Ki; Ostrem, Jill L.; Pannu, Satinderpall S.; Ponce, Francisco A.; Pouratian, Nader; Reymers, Donnie; Schrock, Lauren E.; Sheth, Sameer A.; Shih, Ludy C.; Stanslaski, Scott; Steinke, G. Karl; Stypulkowski, Paul H.; Tröster, Alexander I.; Verhagen, Leo; Walker, Harrison C.; Okun, Michael S.

doi:10.3109/00207454.2014.999268

Cited by 17 publications

(18 citation statements)

References 78 publications

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“…This is a significant finding since PAC has become an important clinical measure for Parkinson's disease and has been proposed as a feedback signal for closed-loop DBS (Gunduz et al 2015). If the DBS stimulus artifact causes the PAC signature to be reduced without any therapeutic effect, it may not be a useful measure for patients undergoing DBS treatments, much less an appropriate closed-loop feedback signal.…”

Section: Discussionmentioning

confidence: 99%

“…The following analyses used PAC mapping as an example method to shed light on what cross-spectral measures can imply about interacting oscillations, as well as to reveal some of the common pitfalls in interpreting these results in biological signals. Since PAC has recently been suggested as a potential feedback signal for closed-loop brain stimulation (DBS) in Parkinson's disease (Gunduz et al 2015), particular attention was given to the neuronal firing changes that may lead to elevated PAC in parkinsonism and the dramatic PAC signal reduction (masking) induced by artifacts from periodic pulses similar to those used for clinically therapeutic DBS.…”

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confidence: 99%

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Phase-amplitude coupling, an indication of bursting in parkinsonism, is masked by periodic pulses

Sanders

2016

Journal of Neurophysiology

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Sanders TH. Phase-amplitude coupling, an indication of bursting in parkinsonism, is masked by periodic pulses. J Neurophysiol 115: 1587-1595, 2016. First published January 20, 2016 doi:10.1152/jn.00801.2015-Interactions between neural oscillations in the brain have been observed in many structures including the hippocampus, amygdala, motor cortex, and basal ganglia. In this study, one popular approach for quantifying oscillation interactions was considered: phase-amplitude coupling. The goals of the study were to use simulations to examine potential causes of elevated phase-amplitude coupling in parkinsonism, to compare simulated parkinsonian signals with recorded local field potentials from animal models of parkinsonism, to investigate possible relationships between increased bursting in parkinsonian single cells and elevated phase-amplitude coupling, and to uncover potential noise and artifact effects. First, a cell model that integrates incremental input currents and fires at realistic voltage thresholds was modified to allow control of stochastic parameters related to firing and burst rates. Next, the input currents and distribution of integration times were set to reproduce firing patterns consistent with those from parkinsonian subthalamic nucleus cells. Then, local field potentials were synthesized from the output of multiple simulated cells with varying degrees of synchronization and compared with subthalamic nucleus recordings from animal models of parkinsonism. The results showed that phase-amplitude coupling can provide important information about underlying neural activity. In particular, signals synthesized from synchronized bursting neurons showed increased oscillatory interactions similar to those observed in parkinsonian animals. Additionally, changes in bursting parameters such as the intraburst rate, the mean interburst period, and the amount of synchronization between neurons influenced the phase-amplitude coupling in predictable ways. Finally, simulation results revealed that small periodic signals can have a surprisingly large masking effect on phase-amplitude coupling.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Phase-amplitude coupling, an indication of bursting in parkinsonism, is masked by periodic pulses

Sanders

2016

Journal of Neurophysiology

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“…Advanced DBS systems such as those that rely on real-time feedback from electrophysiological signals, provide the first generation of implantable devices that identify symptomatic and healthy brain states (Gunduz et al, 2014). These devices include the Medtronic Activa PC+S (Ryapolova-Webb et al, 2014) and Neuroscan RNS (Sun et al, 2008).…”

Section: New Approaches For Bg-dbs Researchmentioning

confidence: 99%

“…These devices include the Medtronic Activa PC+S (Ryapolova-Webb et al, 2014) and Neuroscan RNS (Sun et al, 2008). With the understanding that changes in neuronal firing frequency occur in a pathogenic state, this approach shows potential in many disorders that are currently treated with DBS (Gunduz et al, 2014). Exaggerated beta band (8–35 Hz) synchrony in STN local field potentials occurs in PD patients, which is attenuated during therapeutic DBS, and returns when stimulation stops (Bronte-Stewart et al, 2009 Kuhn, 2008).…”

Section: New Approaches For Bg-dbs Researchmentioning

confidence: 99%

Toward sophisticated basal ganglia neuromodulation: Review on basal ganglia deep brain stimulation

Cunha

Boschen

Gómez-A

et al. 2015

Neuroscience & Biobehavioral Reviews

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This review presents state-of-the-art knowledge about the roles of the basal ganglia (BG) in action-selection, cognition, and motivation, and how this knowledge has been used to improve deep brain stimulation (DBS) treatment of neurological and psychiatric disorders. Such pathological conditions include Parkinson’s disease, Huntington’s disease, Tourette syndrome, depression, and obsessive-compulsive disorder. The first section presents evidence supporting current hypotheses of how the cortico-BG circuitry works to select motor and emotional actions, and how defects in this circuitry can cause symptoms of the BG diseases. Emphasis is given to the role of striatal dopamine on motor performance, motivated behaviors and learning of procedural memories. Next, the use of cutting-edge electrochemical techniques in animal and human studies of BG functioning under normal and disease conditions is discussed. Finally, functional neuroimaging studies are reviewed; these works have shown the relationship between cortico-BG structures activated during DBS and improvement of disease symptoms.

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“…23 Adoption of DBS by multidisciplinary teams responsible for the treatment of various neuropsychiatric disorders continues to increase, and the number of prospectively controlled trials for these disorders is also increasing.…”

Section: 21196mentioning

confidence: 99%

Deep brain stimulation for obesity: past, present, and future targets

Dupré¹,

Tomycz²,

Oh³

et al. 2015

FOC

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The authors review the history of deep brain stimulation (DBS) in patients for treating obesity, describe current DBS targets in the brain, and discuss potential DBS targets and nontraditional stimulation parameters that may improve the effectiveness of DBS for ameliorating obesity. Deep brain stimulation for treating obesity has been performed both in animals and in humans with intriguing preliminary results. The brain is an attractive target for addressing obesity because modulating brain activity may permit influencing both sides of the energy equation—caloric intake and energy expenditure.

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Proceedings of the Second Annual Deep Brain Stimulation Think Tank: What's in the Pipeline

Cited by 17 publications

References 78 publications

Phase-amplitude coupling, an indication of bursting in parkinsonism, is masked by periodic pulses

Phase-amplitude coupling, an indication of bursting in parkinsonism, is masked by periodic pulses

Toward sophisticated basal ganglia neuromodulation: Review on basal ganglia deep brain stimulation

Deep brain stimulation for obesity: past, present, and future targets

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