We propose a novel bio-sensor structure composed of double sided-wall Bragg gratings and dual-slot-micro-ring waveguides. The slot waveguide is a better choice to interact the bio-material under investigation with the propagating light with in the slot region. The incident light field propagates clockwise through the slot micro-ring resonator, the reflection light field propagates counterclockwise in the slot Bragg grating. By optimizing the geometric parameters of the device, the spectral response is tailored to obtain a sharp resonant peak simulated by the finite- difference time-domain (FDTD) method. The spectrum can be tuned not only by geometrically changing the couple distance in slot Bragg grating resonator, but also by dynamically altering the depth and number of the Bragg grating. Furthermore, the device is easy to yield an extinction ratio of 11 dB, a FWHM of 1.1 nm and a quality factor of [Formula: see text]. The device with a small footprint can enable integration with some photonic devices on a chip and have great promising for applications including tunable sensors, slow-light devices and optical communication.