Process Engineering and Mini‐Plant Technology

Strube, Jochen; Bäcker, W.; Schulte, Michael

doi:10.1002/9783527635122.ch5

Cited by 5 publications

(2 citation statements)

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“…However, the appropriate pre-treatment and solid-liquid extraction operations including the choice of the extraction agent have a major impact for the separation design, which is determined by yield and amount of side components. A detailed description of the authors' point of view is given in [8,59].…”

Section: Solid-liquid Extractionmentioning

confidence: 99%

“…Therefore, it is essential to quantify process' potential as a benchmark of the state of the art. Typical process schemes are shown as an example to exemplify the involved unit operations for the group of MABs [79,80] and phyto-extracts [7,8]. The data basis for this analysis is described by mass and energy balances of the whole process, which are calculated first in a process analysis with a flowsheet simulation tool like e.g.…”

Section: Process Analysismentioning

confidence: 99%

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Process Development and Design of Downstream Processes

Strube¹,

Grote²,

Josch³

et al. 2011

Chemie Ingenieur Technik

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State-of-the-art of process development, scale-up and design for downstream processes is described for complex mixtures in biotechnology. The focus is on fermentation broth and plant-based extracts to derive methodological arguments. Academic and industrial approaches are discussed with an assessment based on some process relevant criteria. Examples of monoclonal antibody, insulin and penicillin production processes are chosen to develop a sound argumentative basis.Demands of total process integration, accuracy and sensitivity of phenomena, resulting e.g. in miniaturization of laboratory experiments and linked with necessary in-depth modeling are developed and implemented. Specific tasks of unit operation are displayed and their integration into an efficient process sequence is demonstrated. Based on that, further research needs are pointed out and corresponding activities are identified. For instance, the transfer of well established methods in chemical engineering like process modeling in combination with laboratory scale experiments and final miniplant validation should be followed consequently also in biotechnology applications. Some drawbacks in academic education and industrial training as well as organizational structures are discussed to help address this issue.

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Section: Solid-liquid Extractionmentioning

confidence: 99%

Section: Process Analysismentioning

confidence: 99%