2018
DOI: 10.1080/08982112.2018.1539232
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Process optimization using sequential design of experiment: A case study

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Cited by 4 publications
(5 citation statements)
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“…If there is only one factor affecting the response, the one-way ANOVA and the multiple comparison methods, such as Tukey’ test and least significance difference method, are used to determine an appropriate level of a significant factor based on a desired criterion (maximization, minimization or desired target). Otherwise, the 2 k + center point and ANOVA will be used to investigate whether there is an evidence of curvature in the response over the region of exploration (Montgomery, 2005; Lee, 2019; Lv, 2019). If the curvature does not exist in the model, the experimenter needs to adjust the levels of each factor using the method of steepest ascent or steepest descent for the criterion of maximaization or minimization.…”
Section: Methodsmentioning
confidence: 99%
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“…If there is only one factor affecting the response, the one-way ANOVA and the multiple comparison methods, such as Tukey’ test and least significance difference method, are used to determine an appropriate level of a significant factor based on a desired criterion (maximization, minimization or desired target). Otherwise, the 2 k + center point and ANOVA will be used to investigate whether there is an evidence of curvature in the response over the region of exploration (Montgomery, 2005; Lee, 2019; Lv, 2019). If the curvature does not exist in the model, the experimenter needs to adjust the levels of each factor using the method of steepest ascent or steepest descent for the criterion of maximaization or minimization.…”
Section: Methodsmentioning
confidence: 99%
“…Coleman and Antony (2000) stated that many teachers could not present real case studies in a classroom because of a lack of practical experience with DOE. To overcome this issue, Lv et al (2019) presented a case study of the startup of an ethanol–water distillation column to provide a practical experience of sequential learning strategy in solving complex system with DOE. The practical experience with DOE provided students and engineers guidance and capability of complex problem-solving, enabling an effective use of DOE.…”
Section: Introductionmentioning
confidence: 99%
“…The use of PB designs as a screening experiment, followed by the sequential use of Complete, Central Composite or Central Composite Rotational designs, e.g., were successfully employed to develop and evaluate the properties of an oil-based emulsion gel, optimize the production of an enzyme by an actinomycete in submerged fermentation, and to develop a method of sterols and squalene extraction and determination in cyanobacteria (CÂMARA et al, 2020;FAGUNDES et al, 2021;PATEL et al, 2021). The initial use of FF designs, followed by the sequential use of CF and/or Central Composite designs, in turn, was used by Keijok et al (2019) to optimize a method used in the synthesis of metallic nanoparticles, by Gautério et al (2020) to maximize the production of an enzyme by a yeast-like fungus using a by-product of rice grain milling, and by Lv et al (2019) to optimize an ethanol-water distillation column. According to the authors, the results obtained in the initial screening designs were essential to, in an economical number of experiments, identify significant factors that were affecting the system's response.…”
Section: Sequential Experimentationmentioning
confidence: 99%
“…In many problems, the authors justify their approach to solve the problem, and use two out of three experimental phases, namely, screening/characterization [44] and screening/optimization [45]. A comprehensive example of the sequential learning process in the response surface methodology framework, including the optimization of multiple responses simultaneously, is presented by Lv et al [46].…”
Section: Doe's Principles and Experimentation Strategymentioning
confidence: 99%