Process-related risk of beryllium sensitization and disease in a copper-beryllium alloy facility

Abstract

Sensitization and CBD were associated with an area in which beryllium air levels exceeded 0.2 microg/m3, and not with areas where this level was rarely exceeded. Employees at this copper-beryllium alloy facility had similar prevalences of sensitization and CBD as workers at facilities with higher beryllium air levels.

Properties of High Performance Alloys for Electromechanical Connectors

“…Processing of beryllium-containing particles during production and manufacturing of beryllium containing metals can cause lung disease (Schuler, 2005). Be-free compositions are legislatively urged in the European Union recently.…”

An industrial risk: Beryllium

“…BeS gelişenlerin tüm maruz kalanlara oranı %0.8-12 arasındadır. 7 Daha sonra duyarlılığın KBH gelişiminde öncelik edip, granuloma olarak bilinen yangısal hasarları meydana getirerek yavaş ve ilerleyici bir solunum sistemi hastalığına dönüştüğü bildirilmektedir. 8 KBH'lıların tüm maruz kalan işçilere oranı %0.4-8 olup, duyarlı-lık gelişenlere (BeS) göre risk oranı daha düşüktür.…”

“…8 KBH'lıların tüm maruz kalan işçilere oranı %0.4-8 olup, duyarlı-lık gelişenlere (BeS) göre risk oranı daha düşüktür. 7 Böylece duyarlılık gelişiminin hastalığın oluşumu için gerektiği, fakat BeS'li bireylerin hepsinde KBH oluşmadığı tahmin edilebilir.…”

Sensitization and chronic beryllium disease at a primary manufacturing facility, part 3: exposure–response among short-term workers

“…Processes or jobs worked have been used as surrogates for quantitative exposures in many studies. Process-related risks have been identified in the absence of exposure-response (1)(2)(3)6), suggesting that predictive exposure factors do exist but may not have been adequately characterized. Possible explanations may include, among others: (i) quantification of airborne beryllium exposure using metrics that do not take into account biological relevance, rather than metrics that consider lung deposition (7)(8)(9), and (ii) inclusion of exposure periods not relevant to risk due to uncertainty regarding time of onset of BeS and CBD in cross-sectional epidemiologic studies.…”

“…The interval between initial exposure to beryllium and the development of BeS can be as short as three months with several studies detecting a higher prevalence of BeS among workers with one year or less of employment tenure (3,6,(12)(13)(14). The interval between initial exposure and the development of CBD is not well understood.…”