Processed Fruiting Bodies of Lentinus edodes as a Source of Biologically Active Polysaccharides

Ziaja‐Sołtys, Marta; Radzki, Wojciech; Nowak, Jakub; Topolska, Jolanta; Jabłońska‐Ryś, Ewa; Sławińska, Aneta; Skrzypczak, Katarzyna; Kuczumow, Andrzej; Bogucka‐Kocka, Anna

doi:10.3390/app10020470

Cited by 25 publications

(11 citation statements)

References 60 publications

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“…During the process of fermentation, the extracts of Ganoderma lucidum mostly composed of polysaccharides and have the ability to increase the abundance of Bifidobacteria ( Yamin et al, 2012 ); Zhang et al (2017) demonstrated that the Ganoderan is extracted from the Ganoderma sp. and having β-(1→3)-D-glucans with β-(1→6)-D-glucopyranosyl branches and the molecular weight is around 1.2 × 10 6 Da to 4.4 × 10 6 Da ( Üstün et al, 2018 ; Ziaja-Sołtys et al, 2020 ). Additionally, due to the daily supplementation of Ganoderma lucidum polysaccharide strain, the abundance of bacteria like Roseburia , Lachnospiraceae , and Lactobacillus with health benefits to host enhanced significantly ( Li et al, 2016 ).…”

Section: Active Metabolite From Mushroommentioning

confidence: 99%

Mushrooms as Potential Sources of Active Metabolites and Medicines

Bhambri¹,

Srivastava

Mahale

et al. 2022

Front. Microbiol.

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BackgroundMushrooms exist as an integral and vital component of the ecosystem and are very precious fungi. Mushrooms have been traditionally used in herbal medicines for many centuries.Scope and ApproachThere are a variety of medicinal mushrooms mentioned in the current work such as Agaricus, Amanita, Calocybe, Cantharellus, Cordyceps, Coprinus, Cortinarius, Ganoderma, Grifola, Huitlacoche, Hydnum, Lentinus, Morchella, Pleurotus, Rigidoporus, Tremella, Trametes sp., etc., which play a vital role in various diseases because of several metabolic components and nutritional values. Medicinal mushrooms can be identified morphologically on the basis of their size, color (white, black, yellow, brown, cream, pink and purple-brown, etc.), chemical reactions, consistency of the stalk and cap, mode of attachment of the gills to the stalk, and spore color and mass, and further identified at a molecular level by Internal Transcribed Spacer (ITS) regions of gene sequencing. There are also other methods that have recently begun to be used for the identification of mushrooms such as high-pressure liquid chromatography (HPLC), nuclear magnetic resonance spectroscopy (NMR), microscopy, thin-layer chromatography (TLC), DNA sequencing, gas chromatography-mass spectrometry (GC-MS), chemical finger printing, ultra-performance liquid chromatography (UPLC), fourier transform infrared spectroscopy (FTIR), liquid chromatography quadrupole time-of-flight mass spectrometry (LCMS-TOF) and high-performance thin-layer chromatography (HPTLC). Lately, the matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) technique is also used for the identification of fungi.Key Finding and ConclusionMedicinal mushrooms possess various biological activities like anti-oxidant, anti-cancer, anti-inflammatory, anti-aging, anti-tumor, anti-viral, anti-parasitic, anti-microbial, hepatoprotective, anti-HIV, anti-diabetic, and many others that will be mentioned in this article. This manuscript will provide future direction, action mechanisms, applications, and the recent collective information of medicinal mushrooms. In addition to many unknown metabolites and patented active metabolites are also included.

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Section: Active Metabolite From Mushroommentioning

confidence: 99%

Mushrooms as Potential Sources of Active Metabolites and Medicines

Bhambri¹,

Srivastava

Mahale

et al. 2022

Front. Microbiol.

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“…Its chemical structure consists of a β-1, 3 glucopyranoside main chain with β-1, 6 glucopyranoside branched chain [ 61 ]. This β-glucan structure of lentinan was shown to mediate anticancer effect in vitro and in vivo [ 62 ]. There is evidence to suggest that the structural conformation of lentinan is critical for its anticancer activity; Indeed, the triple-helix conformation of lentinan had a higher anticancer effect compared to its single flexible chain structure [ 63 ].…”

Section: Anticancer Effects Of Shiitake and Its Main Medicative Compounds/extractsmentioning

confidence: 99%

Combining the Anticancer and Immunomodulatory Effects of Astragalus and Shiitake as an Integrated Therapeutic Approach

et al. 2021

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Astragalus root (Huang Qi) and Shiitake mushrooms (Lentinus edodes) are both considered medicinal foods and are frequently used in traditional Chinese medicine due to their anticancer and immunomodulating properties. Here, the scientific literatures describing evidence for the anticancer and immunogenic properties of Shiitake and Astragalus were reviewed. Based on our experimental data, the potential to develop medicinal food with combined bioactivities was assessed using Shiitake mushrooms grown over Astragalus beds in a proprietary manufacturing process, as a novel cancer prevention approach. Notably, our data suggest that this new manufacturing process can result in transfer and increased bioavailability of Astragalus polysaccharides with therapeutic potential into edible Shiitake. Further research efforts are required to validate the therapeutic potential of this new Hengshan Astragalus Shiitake medicinal food.

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“…The antibacterial, antiviral, antioxidant, or antitumor effects of plant and fungal substances are widely known. Many of them are also used to treat human and animal gastrointestinal diseases caused by parasites [ 1 , 12 , 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Low-Molecular-Weight Secondary Metabolites from Fungi: Cerrena unicolor as a New Proposal of an Effective Preparation against Rhabditis Nematodes

et al. 2022

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Plants and fungi are known as a valuable source of natural medicines used in the treatment of various diseases. Many of them are used to treat human and animal gastrointestinal diseases caused by parasites. The aim of this study was to investigate for the first time the antinematode properties of extracellular low-molecular subfractions (ex-LMS) obtained from the liquid growth medium of idiophasic Cerrena unicolor cultures. The fungal fractions were isolated according to a procedure previously described by Jaszek et al. The in vitro tests were performed using nematodes of the Rhabditis genus. As demonstrated by the results, the total fraction with a molecular weight < 10 kDa (CU-A) and the 0.02–1.5 kDa fraction (CU-B) had nematicidal activity. It was found that the analyzed substances induced movement disturbances caused by the paralysis of the back part of the nematode’s body. The degree of body paralysis was proportional to the increase in the concentration of the tested fractions. Summarizing the obtained results in the context of the available literature data, it seems that C. unicolor may be a good new candidate for research on nematode infections.

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Processed Fruiting Bodies of Lentinus edodes as a Source of Biologically Active Polysaccharides

Cited by 25 publications

References 60 publications

Mushrooms as Potential Sources of Active Metabolites and Medicines

Mushrooms as Potential Sources of Active Metabolites and Medicines

Combining the Anticancer and Immunomodulatory Effects of Astragalus and Shiitake as an Integrated Therapeutic Approach

Low-Molecular-Weight Secondary Metabolites from Fungi: Cerrena unicolor as a New Proposal of an Effective Preparation against Rhabditis Nematodes

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