Processed Meat Intake and Bladder Cancer Risk in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cohort

Xu, Xin

doi:10.1158/1055-9965.epi-19-0604

Cited by 16 publications

(13 citation statements)

References 25 publications

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“…After excluding 7 deaths prior to completion of the DHQ, 16 cases without the completion date of the DHQ, 3,039 cases skipping ≥8 food frequency questions and 2,179 cases of extreme energy intake, there were 106,435 participants completing the eligible DHQ. Finally 92,984 cases were included into the analytical dataset after excluding 4,354 deaths or cancer cases diagnosed prior to the date of DHQ and 9,097 cases of missing necessary covariates (alcohol intake, smoking status, pack-years of smoking, body mass index (BMI), education, diabetes history, and family history of lung cancer) (13). The flow diagram describing the population selection process was listed in Figure 1A.…”

Section: Study Populationmentioning

confidence: 99%

Association between dietary sodium, potassium intake and lung cancer risk: evidence from the prostate, lung, colorectal and ovarian cancer screening trial and the Women’s Health Initiative

You¹,

Zhang²,

He³

et al. 2021

Transl Lung Cancer Res

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Background: Epidemiological studies have reported that dietary mineral intake plays an important role on lung cancer risk, but the association of sodium, potassium intake is still unclear. Methods:We determined the association between dietary sodium, potassium intake and lung cancer risk based on the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial and the Women's Health Initiative (WHI). Totally 165,409 participants who completed the baseline questionnaire (BQ) and diet history questionnaire (DHQ) were included into the analytical dataset, including 92,984 (44,959 men and 48,025 women) from the PLCO trial and 72,425 (women only) from the WHI cohort. Multivariable Cox proportional hazards regression was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) of incident lung cancer associated with dietary potassium and sodium intake. The dose-response relationship was also described using the spline smoothed curve after adjusting covariates.Results: After the median follow-up of 8.55 and 18.56 years, 1,278 and 1,631 new cases of lung cancer were identified in the PLCO trial and WHI cohort, respectively. Intake of sodium was significantly associated with the incidence of lung cancer in the PLCO trial after multivariate adjustment for men (HR: 1.19, 95% CI: 1.05-1.35; P for linear trend =0.044). There was a suggestion that lung cancer risk had a quadratic curve correlation with the increase of potassium intake for women (third vs. lowest quintile: HR: 0.72, 95% CI: 0.54-0.96; P for quadratic trend =0.042). The similar results showing an inverse association between potassium intake and lung cancer risk were also observed in the WHI cohort for women (highest vs. lowest quintile: HR: 0.82, 95% CI: 0.70-0.97; P for linear trend =0.009).Conclusions: Appropriate intake of potassium has a protective effect against lung cancer, while high consumption of sodium is associated with an increased risk of lung cancer.

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Section: Study Populationmentioning

confidence: 99%

Association between dietary sodium, potassium intake and lung cancer risk: evidence from the prostate, lung, colorectal and ovarian cancer screening trial and the Women’s Health Initiative

You¹,

Zhang²,

He³

et al. 2021

Transl Lung Cancer Res

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“…A small proportion (5-6%) of bladder cancers arise from occupational exposure [ 4 ]. Less-established risk factors for bladder cancers include diabetes [ 5 ], lack of physical activity [ 6 ], obesity [ 7 ], nulliparity [ 8 ] and high consumption of processed red meat [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Association of dietary tomato intake with bladder cancer risk in a prospective cohort of 101,683 individuals with 12.5 years of follow-up

Xie

et al. 2021

Aging

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Previous studies have provided limited evidence for the effect of tomato intake on bladder cancer incidence. This study aimed to evaluate the association between dietary tomato or lycopene consumption and bladder cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) Screening study. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression model adjusting for confounders. After a median of 12.5 years of follow-up, 774 incident bladder cancer cases were identified. We found no statistically significant association between dietary intake of raw tomatoes and bladder cancer risk (Adjusted model: HR Q5 VS Q1 = 1.20, 95% CI: 0.95-1.52; P for trend = 0.243). Dietary intakes of tomato catsup, tomato salsa and tomato juice were also not associated with the risk of bladder cancer (all P for trend > 0.05). There was no statistically significant association between dietary consumption of lycopene and bladder cancer risk (Adjusted model: HR Q5 vs. Q1 = 1.04, 95% CI 0.82-1.33; P for trend = 0.590). In summary, analysis of the PLCO study suggested that dietary consumption of tomato or lycopene was not associated with the risk of bladder cancer.

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“…However, this association with red meat consumption could only be observed among case‐control studies. More recently, this association was confirmed by a cohort study 41 . The effect of meat consumption may be explained by the carcinogenic compounds that are produced during the cooking and processing of meat, which includes nitrate, nitrite, heterocyclic amines and polycyclic aromatic hydrocarbons.…”

Section: Discussionmentioning

confidence: 78%

“…More recently, this association was confirmed by a cohort study. 41 The effect of meat consumption may be explained by the carcinogenic compounds that are produced during the cooking and processing of meat, which includes nitrate, nitrite, heterocyclic amines and polycyclic aromatic hydrocarbons. Since these compounds are excreted in the urine, they come in close contact with the inner lining of the bladder wall which may exert a carcinogenic effect on urothelial cells.…”

Section: Baseline Characteristicsmentioning

confidence: 99%

Adherence to a Western dietary pattern and risk of bladder cancer: A pooled analysis of 13 cohort studies of the Bladder Cancer Epidemiology and Nutritional Determinants international study

Dianatinasab

Wesselius

Salehi‐Abargouei

et al. 2020

Intl Journal of Cancer

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Little is known about the association of diet with risk of bladder cancer. This might be due to the fact that the majority of studies have focused on single food items, rather than dietary patterns, which may better capture any influence of diet on bladder cancer risk. We aimed to investigate the association between a measure of Western dietary pattern and bladder cancer risk. Associations between adherence to a Western dietary pattern and risk of developing bladder cancer were assessed by pooling data from 13 prospective cohort studies in the "BLadder cancer Epidemiology and Nutritional Determinants" (BLEND) study and applying Cox regression analysis. Dietary data from 580 768 study participants, including 3401 incident cases, and 577 367 noncases were analyzed. A direct and significant association was observed between higher adherence to a Western dietary pattern and risk of bladder cancer (hazard ratio (HR) comparing highest with lowest tertile scores: 1.54, 95% confidence interval (CI): 1.37, 1.72; P-trend = .001). This association was observed for men (HR comparing highest with lowest tertile scores: 1.72; 95% CI: 1.51, 1.96; P-trend = .001), but not women (P-het = .001). Results were consistent with HR above 1.00 after stratification on cancer subtypes (nonmuscle-invasive and muscle-invasive bladder cancer). We found evidence that adherence to a Western dietary pattern is associated with an increased risk of bladder cancer for men but not women.

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Processed Meat Intake and Bladder Cancer Risk in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cohort

Cited by 16 publications

References 25 publications

Association between dietary sodium, potassium intake and lung cancer risk: evidence from the prostate, lung, colorectal and ovarian cancer screening trial and the Women’s Health Initiative

Association between dietary sodium, potassium intake and lung cancer risk: evidence from the prostate, lung, colorectal and ovarian cancer screening trial and the Women’s Health Initiative

Association of dietary tomato intake with bladder cancer risk in a prospective cohort of 101,683 individuals with 12.5 years of follow-up

Adherence to a Western dietary pattern and risk of bladder cancer: A pooled analysis of 13 cohort studies of the Bladder Cancer Epidemiology and Nutritional Determinants international study

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