The carotid plaque prevalence increased significantly with increasing age. However, significant stenosis only increases slightly with age. Pujia and colleagues found in their study that all flow-reducing lesions (lumen reduction >50%) were found in the age group 75-94 years [6].
Risk factors for carotid stenosis in elderly patientsThere is no evidence of a significant difference in the risk factors for atherosclerosis in the elderly compared with other age groups, including gender, hypertension, diabetes mellitus, smoking, renal impairment and hypercholesterolemia [7]. Nevertheless, there seem to be certain metabolic and inflammatory risk factors that are of importance in the development of the carotid arteries in the elderly population.
Inflammatory risk factorInflammation may play a key role in the pathogenesis of atherosclerosis. A study of 5417 participants over 65 years of age conducted by Cao and colleagues found that the elevation of C-reactive protein, an important inflammatory marker, is correlated with a higher future occurrence of ischemic stroke in this cohort [8]. This was however, largely independent of atherosclerosis severity as measured by the carotid intima-media thickness (IMT). There seems to be some supportive evidence that the association of C-reactive protein and stroke might be stronger in men than in women [8]. However, further research is required in this area.Stroke remains one of the leading causes of death in western countries and puts a large burden on healthcare budgets [1,2]. Atherosclerotic disease at the carotid bifurcation is responsible for approximately 20-25% of all strokes incidents [3]. Although it is well known that carotid artery disease incidence increases with age, the accurate incidence and survival in very old patients remains limited [3]. As the population is growing older, this information is of the utmost i mportance, p articularly for healthcare planners [4].This article aims to review the incidence, clinical presentation, diagnostic options and treatment modalities available for this significant group of patients based on the current available evidence.
Prevalence of carotid disease in elderly patientsThe Rotterdam study was one of the largest population-based studies in The Netherlands to confirm the increased incidence of stroke with increasing age, with a peak incidence occurrence at the age of 75-79 years, declining by 85 years of age and beyond. The study also demonstrated a slight increase in incidence among women [3].In addition, Avendano and colleagues studied the effect of socioeconomic status on stroke incidence among the elderly population. They found rather interesting results, whereby patients at the age of 65-74 years, with a lower education and/or income, had a higher stroke incidence of stroke. Patients of 75 years and older with a higher socioeconomic status, however, had higher stroke rates even after adjustment for other risk factors [5].Stroke is one of the leading causes of death in western countries and puts a large burden on healthcare budg...