Processing and surface modification of polymer nanofibers for biological scaffolds: a review

Abstract

This review discusses existing and emerging polymeric nanofiber fabrication techniques, fiber surface modification via post-processing, and their combined effects on cell adhesion, proliferation, and migration.

Engineered membranes for residual cell trapping on microfluidic blood plasma separation systems. A comparison between porous and nanofibrous membranes

“…Several approaches have been investigated in order to enhance the wettability of PLA-based porous or fibrous membranes in both dry and wet chemistry [29][30][31]. In this work, an aminolysis surface treatment via hexamethylenediamine (HDMA) was carried out.…”

“…Recently, we have shown that PLA can be used as a novel substrates for microfluidic devices [28]. During the last decades, researchers have contributed to widening the application range of PLA through chemical and physical alterations to the bulk and/or surface by introducing hydrophilic and biocompatible moieties [29,30]. Several modifications strategies such as plasma [31] or chemical [29] treatments have been employed to enable specific surface properties on PLA.…”

Optimization of ZnO Nanorods Growth on Polyetheresulfone Electrospun Mats to Promote Antibacterial Properties

“…Scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS) provide morphological and compositional analysis of PES/ZnO mats while thermogravimetric analysis (TGA) is useful to assess the best process conditions to guarantee the higher amount of ZnO with respect to PES scaffold. Biocidal action is associated to Zn 2+ ion leaching in solution, easily indicated by UV-Vis measurement of metallation of free porphyrin layers deposited on glass.A wide selection of polymers can be used to produce fibrous scaffolds and surface functionalization or material doping tailor their composition for specific applications, spanning from biomedicine to environmental remediation [3][4][5][6][7]. In this perspective, polymeric nanofibers are often combined with other classes of materials-i.e., inorganic nanostructures and/or organic molecules-to achieve specific deliverable highlights.…”

“…A wide selection of polymers can be used to produce fibrous scaffolds and surface functionalization or material doping tailor their composition for specific applications, spanning from biomedicine to environmental remediation [3][4][5][6][7]. In this perspective, polymeric nanofibers are often combined with other classes of materials-i.e., inorganic nanostructures and/or organic molecules-to achieve specific deliverable highlights.…”

Direct UV-Triggered Thiol–ene Cross-Linking of Electrospun Polyester Fibers from Unsaturated Poly(macrolactone)s and Their Drug Loading by Solvent Swelling

“…22 Currently there is a demand for next generation biopolymers for electrospinning that offer additional functionality for immobilizing bioactive cues or cross-linking to enable post-spinning manipulation such as drug loading. While fiber functionalization via click-chemistry has been explored and reviewed, 23,24 only a few examples of in-situ crosslinked electrospun fibers have been disclosed to date. In one example, Ellison reported a process in which a mixture of thioland ene-functional monomers was spun and simultaneously UV-crosslinked.…”