Processing, annealing and sterilisation of poly-l-lactide

Weir, N.A.; Buchanan, Fraser; Orr, John; Farrar, David; Boyd, Andrew J.

doi:10.1016/j.biomaterials.2003.10.076

Cited by 155 publications

(124 citation statements)

References 47 publications

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“…The data from this study were slightly higher than the literature values. The literature value of T m for PLA varied from 149 to 192°C [4][5][6][7][8][9][10][11].…”

Section: Results and Discussion 31 Membrane Characterizationmentioning

confidence: 99%

Gas Transport Properties and Crystalline Structures of Poly(lactic acid) Membranes

Sawada

Takahashi

Miyata

et al. 2010

Trans. Mat. Res. Soc. Japan

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Gas transport properties (i.e., permeability, diffusivity, and solubility) and the crystallinity/crystalline structure of poly(lactic acid) (PLA) membranes were systematically investigated. PLA membranes with different crystalline structures were prepared by regulating the heating and cooling conditions during their membrane preparation. The PLA membrane that was thermally-treated at 70°C was amorphous, while the membrane heated at higher than 80°C had crystalline structures. As the treatment temperature increased, the crystallinity increased and the PLA crystal growth branched out in a radial fashion. Regardless of crystallinity, the order of the gas permeability, diffusion, and solubility coefficients was the same for all membranes; permeability coefficient: H 2 >CO 2 >O 2 >N 2 >CH 4 ; diffusion coefficient: H 2 >O 2 >N 2 >CO 2 >CH 4 ; solubility coefficient: CO 2 >CH 4 >O 2 >N 2 >H 2 . Interestingly, unlike common crystalline polymer membranes, the permeability coefficient in a crystalline PLA membrane was larger than that in an amorphous PLA membrane. The gas permselectivity in the amorphous and crystalline PLA membranes was larger than 120 for H 2 /N 2 , 6 for O 2 /N 2 , 23 for CO 2 /N 2 , and 27 for CO 2 /CH 4 and less than 1 for CH 4 /N 2 .

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“…The data from this study were slightly higher than the literature values. The literature value of T m for PLA varied from 149 to 192°C [4][5][6][7][8][9][10][11].…”

Section: Results and Discussion 31 Membrane Characterizationmentioning

confidence: 99%

Gas Transport Properties and Crystalline Structures of Poly(lactic acid) Membranes

Sawada

Takahashi

Miyata

et al. 2010

Trans. Mat. Res. Soc. Japan

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“…Poisson's ratio, 12 , is assumed to be purely elastic. The major Poisson's ratios of wood fiber and matrix are f12 and m .…”

Section: Micromechanical Modelmentioning

confidence: 99%

Dynamic–Mechanical Properties of Wood–Fiber Reinforced Polylactide: Experimental Characterization and Micromechanical Modeling

Bogren

Gamstedt

Neagu³

et al. 2006

Journal of Thermoplastic Composite Materials

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Wood-fiber reinforced polylactide is a biodegradable composite where both fibers and matrix are from renewable resources. When designing new materials of this kind, it is useful to measure the influence of fiber-matrix interface properties on macroscopic mechanical properties.In particular, a quantitative measure of the dynamic stress transfer between the fibers and the matrix when the material is subjected to cyclic loading would simplify the development of wood-fiber composites. This is obtained by comparing the mechanical dissipation of the composite with a value predicted by a viscoelastic micromechanical model based on perfect interfacial stress transfer.The loss factors predicted by the model are 0.12 and 0.16 at dry and humid conditions, respectively, which amount to 63 and 66% of the experimentally determined values. For Young's moduli the predicted values are 1.01 and 0.88 GPa, which correspond to 92% of the experimentally determined values. The mismatch between the predicted and experimental values may be attributed to imperfect interfaces with restrained stress transfer.Loss factors are also determined for specific molecular bonds using dynamic Fourier transform infrared (FT-IR) spectroscopy. These values show the same trends with regard to moisture content as the macroscopically determined loss factors.

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“…The microdevices used in this study are fabricated using poly-L-lactic acid (PLLA) with a molecular weight of 217 kDa from SurModics Inc (Eden Prairie, MN, USA). PLLA is known to degrade via bulk degradation where water is first absorbed, followed by swelling of the material before the material loses its integrity and disintegrates [17]. Visual observations upon microdevice explantation after the treatment period showed that there was no swelling of the material.…”

Section: Microdevice Design and Fabricationmentioning

confidence: 99%

Sustained, low-dose intraperitoneal cisplatin improves treatment outcome in ovarian cancer mouse models

Tanenbaum

et al. 2015

Journal of Controlled Release

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Intraperitoneal (IP) chemotherapy for ovarian cancer treatment prolongs overall survival by 16 months compared to intravenous chemotherapy but is not widely practiced due to catheter-related complications and complexity of administration. An implantable, nonresorbable IP microdevice was used to release chemotherapeutic agent at a constant rate of approximately 1.3 µg/hour in vitro and 1.0 µg/hour in vivo. Studies conducted in two orthotopic murine models bearing human xenografts (SKOV3 and UCI101) demonstrate that continuous dosing reduces tumor burden to the same extent as weekly IP bolus drug injections. Treatment-induced toxicity was quantified via body weight loss and complete blood count. The microdevice resulted in significantly less toxicity than IP bolus injections, despite administration of higher cumulative doses (total area under the concentration-time curve of 3,049 ng-day/mL with the microdevice vs. 2,118 ng-day/mL with IP bolus injections). This preclinical study supports the concept that reduced toxicity with similar efficacy outcomes can be achieved by continuous dosing in ovarian cancer patients currently treated with IP therapy.

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Processing, annealing and sterilisation of poly-l-lactide

Cited by 155 publications

References 47 publications

Gas Transport Properties and Crystalline Structures of Poly(lactic acid) Membranes

Gas Transport Properties and Crystalline Structures of Poly(lactic acid) Membranes

Dynamic–Mechanical Properties of Wood–Fiber Reinforced Polylactide: Experimental Characterization and Micromechanical Modeling

Sustained, low-dose intraperitoneal cisplatin improves treatment outcome in ovarian cancer mouse models

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