Processing of environmental sounds in schizophrenic patients: disordered recognition and lack of semantic specificity

Tüscher, Oliver; Silbersweig, David; Pan, Hong; Smith, Thomas E.; Beutel, Manfred E.; Zonana, J.; Erbesh, V.; Weisholtz, Daniel S.; Stern, Emily; Engelien, Almut

doi:10.1016/j.schres.2004.06.010

Cited by 11 publications

(12 citation statements)

References 31 publications

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“…The individual rating of faces and sounds following the EEG paradigm also did not reveal any group differences, indicating that perception and subjective experience of sounds and faces were not impaired in our schizophrenia group—a finding that is in line with some previous reports (Tüscher et al , 2005; Lynn and Salisbury, 2008; Wynn et al , 2008). Nevertheless, it contradicts results of other studies of emotional face and prosody perception (Bozikas et al , 2006; Turetsky et al , 2007; Bach et al , 2009a; Kohler et al , 2010; Leitman et al , 2010).…”

Section: Discussionsupporting

confidence: 92%

“…Again, our study was different in that we did not calculate objective accuracy scores. Tüscher et al (2005) also did not find any differences in the valence and arousal ratings of emotional environmental sounds between patients and controls indicating that, in contrast to prosody, perception of environmental and human sounds seems to be preserved in schizophrenia.…”

Section: Discussionmentioning

confidence: 69%

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Modulation of affective face processing deficits in Schizophrenia by congruent emotional sounds

Müller

Kellermann

Seligman

et al. 2012

Soc Cogn Affect Neurosci

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Schizophrenia is a psychiatric disorder resulting in prominent impairments in social functioning. Thus, clinical research has focused on underlying deficits of emotion processing and their linkage to specific symptoms and neurobiological dysfunctions. Although there is substantial research investigating impairments in unimodal affect recognition, studies in schizophrenia exploring crossmodal emotion processing are rare. Therefore, event-related potentials were measured in 15 patients with schizophrenia and 15 healthy controls while rating the expression of happy, fearful and neutral faces and concurrently being distracted by emotional or neutral sounds. Compared with controls, patients with schizophrenia revealed significantly decreased P1 and increased P2 amplitudes in response to all faces, independent of emotion or concurrent sound. Analyzing these effects with regard to audiovisual (in)congruence revealed that P1 amplitudes in patients were only reduced in response to emotionally incongruent stimulus pairs, whereas similar amplitudes between groups could be observed for congruent conditions. Correlation analyses revealed a significant negative correlation between general symptom severity (Brief Psychiatric Rating Scale-V4) and P1 amplitudes in response to congruent audiovisual stimulus pairs. These results indicate that early visual processing deficits in schizophrenia are apparent during emotion processing but, depending on symptom severity, these deficits can be restored by presenting concurrent emotionally congruent sounds.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 69%

Modulation of affective face processing deficits in Schizophrenia by congruent emotional sounds

Müller

Kellermann

Seligman

et al. 2012

Soc Cogn Affect Neurosci

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“…As far as the emotional valences are concerned, the evaluation of positive valence (“pleasant”) did not differ between groups, in line with a previous study using a broad range of non-verbal environmental sounds [48]. This result also indicates that patients with schizophrenia did not over-evaluate all the perceptual dimensions during the listening test and consequently is a supplementary argument for the validity of the proposed on-line sound evaluation.…”

Section: Discussionsupporting

confidence: 86%

On the correlation between perceptual inundation caused by realistic immersive environmental auditory scenes and the sensory gating inventory in schizophrenia

et al. 2015

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“…A hyperassociative hippocampal memory system can give rise to inappropriate associations, distorted perception, irrational expectations, and even hallucinations (Behrendt, 2010). In agreement with this perspective, patients with schizophrenia display excessive associations (Miller, 1989; Wentura et al, 2008; Manschreck et al, 2012), increased interference (Westerhausen et al, 2011), reduced cognitive flexibility (Elliott et al, 1998), and autonoetic awareness (Danion et al, 1999), lack of semantic specificity (Tüscher et al, 2005), difficulties to represent expected reward value (Gold et al, 2012), and deficits in emotional discrimination (Schneider et al, 2006). …”

Section: Discussionmentioning

confidence: 82%

MK-801 Impairs Cognitive Coordination on a Rotating Arena (Carousel) and Contextual Specificity of Hippocampal Immediate-Early Gene Expression in a Rat Model of Psychosis

Kubík¹,

Buchtová

Valeš

et al. 2014

Front. Behav. Neurosci.

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Flexible behavior in dynamic, real-world environments requires more than static spatial learning and memory. Discordant and unstable cues must be organized in coherent subsets to give rise to meaningful spatial representations. We model this form of cognitive coordination on a rotating arena – Carousel where arena- and room-bound spatial cues are dissociated. Hippocampal neuronal ensemble activity can repeatedly switch between multiple representations of such an environment. Injection of tetrodotoxin into one hippocampus prevents cognitive coordination during avoidance of a stationary room-defined place on the Carousel and increases coactivity of previously unrelated neurons in the uninjected hippocampus. Place avoidance on the Carousel is impaired after systemic administration of non-competitive NMDAr blockers (MK-801) used to model schizophrenia in animals and people. We tested if this effect is due to cognitive disorganization or other effect of NMDAr antagonism such as hyperlocomotion, spatial memory impairment, or general learning deficit. We also examined if the same dose of MK-801 alters patterns of immediate-early gene (IEG) expression in the hippocampus. IEG expression is triggered in neuronal nuclei in a context-specific manner after behavioral exploration and it is used to map activity in neuronal populations. IEG expression is critical for maintenance of synaptic plasticity and memory consolidation. We show that the same dose of MK-801 that impairs spatial coordination of rats on the Carousel also eliminates contextual specificity of IEG expression in hippocampal CA1 ensembles. This effect is due to increased similarity between ensembles activated in different environments, consistent with the idea that it is caused by increased coactivity between neurons, which did not previously fire together. Our data support the proposition of the Hypersynchrony theory that cognitive disorganization in psychosis is due to increased coactivity between unrelated neurons.

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Processing of environmental sounds in schizophrenic patients: disordered recognition and lack of semantic specificity

Cited by 11 publications

References 31 publications

Modulation of affective face processing deficits in Schizophrenia by congruent emotional sounds

Modulation of affective face processing deficits in Schizophrenia by congruent emotional sounds

On the correlation between perceptual inundation caused by realistic immersive environmental auditory scenes and the sensory gating inventory in schizophrenia

MK-801 Impairs Cognitive Coordination on a Rotating Arena (Carousel) and Contextual Specificity of Hippocampal Immediate-Early Gene Expression in a Rat Model of Psychosis

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