Processing of polymer nanofibers through electrospinning as drug delivery systems

Kenawy, El‐Refaie; Abdel-Hay, F. I.; El‐Newehy, Mohamed H.; Wnek, Gary E.

doi:10.1016/j.matchemphys.2008.07.081

Cited by 246 publications

(144 citation statements)

References 35 publications

Supporting

Mentioning

140

Contrasting

Order By: Relevance

“…[1][2][3][4][5] As the nanotechnology has been developed during the decades with several historical breakthroughs, [6][7][8][9][10][11] numerous new applications have been applied to DDSs. [12][13][14] Nanoparticles and nanobers have been widely used in DDSs due to their popular and simple production methods. Drug delivery system characteristics are improved with the incorporation of biodegradable polymer carriers which sustain the release of encapsulated drugs and reduce the side effects.…”

Section: Introductionmentioning

confidence: 99%

Improved shellac mediated nanoscale application drug release effect in a gastric-site drug delivery system

Qiu

et al. 2017

RSC Adv.

View full text Add to dashboard Cite

The development of biocompatible nanocomposites for biomedical applications such as drug release has attracted increasing attention in recent years. Shellac/sodium shellac nanofibers and nanoparticles were produced for drug delivery applications. Ketoprofen was loaded on the drug delivery system (DDS), and three schemes based on shellac/sodium shellac were chosen. The biocompatibility and nontoxicity of shellac and the promising results of the nanofibers and nanoparticles highlighted their challenging potential for controlled drug delivery applications. A significant increase of drug release rate can be observed at the gastric site. The prepared drug-loaded nanofibers and nanoparticles were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The results show that the above-mentioned drug delivery system is able to support high-efficiency encapsulation. A new drug delivery system was designed and studied through shellac and sodium shellac. The application scope of shellac to DDSs is extended.

show abstract

Section: Introductionmentioning

confidence: 99%

Improved shellac mediated nanoscale application drug release effect in a gastric-site drug delivery system

Qiu

et al. 2017

RSC Adv.

View full text Add to dashboard Cite

show abstract

“…4 Drug delivery systems using nanofibers are able to improve therapeutic efficacy, reduce toxicity, and enhance compliance of the patients by delivering drugs at a controlled rate over a period of time to the site of action. 5 Various biodegradable and biocompatible polymeric materials have been electrospun into nanoscale fibers and have been demonstrated for their potential as effective carriers for drug delivery. 6 Controlled drug delivery of tetracycline hydrochloride based on the fibrous delivery matrices of poly ethylene-co-vinyl acetate, polylactic acid and their blend have been developed.…”

Section: Introductionmentioning

confidence: 99%

Herbal drug incorporated antibacterial nanofibrous mat fabricated by electrospinning: An excellent matrix for wound dressings

Suganya

Ram

Lakshmi

et al. 2011

J of Applied Polymer Sci

155

View full text Add to dashboard Cite

Nano-components and nano-systems for health care and medical applications are the focus of many research projects worldwide. Nanofibrous membranes are highly soft materials with high surface-to-volume ratios, and therefore can serve as excellent carriers for therapeutic agents that are antibacterial or accelerate wound healing. PCL/PVP Nanofiber mat containing chloroform: methanol (4:1) crude bark extract of Tecomella undulata, a medicinal plant widely known for its traditional medical applications including its wound healing ability, were prepared and evaluated for their antibacterial properties. With good drug stability and high drug-loading efficacy, the incorporation of herbal extract in the polymer media did not appear to influence the morphology of the resulting fibers, as both the drug-free and the drugloaded nanofibers remained unaltered, microscopically. Activity was tested against standard strains of Pseudomonas aeruginosa MTCC 2297, Staphylococcus aureus ATCC 933, Escherichia coli (IP-406006). Extract loaded PCL/PVP nanofiber mat were able to inhibit the growth of the bacterial strains which indicate that it could act not only as a drug delivery system but also in the treatment of wound healing or dermal bacterial infections thereby proving a potential application for use as a wound dressing.

show abstract

“…Therefore, it is reasonable to assume that process 1 is much more enhanced for polymers than for model compounds [34]. A similar situation can also be expected in process 3 because there are many negatively charged species present in the cytoplasmic membrane, such as acidic phospholipids and some membrane proteins [35][36][37][38]. The disruption of the membrane (process 4) is a result of the interaction of the bound polymers with the membrane disruption and, therefore, is expected to be facilitated with increasing amounts of the bound polymers.…”

Section: Antibacterial Assessmentmentioning

confidence: 84%

CONTROLLING OF Pseudomonas cichorii AND Dickeya dadantii (Erwinia chrysanthemi) BY ELECTROSPUN NANOFIBERS OF NYLON-6/CHITOSAN BLENDS

Abdel-Megeed¹,

MW²,

Sa³

et al. 2013

Int J of Biot Appl

View full text Add to dashboard Cite

Processing of polymer nanofibers through electrospinning as drug delivery systems

Cited by 246 publications

References 35 publications

Improved shellac mediated nanoscale application drug release effect in a gastric-site drug delivery system

Improved shellac mediated nanoscale application drug release effect in a gastric-site drug delivery system

Herbal drug incorporated antibacterial nanofibrous mat fabricated by electrospinning: An excellent matrix for wound dressings

CONTROLLING OF Pseudomonas cichorii AND Dickeya dadantii (Erwinia chrysanthemi) BY ELECTROSPUN NANOFIBERS OF NYLON-6/CHITOSAN BLENDS

Contact Info

Product

Resources

About