Processing optimization, mechanical properties, corrosion behavior and cytocompatibility of additively manufactured Zn-0.7Li biodegradable metals

Yang, Hongtao; Liu, Aobo; Dai, Jiabao; Wen, Peng; Zheng, Yufeng; Tian, Yun; Li, Shuang; Wang, Xiaogang

doi:10.1016/j.actbio.2022.01.049

Cited by 46 publications

(24 citation statements)

References 50 publications

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“…Porous scaffolds produced by additive manufacturing provide freedom to modulate mechanical and degradable performance of biodegradable metal implants [ 38 ]. The customized porous structure fabricated by laser powder bed fusion (L-PBF) endows Zn alloy porous scaffolds with adjustable strength and rigidity to match bone as well as accelerated degradation owing to the enlarged surface area and improved permeability [ 39 ]. The interconnected pores provide spaces for the in-growth of new bone and blood vessels and enhance the transport of nutrients and metabolic waste [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

A drug-loaded composite coating to improve osteogenic and antibacterial properties of Zn–1Mg porous scaffolds as biodegradable bone implants

Zhang

Liu

Fan

et al. 2023

Bioactive Materials

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Section: Introductionmentioning

confidence: 99%

A drug-loaded composite coating to improve osteogenic and antibacterial properties of Zn–1Mg porous scaffolds as biodegradable bone implants

Zhang

Liu

Fan

et al. 2023

Bioactive Materials

Self Cite

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“…Biodegradable metallics are promising biomaterials due to their combination of a temporarily high mechanical load-bearing capacity and gradual degradation [9,10]. Three metals, namely, Mg [11,12], Fe [13], and Zn [14], have been developed as biodegradable implants [15].…”

Section: Introductionmentioning

confidence: 99%

3D-Printed Double-Helical Biodegradable Iron Suture Anchor: A Rabbit Rotator Cuff Tear Model

Liu

Chang

et al. 2022

Materials

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Suture anchors are extensively used in rotator cuff tear surgery. With the advancement of three-dimensional printing technology, biodegradable metal has been developed for orthopedic applications. This study adopted three-dimensional-printed biodegradable Fe suture anchors with double-helical threads and commercialized non-vented screw-type Ti suture anchors with a tapered tip in the experimental and control groups, respectively. The in vitro study showed that the Fe and Ti suture anchors exhibited a similar ultimate failure load in 20-pound-per-cubic-foot polyurethane foam blocks and rabbit bone. In static immersion tests, the corrosion rate of Fe suture anchors was 0.049 ± 0.002 mm/year. The in vivo study was performed on New Zealand white rabbits and SAs were employed to reattach the ruptured supraspinatus tendon. The in vivo ultimate failure load of the Fe suture anchors was superior to that of the Ti suture anchors at 6 weeks. Micro-computed tomography showed that the bone volume fraction and bone surface density in the Fe suture anchors group 2 and 6 weeks after surgery were superior, and the histology confirmed that the increased bone volume around the anchor was attributable to mineralized osteocytes. The three-dimensional-printed Fe suture anchors outperformed the currently used Ti suture anchors.

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“…It is interesting that a polylactide (PLA) coating on iron did not protect Fe from its corrosion, but accelerated Fe corrosion owing to the interference of Ca-P precipitating on Fe and the local acidic microenvironment on the Fe surface along with hydrolysis of the aliphatic polyester, as revealed by Ding’s group [ 47 ]. More strategies to regulate corrosion of biometals have been suggested [ 48 , 49 ], and still in progress. For example, Yuan et al .…”

Section: The Different Sources Of Biomaterials For Tissue Regenerationmentioning

confidence: 99%

Recent advances in regenerative biomaterials

Cao

Ding

2022

Regenerative Biomaterials

115

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Nowadays, biomaterials have evolved from the inert supports or functional substitutes, to the bioactive materials able to trigger or promote the regenerative potential of tissues. The interdisciplinary progress has broadened the definition of “biomaterials”, and a typical new insight is the concept of tissue induction biomaterials. The term “regenerative biomaterials” and thus the contents of the present paper are relevant to yet beyond tissue induction biomaterials. This review summarizes the recent progress of medical materials including metals, ceramics, hydrogels, other polymers, and bio-derived materials. As the application aspects are concerned, this paper introduces regenerative biomaterials for bone and cartilage regeneration, cardiovascular repair, three dimensional bioprinting, wound healing, and medical cosmetology. Cell-biomaterial interactions are highlighted. Since the global pandemic of COVID-19, the review particularly mentions biomaterials for public health emergency. In the last section, perspectives are suggested: (1) Creation of new materials is the source of innovation; (2) Modification of existing materials is an effective strategy for performance improvement; (3) Biomaterial degradation and tissue regeneration are required to be harmonious with each other; (4) Host responses can significantly influence the clinical outcomes; (5) The long-term outcomes should be paid more attention to; (6) The non-invasive approaches for monitoring in vivo dynamic evolution are required to be developed; (7) Public health emergencies call for more research & development of biomaterials; (8) Clinical translation needs to be pushed forward in a full-chain way. In the future, more new insights are expected to be shed into the brilliant field — regenerative biomaterials.

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Processing optimization, mechanical properties, corrosion behavior and cytocompatibility of additively manufactured Zn-0.7Li biodegradable metals

Cited by 46 publications

References 50 publications

A drug-loaded composite coating to improve osteogenic and antibacterial properties of Zn–1Mg porous scaffolds as biodegradable bone implants

A drug-loaded composite coating to improve osteogenic and antibacterial properties of Zn–1Mg porous scaffolds as biodegradable bone implants

3D-Printed Double-Helical Biodegradable Iron Suture Anchor: A Rabbit Rotator Cuff Tear Model

Recent advances in regenerative biomaterials

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