Procoagulant stimulus processing by the intrinsic pathway of blood plasma coagulation

Zhuo, Rui; Miller, Rachel E.; Bussard, Karen M.; Siedlecki, Christopher A.; Vogler, Erwin A.

doi:10.1016/j.biomaterials.2004.08.008

Cited by 46 publications

(94 citation statements)

References 30 publications

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“…However, the causal relation between the functional groups of chitosan and blood clotting remains unknown. It has reported that the activation of blood factor XII that potentiates the intrinsic pathway of blood plasma coagulation occurs efficiently in contact with hydrophilic procoagulants [35][36][37], due to specific binding event between factor XII. In the normal contact activation of the clotting cascade, factor XII termed Hageman factor is activated on contact with negatively charged surfaces [38].…”

Section: Resultsmentioning

confidence: 99%

Effects of low-temperature surface-wave plasma treatment with various gases on surface modification of chitosan

Oginö

Král

Yamashita

et al. 2008

Applied Surface Science

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Section: Resultsmentioning

confidence: 99%

Effects of low-temperature surface-wave plasma treatment with various gases on surface modification of chitosan

Oginö

Král

Yamashita

et al. 2008

Applied Surface Science

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“…By contrast, no such interphase concentration effect occurs at hydrophilic materials (water contact angle less than 60° according to above) because protein does not adsorb at concentrations greater than solution concentration (P = 1, see citations above). Perhaps these events partially account for the sluggish coagulation of plasma in contact with hydrophobic materials compared to hydrophilic analogs [83,84], even though FXII activation in neat solutions is found to be nearly surface-energy independent [85]. Clearly the significance of such interpretation warrants considerable investigation and verification before it is incorporated into general biomaterials thinking.…”

Section: Implications For the Biological Response To Materialsmentioning

confidence: 99%

Volumetric interpretation of protein adsorption: Kinetic consequences of a slowly-concentrating interphase

Barnthip¹,

Noh²,

Leibner³

et al. 2008

Biomaterials

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Time-dependent energetics of blood-protein adsorption are interpreted in terms of a slowlyconcentrating three-dimensional interphase volume initially formed by rapid diffusion of protein molecules into an interfacial region spontaneously formed by bringing a protein solution into contact with a physical surface. This modification of standard adsorption theory is motivated by the experimental observation that interfacial tensions of protein-containing solutions decrease slowly over the first hour to a steady-state value while, over this same period, the total adsorbed-protein mass is constant (for lysozyme, 15 kDa; albumin, 66 kDa; prothrombin, 72 kDa; IgG, 160 kDa; fibrinogen, 341 kDa studied in this work). These seemingly divergent observations are rationalized by the fact that interfacial energetics (tensions) are explicit functions of solute chemical potential (concentration), not adsorbed mass. Hence, rates-of-interfacial-tension-change parallel a slow interphase concentration effect whereas solution depletion detects a constant interphase composition within the time frame of experiment. A straightforward mathematical model approximating the perceived physical situation leads to an analytic formulation that is used to compute time-varying interphase volume and protein concentration from experimentally-measured interfacial tensions. Derivation from the fundamental thermodynamic adsorption equation verifies that protein adsorption from dilute solution is controlled by a partition coefficient at equilibrium, as is observed experimentally at steady state. Implications of the alternative interpretation of adsorption kinetics on biomaterials and biocompatibility are discussed. KeywordsProtein adsorption; kinetics; interfacial energetics; interphase; surface; radiometry IntroductionProtein-adsorption kinetics are of practical importance in biomaterials because adsorption rates have been implicated as a cause of selective protein adsorption. For example, the so-called Vroman Effect is commonly thought to occur because low-molecular-weight proteins *Author to whom correspondence should be addressed EAV3@PSU.EDU. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access Author ManuscriptBiomaterials. Author manuscript; available in PMC 2009 July 1. Published in final edited form as:Biomaterials. presumably arriving first at a surface immersed in a multi-component solution are displaced by higher-molecular-weight proteins arriving later (see refs. and citations therein). The final adsorbed-protein composition is thus purported to be achieved through a complex se...

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“…27 Classical biochemistry of the intrinsic clotting pathway suggests that a ''pro-coagulant stimulus,'' starting with exposure of plasma to a test surface, potentiates a cascade of events that culminate into the release of thrombin (Factor IIa). 29 Calcium is an activating factor that is involved in the progression of the intrinsic pathway of clot formation. The plasma recalcification profiles serve as a measure of the intrinsic coagulation system.…”

Section: Plasma Recalcification Profilesmentioning

confidence: 99%

Hemocompatibility evaluation of poly(diol citrate) in vitro for vascular tissue engineering

Motlagh

Allen

Hoshi

et al. 2007

J Biomedical Materials Res

128

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One of the ongoing challenges in tissue engineering is the synthesis of a hemocompatible vascular graft. Specifically, the material used in the construct should have antithrombogenic properties and support the growth of vascular cells. Our laboratory has designed a novel biodegradable, elastomeric copolymer, poly(1,8-octanediol citrate) (POC), with mechanical and degradation properties suitable for vascular tissue engineering. The hemocompatibility of POC in vitro and its ability to support the attachment and differentiation of human aortic endothelial cell (HAEC) was assessed. The thrombogenicity and inflammatory potential of POC were assessed relative to poly(l-lactide-co-glycolide) and expanded poly(tetrafluoroethylene), as they have been used in FDA-approved devices for blood contact. Specifically, platelet aggregation and activation, protein adsorption, plasma clotting, and hemolysis were investigated. To assess the inflammatory potential of POC, the release of IL-1beta and TNF-alpha from THP-1 cells was measured. The cell compatibility of POC was assessed by confirming HAEC differentiation and attachment under flow conditions. POC exhibited decreased platelet adhesion and clotting relative to control materials. Hemolysis was negligible and protein adsorption was comparable to reference materials. IL-1beta and TNF-alpha release from THP-1 cells was comparable among all materials tested, suggesting minimal inflammatory potential. POC supported HAEC differentiation and attachment without any premodification of the surface. The results described herein are encouraging and suggest that POC is hemocompatible and an adequate candidate biomaterial for in vivo vascular tissue engineering.

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Procoagulant stimulus processing by the intrinsic pathway of blood plasma coagulation

Cited by 46 publications

References 30 publications

Effects of low-temperature surface-wave plasma treatment with various gases on surface modification of chitosan

Effects of low-temperature surface-wave plasma treatment with various gases on surface modification of chitosan

Volumetric interpretation of protein adsorption: Kinetic consequences of a slowly-concentrating interphase

Hemocompatibility evaluation of poly(diol citrate) in vitro for vascular tissue engineering

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