Prodrugs, phospholipids and vesicular delivery - An effective triumvirate of pharmacosomes

Kapoor, Bhupinder; Gupta, Reena; Singh, Sachin Kumar; Gulati, Monica; Singh, Saranjit

doi:10.1016/j.cis.2018.01.003

Cited by 34 publications

(6 citation statements)

References 145 publications

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“…52 Increasing the activity can be achieved by vesicular delivery systems consisting of or containing prodrug/druglipid molecules known as pharmacosomes: due to the high efficiency of drug capture, prevention of leakage and explosive release. 54,55 Examples of solid lipid nanoparticles (SLNs) decorated with phosphonium conjugates are limited in the literature. 56,57 In our opinion, SLN modification by new TPP-amphiphilic conjugates is the next stage in their development.…”

Section: Resultsmentioning

confidence: 99%

Novel triphenylphosphonium amphiphilic conjugates of glycerolipid type: synthesis, cytotoxic and antibacterial activity, and targeted cancer cell delivery

et al. 2023

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Section: Resultsmentioning

confidence: 99%

Novel triphenylphosphonium amphiphilic conjugates of glycerolipid type: synthesis, cytotoxic and antibacterial activity, and targeted cancer cell delivery

et al. 2023

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“…Conventional solvent evaporation technique, Supercritical fluid process, and anhydrous cosolvent lyophilization are some of the methods for the preparation of Pharmacosomes. The bioavailability of various NSAIDs, Cardiovascular drugs, proteins, anti-neoplastic drugs, and herbal or synthetic drugs was greatly enhanced by a pharmacological lipid-based delivery system 21 . Mangiferin (MF) loaded phytosomes formulated through the phospholipid complexation method.…”

Section: Literature Review On Various Lipid-based Drug Delivery Systemsmentioning

confidence: 99%

Insights of Lipid-Based Drug Delivery Systems with an Emphasis on Quality by Design

Battula¹,

Chinthaginjala²,

Telkar³

et al. 2023

Int J Life Sci Pharm Res

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Lipid-based drug delivery systems offer several advantages and have wide solubility, permeation, and bioavailability enhancement applications. This review provides detailed information on the fabrication, application and aspects of QbD of various lipid-based vesicles. Most of the review studies focused on lipid-based vesicles without the QbD aspect. This review article covers all the lipid-based systems in escalating on the method of QbD, which enhances the bioavailability of active pharmaceutical ingredients in different formulation approaches. Among all the different available approaches towards formulation development, lipid-based drug delivery systems (LBDDS) have continually maintained the limelight on themselves. One of the reasons for the popularity of LBDDS is their ability to solve problems with poorly water-soluble drugs and their bioavailability. Several drugs' efficacy was improved by utilizing this type of delivery system. Vesosomes, Phytosomes, Solid Lipid Nanoparticles (SLNs), Nanostructured Lipid Carriers (NLCs), and Archaeosomes are novel lipid-based systems with unique applications in drug delivery. Hence, the present perspective is to review the various LBDDS approaches utilized to enhance the formulations' performance while dissecting the studies systematically to get a clear outline of various LBDD subsystems, their applications, methods of preparation, and the mechanism of drug delivery. In addition to this, the review also focuses on overcoming the lacunas of the past literature by making an attempt to identify Quality target product profile (QTPP), Critical quality attributes (CQAs) and applying them for the statistical design of experiments and continuous strategy by QbD at the same time harnessing their potential in risk assessment. Applying QbD in developing lipid-based drug delivery systems reduces the number of trials and yields a product with in-built quality as it deliberates various critical variables, process parameters, risk assessment, and control strategy in formulation development.

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“…Pharmacosomes design is based on the phospholipids/water superficial and bulk interaction; the drug molecule and the connected lipid molecule, respectively, behave like the polar head group and the lipidic chain giving the molecule an amphipathic character. Thanks to their hydrophilic and lipophilic properties, these lipid LNV improve drugs' dissolution in gastrointestinal fluid, increasing the bioavailability of low soluble treatments avoiding leak and rupture release [168,169]. Pharmacosomes' in vivo pharmacokinetic performances are conditioned by vesicles' dimension, by the drug molecule's functional groups, by the lipids' fatty acid chain length, and, last but not least, by the spacer groups' availability.…”

Section: Pharmacosomesmentioning

confidence: 99%

Lipid-Based Nanovesicular Drug Delivery Systems

et al. 2021

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In designing a new drug, considering the preferred route of administration, various requirements must be fulfilled. Active molecules pharmacokinetics should be reliable with a valuable drug profile as well as well-tolerated. Over the past 20 years, nanotechnologies have provided alternative and complementary solutions to those of an exclusively pharmaceutical chemical nature since scientists and clinicians invested in the optimization of materials and methods capable of regulating effective drug delivery at the nanometer scale. Among the many drug delivery carriers, lipid nano vesicular ones successfully support clinical candidates approaching such problems as insolubility, biodegradation, and difficulty in overcoming the skin and biological barriers such as the blood–brain one. In this review, the authors discussed the structure, the biochemical composition, and the drug delivery applications of lipid nanovesicular carriers, namely, niosomes, proniosomes, ethosomes, transferosomes, pharmacosomes, ufasomes, phytosomes, catanionic vesicles, and extracellular vesicles.

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Prodrugs, phospholipids and vesicular delivery - An effective triumvirate of pharmacosomes

Cited by 34 publications

References 145 publications

Novel triphenylphosphonium amphiphilic conjugates of glycerolipid type: synthesis, cytotoxic and antibacterial activity, and targeted cancer cell delivery

Novel triphenylphosphonium amphiphilic conjugates of glycerolipid type: synthesis, cytotoxic and antibacterial activity, and targeted cancer cell delivery

Insights of Lipid-Based Drug Delivery Systems with an Emphasis on Quality by Design

Lipid-Based Nanovesicular Drug Delivery Systems

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