Producing drugs from marine sponges

Belarbi, El Hassan; Gómez, Antonio Contreras; Chisti, Yusuf; Camacho, F. Garcı́a; Grima, E. Molina

doi:10.1016/s0734-9750(03)00100-9

Cited by 150 publications

(100 citation statements)

References 61 publications

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“…Symbiotic microorganisms of sponges and corals are archea and bacteria, actinomycetes, cyanobacteria, fungi and alage. Probable in some cases associated microorganisms have different bioactive compounds then host organisms [95]. Isolation and cultivation of the sponge symbionts and their nature of relationship have been reviewed from somewhere else [95].…”

Section: Conventional Methods For Isolation Of Therapeutic Agents Frommentioning

confidence: 99%

“…Probable in some cases associated microorganisms have different bioactive compounds then host organisms [95]. Isolation and cultivation of the sponge symbionts and their nature of relationship have been reviewed from somewhere else [95]. In general marine environment is too diverse habitat with mangroves, deep sea sediments, coral reefs and hydrothermal vents, here microbes thrive in adverse condition and can be search microbes for beneficial bioactive metabolites.…”

Section: Conventional Methods For Isolation Of Therapeutic Agents Frommentioning

confidence: 99%

See 1 more Smart Citation

Red Sea Microbial Diversity for Antimicrobial and Anticancer Agents

M¹

2016

J Mol Biomark Diagn

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Marine natural products are valuable sources that could produce potential chemotherapeutic agents, and marinederived organisms are widely recognized as important sources of these natural products with interesting biological activities. Furthermore, Red sea was recognized as a rich source of microbial diversity with unique metabolites that can be of pharmaceutical and medicinal importance. The discovery of novel active metabolites provides an intellectual challenge to examine new products for medicinal purposes. Although many bacterial strains were isolated from Red sea with potent bioactivities; however, the microbial diversity of marine environment such Red sea remained largely un-explored. Lately, it has been possible to easily collect marine samples, isolate, and further identify diverse marine organisms (e.g. bacteria, fungi, and algae and marine invertebrate) by modern molecular techniques. Based on a wide range of screening and extraction methods, a vast number of metabolites have been extracted from marine sources with potential biological activities such as antibacterial, anticancer, anti-inflammatory agents and many others. In this article, we have reviewed the previous studies that have been conducted to explore marine-derived bioactives of Red sea. In addition, we have illustrated the following aspects: (i) Red sea microbial diversity for antibacterial and anticancer agents; (ii) the conventional and molecular approach used for screening and characterization marine microorganisms; (iii) characterization of natural products of microbial origin, and (iv) drug development from novel marine-derived metabolites and clinical trials. Moreover, modern molecular technologies, meta-genomic, proteomic and bio-chemo-informatics approaches are adding more potency to the targeted search of bioactive compounds derived from marine microbes. The novel marine derived drug discovery is aimed to improve our understanding of natural resources, to improve public health awareness about the environmental microbial diversity and their importance for nutraceuticals, pharmaceutical, agrochemicals and food processing. Recently, the research area of microbial diversity of the Red sea and their metabolites has opened a new access for significant sources of more effective drug entities with low coast.extreme conditions such as high temperature, pressure, and salinity. The experimental results suggested that these bacterial and archaeal communities are rich sources of active enzymes and metabolites, which can be applied for pharmaceutical and biotechnology-based applications [9].In previous studies, a number of bio-active compounds have been reported from marine sources with different degrees of action and potential, such as antibacterial, anticancer, antitumor, antiproliferative, anti-microtubule, cytotoxic, photoprotective, and antifouling properties [10][11][12]. Marine-derived metabolites, like peptides (ribosomal and non-ribosomal), alkaloids, polyketides and terpenes, have demonstrated antimicrobial and antiviral activ...

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Section: Conventional Methods For Isolation Of Therapeutic Agents Frommentioning

confidence: 99%

Section: Conventional Methods For Isolation Of Therapeutic Agents Frommentioning

confidence: 99%

Red Sea Microbial Diversity for Antimicrobial and Anticancer Agents

M¹

2016

J Mol Biomark Diagn

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“…Marine organisms possess diverse secondary metabolite production. These secondary metabolites have different bioactive properties such as antioxidant, anti-inflammatory, cytotoxic, antimicrobial, and antitumor [1][2][3][4]. Pharmaceutical research on sponges was aroused in the year 1950's by the discovery of a number of unknown nucleosides: Spongothymidine and spongouridine in the marine sponge cryptotheca crypta [5,6].…”

Section: Introductionmentioning

confidence: 99%

Free Radical Scavenging Activity of Marine Sponges Collected From Kovalam, Chennai

Thambidurai

Dorairaj²,

Mohideen

et al. 2017

Asian J Pharm Clin Res

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Objective: The main focus of this study is to screen the marine sponges for potent free radical scavenging activity. Methods:Various methods such as 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), and ferric reducing antioxidant power (FRAP) assay are employed to ascertain the antioxidant properties of marine sponges namely Dysidea herbacea and Sigmadocia pumila.Results: On analyzing, the result of ABTS assay D. herbacea and S. pumila exhibited almost equal antioxidant properties. While calculating the inhibitory concentration 50% value for DPPH assay, the Sample 1 and 2 has an IC of 655.49 and 826.739 µl, respectively, and in FRAP assay, the Sample 1 and 2 has an IC of 67.587 and 74.57 µg, respectively. Conclusion:Overall from this assay, D. herbacea revealed slightly better antioxidant activity when compared to S. pumila, also which in future may serve as a better source to fight against various diseases.

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“…Some of the toxins which can be extracted from dinoflagellates are quite expensive, even in small amounts (Belarbi et al, 2003;Kobayashi and Tsuda, 2004). In order to utilize the toxins and other bioactive molecules produced by mass scale cultivated dinoflagellates, research on biomedical, toxicological, chemical, pharmacological and therapeutic potential is essential.…”

Section: Introductionmentioning

confidence: 99%