Sun (HEROES) hard Xray telescope flew as a balloon payload from Ft. Sumner, NM. HEROES observed the Sun, the black hole binary GRS 1915+105, and the Crab Nebula during its 27 h flight. In this paper, we describe laboratory calibration measurements of the HEROES detectors using line and continuum sources and applications of these measurements to define channel to energy (gain) corrections for observed events and to define detector response matrices. We characterize the HEROES X-ray grazing incidence optics using measurements taken in the Stray Light Facility (SLF) in Huntsville, AL, and using ray traces. We describe the application of our calibration measurements to in-flight observations of the Crab Nebula.