Production and characterization of lipid microparticles produced by spray cooling encapsulating a low molar mass hydrophilic compound

Abstract

The objective of this research was to produce and characterize lipid particles (MpLs) that may be used as carriers of high amounts of hydrophilic core and evaluate the influence of the core amount on the performance of lipid microparticles. The MpLs were produced by spray cooling from solid and liquid lipid mixtures (stearic and oleic fatty acids and partly hydrogenated vegetable fat) containing glucose solution as core and soy lecithin as surfactant. The performance of MpLs was evaluated by means of the effective amount of encapsulated core, the core amount present on the surface of MpLs (superficial glucose) and the core release profile in aqueous solution. Morphological observations showed that MpLs presented spherical shape and a rugged and continuous surface, and an average diameter between 25 and 32 µm. The effective amount of encapsulated core was greater than 78% for all formulations evaluated. Larger amounts of superficial glucose were found in formulations in which more concentrated glucose solutions were used, regardless of the glucose lipid-solution ratio. The release results showed that core retention was significantly influenced by the glucose solution concentration, whereas release modulation was influenced by the glucose lipid-solution ratio.

Use of the spray chilling method to deliver hydrophobic components: physical characterization of microparticles

“…The mean diameters varied between 13.8 and 32.2 µm, and were thus within the range reported by the literature (SAVOLAINEN et al, 2002;LEONEL et al, 2010;CHAMBI et al, 2008).…”

“…Such variation in diameters can also be observed in the size distribution shown in Figure 5. Chambi et al (2008), Leonel et al (2010) and Ribeiro, Barrera-Arellano and Grosso (2012) found similar appearance of lipid microparticles encapsulating proteins and sugars as active substances. that softer matrices tend to produce larger microparticles.…”

“…For the SEM analysis, the samples were fixed on aluminum stubs with double-sided copper adhesive tape and coated with a fine layer of gold using a sputter coater (SDC50, Bal-Tec, Balzers, Liechtenstein) for 4 coating cycles of 40 seconds each. The samples were subsequently examined using a scanning electron microscope (DSM 940A, Zeiss, Oberkocken, Germany) at an acceleration voltage of 10 kV (LEONEL et al, 2010). The same procedure described to acquire images for the mean size and In practical terms, these results indicate that matrices with low melting points tend to form lipid microparticles with larger mean diameters compared with matrices with high melting points.…”

Solid lipid microparticles of hardfats produced by spray cooling as promising crystallization modifiers in lipid systems

“…Several studies have been developed using the SC technique for the controlled release of drugs and cosmetics and the microencapsulation of proteins , hydrophilic and hydrophobic compounds , probiotics , and crystallization agents .…”

Encapsulação de colecalciferol (vitamina D₃) por <i>spray chilling</i>

“…Tanto é que na literatura constam relatos da obtenção de micropartículas com tamanho médio na faixa de 13-50 µm (SAVOLAINEN et al, 2002;CHAMBI et al, 2008;LEONEL et al, 2010;RIBEIRO;ARELLANO;GROSSO, 2012;ALVIM et al, 2013) e 50-300 µm (RODRIGUEZ et al, 1999;MASCHKE et al, 2007;ALBERTINI et al, 2008;ILIĆ et al, 2009). Os valores de tamanhos médios de partícula obtidos nesse trabalho estão na faixa do que é citado na literatura como satisfatório para micropartículas produzidas por spray chilling.…”