Production and isolation of pharmaceutical drug nanoparticles

Verma, Vivek; Ryan, Kevin M.; Padrela, Luís

doi:10.1016/j.ijpharm.2021.120708

Cited by 47 publications

(21 citation statements)

References 174 publications

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“…They are especially useful if a given molecule has poor solubility in both aqueous and non-aqueous solvents. Nanosuspensions are relatively simple to prepare and have been stated to have several advantages over other nanoformulations, such as controlled drug release, targeted drug delivery, improved bioavailability, reduced dosing frequency, reduced toxicity, and better stability [ 54 , 55 ].…”

Section: Nanometric Dispersionsmentioning

confidence: 99%

Strategies to Improve Drug Strength in Nasal Preparations for Brain Delivery of Low Aqueous Solubility Drugs

et al. 2022

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Intranasal administration is a promising route for brain drug delivery. However, it can be difficult to formulate drugs that have low water solubility into high strength intranasal solutions. Hence, the purpose of this work was to review the strategies that have been used to increase drug strength in intranasal liquid formulations. Three main groups of strategies are: the use of solubilizers (change in pH, complexation and the use cosolvents/surfactants); incorporation of the drugs into a carrier nanosystem; modifications of the molecules themselves (use of salts or hydrophilic prodrugs). The use of high amounts of cosolvents and/or surfactants and pH decrease below 4 usually lead to local adverse effects, such as nasal and upper respiratory tract irritation. Cyclodextrins and (many) different carrier nanosystems, on the other hand, could be safer for intranasal administration at reasonably high concentrations, depending on selected excipients and their dose. While added attributes such as enhanced permeation, sustained delivery, or increased direct brain transport could be achieved, a great effort of optimization will be required. On the other hand, hydrophilic prodrugs, whether co-administered with a converting enzyme or not, can be used at very high concentrations, and have resulted in a fast prodrug to parent drug conversion and led to high brain drug levels. Nevertheless, the choice of which strategy to use will always depend on the characteristics of the drug and must be a case-by-case approach.

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Section: Nanometric Dispersionsmentioning

confidence: 99%

Strategies to Improve Drug Strength in Nasal Preparations for Brain Delivery of Low Aqueous Solubility Drugs

et al. 2022

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“…In particular, introducing the nanoparticles of bioactive molecules and controlling their surface dispersion and embedment in nanoscale have been brought to the forefront in DDS design and development. Nanosizing of drug crystallites increases their surface area and consequently promotes their dissolution rate and bioavailability, both of primary importance for pharmacokinetics. , …”

Section: Introductionmentioning

confidence: 99%

“…Nanosizing of drug crystallites increases their surface area and consequently promotes their dissolution rate and bioavailability, both of primary importance for pharmacokinetics. 12,13 The use of ultrasound for formation of nanoparticles with controlled size and morphology has proved to be a simple, efficient, and eco-friendly method for compounds of varied chemical natures. 14−19 Despite the apparent advantages so far in the field of bioactive substances, only a few systems were successfully obtained via a sonochemical method: vitamin B12, 20 enzyme: amylase, 21 antibiotics: tetracycline, 22 and gentamicin.…”

Section: ■ Introductionmentioning

confidence: 99%

Sonochemical Formation of Fluorouracil Nanoparticles: Toward Controlled Drug Delivery from Polymeric Surfaces

Chytrosz-Wrobel

Gołda-Cępa

Kubisiak

et al. 2023

ACS Appl. Nano Mater.

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The biomaterial surface can be essentially upgraded with the therapeutic function by the introduction of controlled, local elution of biologically active molecules. The use of ultrasonicassisted formation of nanoparticles with controlled size and morphology can be readily utilized for such functionalization. In this study, the synthesis route for the generation of nanoparticles of fluorouracil, the bioactive molecule used in anticancer therapy, was reported. The tandem of experimental (TEM, NTA, ATR-IR) and computational (MD simulations) approaches allowed us to obtain a molecular-level picture of the cavitation bubble interface where the enrichment of fluorouracil molecules takes place. Thanks to the originally developed computational model of cavitation bubbles, we revealed that the bubble interface plays a key role in the prearrangement of drug and solvent molecules, initiating the formation of nanoparticles' seeds. The proposed mechanism can be applied to other biologically relevant molecules, suggesting that the sonochemical method can be used for the controlled formation of their nanoparticles. The results indicate a feasible way to tailor the surface of polymeric biomaterials via the embedment of nanoparticles, thus having the potential to be used for practical implications as drug delivery systems.

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“…According to a report, PLGA-nanocurcumin at 15-fold lower concentration is superior to poorly soluble native curcumin in therapeutic application [ 23 ], while another study suggested that encapsulation of nanocurcumin is 9-times more suitable than native curcumin in terms of oral bioavailability in animals [ 24 ]. Verma et al [ 25 ] concluded that liposomal nanocarriers are highly biocompatible and can entrap hydrophobic pharmaceuticals in the membrane. In other studies, hydrophobic nanocurcumin with liposomal nanocarriers are found to be highly effective in biomedical applications [ 26 , 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Dietary Curcumin Nanospheres in a Weaned Piglet Model

et al. 2021

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Curcumin is a polyphenolic compound present in turmeric with extensive uses in cooking foods and biomedical applications. However, due to its hydrophobic nature, it is poorly soluble in water and its bioavailability is very low on oral administration in organisms. In this study, we investigated the dietary curcumin nanospheres in a weaned piglet model based on the growth, serum biochemistry, proteomics, fecal coliform bacteria, and malodors in the feces of piglets. A total of 135 weaned piglets (Duroc × [Yorkshire × Landrace]) with an average initial body weight of 7.0 ± 1.0 kg (28 ± 1 days of age) were randomly distributed in 9 pens (15 pigs in each pen) fed the dietary curcumin nanospheres (CN) at 0 (control), 0.5 (T1), and 1.0 mL (T2) CN/kg of diet in triplicates for 21 days. At the end of the feeding trial, the results showed piglets fed 1.0 mL CN/kg diet had significantly higher growth performance and feed utilization than control diet (without CN). However, there were no significant differences in growth and feed utilization between piglets fed T1 and T2 diets. Serum glucose, gamma-glutamyl transferase, total bilirubin, amylase, and lipase contents were unaffected in piglets fed the experimental diets. Interestingly, piglets fed T1 and T2 diets showed significantly lower total cholesterol levels than control diet. In serum proteomics, a total of 103 differentially expressed proteins (DEPs) were identified in the piglets fed control, T1, and T2 diets, of which 14 DEPs were upregulated and 4 DEPs were downregulated. Fecal coliform bacteria and ammonia gas were significantly reduced in piglets fed T1 and T2 diets. Overall, the results indicated dietary supplementation of CN could enhance the growth, feed utilization, and immunity—and reduce fecal pathogenic bacteria as well as ammonia gas emissions—in weaned piglets.

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Production and isolation of pharmaceutical drug nanoparticles

Cited by 47 publications

References 174 publications

Strategies to Improve Drug Strength in Nasal Preparations for Brain Delivery of Low Aqueous Solubility Drugs

Strategies to Improve Drug Strength in Nasal Preparations for Brain Delivery of Low Aqueous Solubility Drugs

Sonochemical Formation of Fluorouracil Nanoparticles: Toward Controlled Drug Delivery from Polymeric Surfaces

Evaluation of Dietary Curcumin Nanospheres in a Weaned Piglet Model

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