Production and Mass Transfer Characteristics of Non-Newtonian Biopolymers for Biomedical Applications

Abstract

The market for microbial biopolymers is currently expanding to include several emerging biomedical applications. Specifically, these applications are drug delivery and wound healing. A fundamental understanding of the key fermentation parameters is necessary in order to optimize the production of these biopolymers. Considering that most microbial biopolymer systems exhibit non-Newtonian rheology, oxygen mass transfer can be an important parameter to optimize and control. In this article, we present a critical review of recent advances in rheological and mass transfer characteristics of selected biopolymers of commercial interest in biomedical applications.

Finite Element Analysis of Viscoelastic Nanofluid Flow with Energy Dissipation and Internal Heat Source/Sink Effects

“…Many of these new biopolymers exhibit beneficial rheological properties enabling enhanced performance in delivery of alginates in for example the accelerated treatment of vascular hemorrhages, arteriovenous malformations via injection in medical micro-catheters for endovascular embolization [3]. The necessity to enhance mass transfer (oxygen) in microbial biopolymers [4] has also attracted the science of nanotechnology to the optimization of such materials. As a result nano-biopolymeric fluid dynamics has emerged as an exciting new research area in medical engineering.…”

“…Recently, Khan and Gorla [37] investigated heat and mass transfer in non-Newtonian nanofluid over a non-isothermal stretching wall. Numerous applications of viscoelastic nanocomposite fabrication techniques [3,4] have led to renewed interest among researchers to investigate viscoelastic boundary layer flow over a stretching sheet. Although numerous studies of viscoelastic stretching flows have been communicated by, for example, Rajagopal et al [38,39], Dandapat and Gupta [40] and Rao [41], these do not study nanotechnological materials.…”

“…To the authors' knowledge very few studies have thus far been communicated with regard to boundary layer flow and heat transfer of a viscoelastic polymeric nanofluid (Ethylene glycol and polymer based nanofluids) extruding from a stretching sheet with energy dissipation. This problem is very relevant to modern nano-polymeric fluid manufacture processes in the biotechnology industries wherein materials can be synthesized for specific medical applications including sterile coating, anti-bacterial buffers etc [1][2][3][4] [51] also used the Jefferys model for oblique stagnation flow and heat transfer. Haq et al [52) used the Eringen microplar model to study nanofluid stagnation point flow with free convection and radiative effects.…”

Goma Xantana: características e condições operacionais de produção

“…Logo, a combinação adequada, para os níveis destes parâmetros, deve ser estudada para evitar a limitação na transferência de oxigênio ou condições de estresse hidrodinâmico (SUTHERLAND, 1993;. Em sistemas não-newtonianos, como na fermentação para produção de xantana, a agitação é mais significativa para a transferência de oxigênio do que a aeração (CASAS; SANTOS; RICHARD;MARGARITIS, 2002). Grande parte da literatura estuda diferentes condições de aeração alterando a velocidade de agitação, entre outros autores, pode-se citar Peters et al (1989); Lorda, Pastor e Balatti (1995); Casas, Santos e García-Ochoa (2000); Papagianni et al (2001).…”

The Effect of Vibration on Flow Rate of Non-Newtonian Fluid

“…The areas of applications are very broad and diverse. They include various applications in petroleum industries [3], biomedical and processing industries [8,9] as well as important applications in food engineering and processing [10].…”